Epitalon peptide review and benefits for anti-aging and bodybuilding

Epithalon peptide or Epitalon, AGAG, AE-0 peptide, AEDG, CAS 307297-39-8 is a synthetic epiphysis tetrapeptide – telomerase activator, and potential anti-aging drug developed at the St. Petersburg Institute of Bioregulation and Gerontology in the research group of Professor V. Khavinson.

The peptide was made based on the amino acid analysis of epithalamin (concentrate of the pineal gland – a neuroendocrine system bioregulator, which is the sum of peptides) and has the following sequence of amino-acids: Ala-Glu-Asp-Gly.  

The biological activity of epithalon, according to the data on human fibroblast cell cultures in vitro, is based on the induction of telomere elongation by increasing telomerase activity in human somatic cells.  1  

The elongation of telomeres by epitalon is sufficient to exceed the Hayflick limit (the limit of the number of somatic cell divisions in cell culture is 50 divisions, due to telomere shortening of the DNA molecule with each cell division).  

Epitalon for athletes and in bodybuilding  

epitalon bodybuilding

Epitalon is actively used in the world of sports as one of the bodybuilding peptides, cosmetology, and medicine for quick recovery of physical activity and energy balance lost after workouts. 

By its structure, Epitalon is a chain of 4 amino acids, which is why in the world of sports it is known as AGAG. This short peptide is known for more than 30 years already. The substance was found in the brain extracts of animals. Initially, it was tested on animals.  

The research data proved that Epitalon has a regenerating and life-prolonging effect, has a positive effect on the hormonal levels and thyroid gland.  

Epitalon helps to prevent the early aging process of cells. Later Epitalon-based analogs of this peptide (Epitalamin, Endoluten, and Pineamin) were developed. However, Epitalon takes the leading position among them. 

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The main benefits of Epitalon:

  • increased life span;  2
  • rejuvenating effect;  
  • normalization of sleep;  
  • additional strength;  
  • rapid regeneration of damaged cells;  
  • accelerated recovery after the training;  
  • prevention of dangerous diseases;  
  • improvement of the state of the skin;  
  • increased endurance.

epitalon benefits

Dosages and cycle instructions  

According to the instructions, the peptide can be administered by different methods. It is worth considering that the oral method is considered the longest and most ineffective. The intramuscular method of administration of the drug is considered preferable in the world of sports. Injections of the active ingredient under the skin guarantee a rapid entry of the drug into the bloodstream. 

The number of cycles depends on the desired result of the athlete and the individual characteristics of the body. Before injecting the peptide, it is recommended to consult a sports coach. This will help to prevent the occurrence of unwanted side effects and other troubles.  

The effectiveness of Epitalon directly depends on weight, age, the dosage of the peptide, and time of injection.  

The following cycle of the peptide is recommended for athletes:  

  • The optimally recommended dosage is 5-15mcg per 1 kg of weight per day;  
  • The duration of the cycle is 2 months, which is about 2 vials;  
  • After a two-month cycle, a break is recommended.

Before the first use of the peptide, it is recommended to carefully analyze its composition and the rules for the use and dilution of the drug. This will help to accurately dial the dosage and prevent the development of an allergic reaction.  

When used orally, the peptide is used in a dosage of 400-600mcg/day (the dosage should be divided into 2-3 doses). In the form of a spray, Epitalon is sprayed at 1-30 mg/day (the dosage is divided into 3 uses).  

Epitalon cycles can be an unlimited number of times. It is recommended that beginners take a 4-month break every 15 days. This will allow you to conclude the effectiveness of the drug and its further use. 

Important! Chills that appeared after the injection are an additional reason to consult with your sports coach.  

Since the peptide is sold in powder form, it is necessary to know how to properly dilute the dry substance. To dilute Epitalon, add 1-2 ml of distilled water to the bottle. The liquid should be poured in a thin stream. No sudden movements are allowed after filling the vial. The drug is mixed with water through smooth movements. Many people think that it is not necessary to stir the peptide because it has excellent solubility.  



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Epitalon spray  

Epitalon spray Epitalon spray is a new generation drug based on short peptide technology. It restores the proper functioning of the epiphysis (pineal gland) and regulates the production of our serotonin and melatonin.  

The epiphysis is located in the very center of the brain and plays a key role in all body systems. It produces about 40 types of bioactive compounds and affects overall physical health. It has an immune-stimulating effect.   

The result of Epitalon use will be the improvement of sleep quality, vivacity, the general strengthening of protective functions of the body, normalization of the immune system at the cellular level.

Epitalon spray is the leader among peptide sprays in the world due to its high efficiency and significance.   

Recommended for:   

  • Sleep disorders, insomnia;  
  • Fatigue, stress;  
  • Impaired immunity;  
  • Human biorhythm disturbance;  
  • Jet lag (sleep disorders after long flights);  
  • hormonal disorders.


Not recommended for children and adolescents. It is not recommended to exceed the dose without a doctor’s prescription.   

Epitalon is not hormonal so it has no toxic effect on the body. It has no side effects and does not cause complications and drug dependence. Due to its mild action, it does not cause complications to the liver and kidneys.   

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Epitalon is a unique peptide that gives a quick burst of additional energy, strength, and stamina. The action of the drug helps to achieve excellent results in sports. 

Here are Epitalon peptide testimonials below or write your own review!

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Average rating:  
 1 reviews
 by Mike
I have been using Epitalon for over 5 years now

I have been using Epitalon for over 5 years now. The usual duration of my cycle is 45 days. Sometimes I add Timalin also for better results. I noticed that I could train without any fatigue. My strength keeps on coming back. My friends say that I look at least 5 years younger than my age. After the cycle, I take a six-month break.

Actually it's a great stack of peptides Mike - Timalin + Epitalon!


  1. V. Khavinson, E. Bondarev, A. Butyugov
    – “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells” – https://pubmed.ncbi.nlm.nih.gov/12937682/
    Bull Exp Biol Med. 2003 Jun;135(6):590-2. doi: 10.1023/a:1025493705728.
  2. V K Khavinson, D M Izmaylov, L K Obukhova, V V Malinin
    – “Effect of epitalon on the lifespan increase in Drosophila melanogaster” – https://pubmed.ncbi.nlm.nih.gov/11087911/ Mech Ageing Dev. 2000 Dec 1;120(1-3):141-9. doi: 10.1016/s0047-6374(00)00217-7.

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