The Benefits of Sermorelin for Weight Loss, Bodybuilding and Anti-Aging

By the end of our review, you will know all about the benefits of Sermorelin for weight loss and anti aging, how to use it in bodybuilding, what results to expect, and all the best peptide stacks with Sermorelin.

What is Sermorelin?

Sermorelin, also known as Mod GRF 1-29, is a peptide that stimulates HGH synthesis. 1 However, the synthetic substance, similar to endogenous, has an extremely short half-life. To increase this parameter, four amines were added to the molecule. This peptide was named Mod GRF 1 29.

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This structural modification has increased the duration of action to 30 minutes, which is enough to achieve a lasting effect and stimulate the peak secretion of growth hormone. This form is also often referred to as tetra-substituted GRF (1-29) or modified, and is very often confused with CJC-1295.

If we draw an analogy with an anabolic steroid, then tetra-substituted GRF (1-29) is an analogue of testosterone propionate, and CJC-1295 – testosterone enanthate.

TIP! When buying this peptide, be sure to specify whether this form is tetra-substituted (modified) or not.

Because of the connection with plasma proteins, tetra-substituted Sermorelin is also known as CJC-1295 without DAC (Drug Affinity Complex – a special complex that extends the duration of action to several days).

To create a more convenient, long-lasting form, CJC-1295 was created. This peptide is similar in structure to the considered tetra-substituted GRF (1-29), except that the amino acid lysine was added to the sequence, which is associated with a molecule called “Drug Affinity Complex (DAC)”. This complex allows peptides to bind to blood albumins and increases the half-life to 1-2 weeks. By analogy with testosterone, this form can be compared with testosterone cypionate.

Sermorelin peptide is one of the most popular endogenous somatotropin secretion stimulants. The product is not hormonal and does not affect the endocrine system at all. This article will tell you about the correct use of GRF peptide (1-29) in bodybuilding.

How does Sermorelin work?

Very often, the representatives of various sports disciplines use pharma. Without it, it is difficult to count on success. Anabolic steroids are still the most popular. Along with the positive effects, these drugs can produce negative effects on the body. Side effects of steroids contributed to the fact that scientists began to look for safer and more effective means to improve athletic performance.

So, today you can buy HGH, SARMs, and peptides. Among these drugs, bodybuilders are particularly interested in SARMs and bodybuilding peptides. The main topic of this article is the role of Sermorelin benefits in bodybuilding and weight loss.

The peptide stimulates the production of endogenous somatotropin and does not interfere with the endocrine system. This is common to all peptides, which distinguishes them from steroids. Although Sermorelin’s half-life is short, it does an excellent job of increasing the concentration of HGH. It should be noted that the drug belongs to the group of GHRP peptides and is one of the safest of them. The molecule has much in common with the endogenous substance GRF 1-44.

As we mentioned above, one of the main advantages of this preparation is its high safety. This is proved by the fact that in the United States, the drug is prescribed to children with problems with the production of endogenous human growth hormone. Besides, in medicine, the peptide is used by people suffering from rapid weight loss.

Sermorelin can accelerate the production of one of the isoforms of insulin-like factor – MGF (mechanical growth factor).

The peptide is also able to influence the pituitary gland and thus increase the somatotropin concentration. After that, the active component of the drug is converted directly into an insulin-like growth factor. This biochemical reaction can significantly accelerate the basic metabolism and stimulate the processes of hypertrophy in muscle tissues. Thus, athletes can recover more quickly after heavy training.

Sermorelin benefits and efficiency

Sermorelin benefits

Since the drug stimulates the production of such a powerful natural anabolic as HGH, it quickly became popular among athletes. It belongs to the GHRH group and is also the safest.

Among the main effects of Sermorelin can be noted:

  • The increase in muscle mass.
  • Fat deposits in the body are reduced and lipolysis processes are accelerated.
  • The improvement of the quality of connective tissues.
  • The strengthening of the immune system.
  • The work of the cardiovascular system will normalize.

Does Sermorelin work well for weight loss in females and males?

Sermorelin injections for weight loss help burn excess fat and increase fat utilization by stimulating triglyceride degradation and adipocyte oxidation. The best peptide combination for fat burning and shedding pounds would be HGH-176-191+Sermorelin. The recommended dosage for weight loss would be as follows:

* HGH 176-191 – three times a day at 220 micrograms.

* Sermorelin three times a day at 110 micrograms.

To get the maximum possible result, you will have to follow a dietary program that limits the amount of carbohydrates in your diet.

Sermorelin in bodybuilding

Since it is possible to gain muscle mass and accelerate fat burning processes, it is mainly used by bodybuilders. In other sports disciplines, however, Sermorelin will not be as effective as it has practically no effect on physical parameters. There are many peptide cycle stacks, and this peptide can be included in almost any cycle.

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Sermorelin cycle in bodybuilding


The single Sermorelin dosage must be calculated individually by each athlete. Specialists in sports medicine recommend administering 1-2 micrograms per kilo of body weight two or three times a day. So, every day it is necessary to administer two or three Sermorelin injections at a single dose of 100 to 200 mg.

When and how to give injections?

peptide injectionsIt is desirable to give injections on an empty stomach, at least half an hour before a meal. It is recommended to eat food that contains a minimum amount of carbohydrates and fat. The scheme of Sermorelin peptide taking in bodybuilding we have considered now applies to the solo cycle. In any cycle stack, the peptide should be used in the amount of one microgram per kilo of body weight.

