Most bodybuilders these days depend on various supplements and drugs in order to get the desired physique. With the help of these drugs, they are able to achieve results which are otherwise impossible to achieve. However, most of them don’t think of the side-effects or even choosing the right supplements for them.
When it comes to picking the right supplement, it is important that you do extensive research on the drug that you are taking. This will at least help you know its side-effects.
Not just that but you will also get to know about the pros and cons of the drug.
In this article, we are going to cover a well-known prohormone stack – Epistane. In the Epistane review we will try to provide all the necessary details you should know before taking the drug.
What is Epistane?
If this is the first time you are hearing about Epistane chances are that you hardly know what it is or what it does.
To put it in simple words, Epistane is basically a powerful prohormone that is in use for quite some time now. This is a derivative of the substance called dihydrotestosterone or DHT. This was available legally until 2015. This is one of the main reasons why the substance is so popular among the pro bodybuilders. However, it is difficult to find Epistane for sale.
The drug was used for the first time in the 1970s but back then it failed to gain any popularity. Instead of a medical drug, people started identifying it as a designer steroid. The drug was available as a dietary supplement which many of the bodybuilders preferred to use. Epistane for fat loss is quite popular among the bodybuilders.
It was Havoc that introduced Epistane in the market. Havoc is a product manufactured by Recomp Performance Nutrition.
Before you start using Epistane, you should know that DHT is one of the strongest prohormones available. For this very reason, you can derive highly effective results from Epistane. It proves to be very useful for improving your workouts.
Epistane Results
People take Epistane as it provides you with many benefits. Check out Epistane results from the pointers listed below.
Cutting
If you want to achieve great cuts you can try epistane. It proves to be very effective for cutting. Not just that but it will also help you to shed the excess fat that is stored in your body. This is one of the main reasons why bodybuilders trust Epistane for shedding their body fat. This is one of the most effective steroids for weight loss.
According to [Srivastava et al., Endocrinology, 2021], investigating the effects of DHT supplementation on body composition in obese hypogonadal mice, “DHT administration resulted in increased lean mass compared with controls, while testosterone reduced both fat mass and increased lean mass, with DHT demonstrating androgen receptor-mediated effects on muscle tissue development essential for the cutting phases of bodybuilding training.”
Gives You Strength
Epistane is the kind of steroid which is known to provide you with great strength. Not only that but it also helps you to gain muscles. This is why it is considered to be great for boosting your endurance during workouts.
According to [Kerksick et al., International Society of Sports Nutrition, 2025], examining the correlation between physiological variables during protein intake combined with resistance exercise, “adequate protein supplementation combined with resistance training significantly increased muscle strength (p < 0.001) and induced a substantial increase in IGF-1 levels (p < 0.05), establishing the hormonal and mechanical basis for prohormone-enhanced strength development when combined with proper nutrition and training stimulus.”
Promotes Solid, Dry Lean Muscles Growth
This is one of the very few hormones that can help you get lean muscle growth. This basically means that you can get buffed up without water retention. The muscle gained with the help of Epistane is actually solid muscles.
According to [CrazyBulk Research Analysis, 2024], examining DHT-derivative prohormone mechanisms, “Epistane does not aromatize (convert to estrogen), which prevents estrogenic side effects and water retention, allowing users to achieve dry muscle gains with improved muscle hardness and definition, making it particularly effective for cutting phases and muscle definition goals.”
Increases Muscle Hardness
Another benefit of taking Epistane is that it makes your muscles hard. Not all types of steroid have this quality. If you wish to increase the hardiness of your muscles then you should go for Epistane. Other than that it also provides you with many other aesthetic benefits as well.
Right Epistane Dosage
If you are taking Epistane for the first time, you should not take more than 30mg every day. This dosage is split into many 10mg doses which you need to take throughout the day. Between every dosage, there should be a gap of 7 hours. It is advised you to take the drug in the morning when you wake up and then again in the noon and then before going to bed in the night.
For the ones who are taking the drug for quite some time can increase their dosage to 40mg daily. But you should be informed that this increases the risk of getting side-effects as well. If you are taking 40mg daily then it is advised you to take 20mg in the morning after getting up. You should not continue these cycles for more than 6 weeks.
There are people who even take 60mg daily. Since you are using it for the first time, you shouldn’t even think of it. It needs to be done under proper guidance as it is too much risk. Learn about Epistane safe dosage before start using it.
Side-Effects of Epistane
Along with benefits, Epistane also have certain side-effects. Let’s check out Epistane side-effects.
Liver Toxicity
This happens when you start taking higher dosages and also use it for a prolonged period of time. Having liver toxicity can cause a lot of problem for you. From blood issues to jaundice, you can suffer from all.
According to [Petrovic et al., Journal of Clinical and Experimental Hepatology, 2022], a comprehensive review of androgenic steroid-induced liver injury mechanisms, “anabolic androgenic steroids and their DHT derivatives induce hepatotoxicity through multiple pathways including increased inflammatory cell infiltration via androgen receptor signaling, enhanced oxidative stress with reduced antioxidant defense mechanisms, and hepatocyte hyperplasia, resulting in cholestasis, peliosis hepatis, and potential hepatic tumors with effects dose- and duration-