For example, a woman weighing 70 kg wants to conduct a solo Sermorelin cycle. To do this, she must give 140 mg three times a day (morning, lunch, and evening). For dilution of the powder, we recommend using water for injections. The peptide is injected with an insulin syringe into the fat fold of the abdomen. The duration of the course is 60 days. After that, you need to take a break for at least 2 months.

For the solo cycle, Sermorelin, like other peptides of this group, is used very rarely. You will get better results with stacks. It is important to note that the combination of several peptides does not increase the risk of side effects.

The most popular stacks will be Sermorelin and GHRP-1 or 2. There is no point in using both of them; it is enough to choose one and inject 100 micrograms in a single dose simultaneously with Sermorelin. The duration of the cycle is in the range of 6 to 12 weeks. To get the maximum effect, you should inject peptides immediately after training, a quarter of an hour before a meal, as well as before going to bed.



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How to properly store

  • At -18 degrees Celsius, the powder form retains all of its properties for five years.
  • The powder can be stored for up to 24 months;
  • The maximum period of storage of the powder form at room temperature is six months;
  • The prepared solution should be kept at a temperature of +2 to +8 degrees for a maximum of 20 days.

Where to buy online

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It should also be noted that the price of the peptide is not very high. Any athlete can afford to buy Sermorelin at this cost.

Sermorelin cycle stacks

To increase the effectiveness of the preparation, it can be combined with other peptides. Let’s look at some examples of such cycles:

Cycle of Sermorelin and GHRP-2 or GHRP-6

The single dosage of Sermorelin is 0.1 to 0.2 mL. It should be injected three times a day. The single dose of GHRP-2 or GHRP-6 is 0.1 ml. The peptide is also injected three times a day.

Sermorelin and Ipamoreline Stacking

The human growth hormone-releasing peptides Sermorelin and Ipamorelin (GHRH or GRF) activate the pituitary gland. When compared to other hormones in their class, known as growth hormone secretagogues, these peptides are shown to be extremely well tolerated and do not cause the same stimuli of hunger or rise in cortisol as those other hormones.

These are helpful in the treatment of osteoporosis, obesity, and many chronic inflammatory disorders, in addition to age-related problems. Sermorelin and Ipamorelin have a lot of advantages:

more vitality * increased sex drive * increased lean muscle mass * decreased body fat * improved sleep * increased bone mineral content * quicker recovery from exercise and accidents * increased mental clarity * increased collagen synthesis and skin elasticity

Sermorelin is injected three times a day, and its dose is 100-200 mcg.

The frequency of injections of Ipamorelin is similar, and the single dose is 0.1 milligrames.

What other peptide stacks are common in bodybuilding?

peptide stacks in bodybuilding

Let’s look at the most popular and best peptide stacks for different purposes:

TB-500 cycle

This peptide allows you to improve the function of the joint and ligament system as well as strengthen the connective tissue. TB-500 peptide may also be very useful during the treatment of trauma, as it significantly accelerates the recovery process. Another advantage of the drug is its ability to increase endurance. This made the drug popular among those who are into cyclic sports.

It should be noted that TB-500 was studied a long time ago. The main problem was choosing the most effective dosages.

CJC-1295 and GHRP-2 or GHRP-6 Stacking

This cycle is one of the most popular among bodybuilders. With its help, you can gain about 10 kg of muscle mass. These are the maximum results, which cannot always be achieved. However, about six or seven kilograms are guaranteed to you. The only disadvantage of this combination is the large number of injections since each peptide must be placed three times a day.

Cycle of CJC DAC and Peg MGF

This cycle attracts athletes by allowing them to simultaneously increase muscle mass and get rid of fat. Besides, the drugs work even if you miss the workout. Of course, the possibility of not working out and gaining muscle mass is out of the question. If after the previous cycle it is possible to have a small loss of muscles, this stack guarantees it won’t happen.

GHRP-2 and the CJC DAC cycle

The most budget-friendly option for the use of peptides. It will bring you good results. This stack of peptides can be recommended to athletes who want to get acquainted with how the peptides work.

Peg MGF and GHRP-6 cycle

Another combination of peptides, which is very popular with athletes during the muscle-gain period, On average, athletes gain about six kilograms per cycle with no after-cycle loss. The recommended cycle duration is 1.5 months.

Stacking CJC DAC with Gonadorelin and Ipamorelin

This cycle is designed to increase power. Adipose tissue is actively burned during the cycle, which will allow you to improve the shape of your muscles. This combination of peptides is the most popular among weightlifters.

GHRP and the CJC-1295 stack

Another stack that is in great demand among bodybuilders. It can safely be called universal. It helps in increasing power and gaining muscle mass at the same time. In two months of using it, you can gain about eight kilos on average. It can be recommended to bodybuilders since, in power triathlon and weightlifting, weight gain can lead to a transition to a heavier weight category.

We have considered only a few popular peptide cycles, which are used in sports. To a large extent, their popularity is associated with high efficiency and safety. This is exactly what bodybuilding enthusiasts need.


  1. Richard F Walker – “Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?” –
    Clin Interv Aging. 2006 Dec; 1(4): 307–308. Published online 2006 Dec. doi: 10.2147/ciia.2006.1.4.307

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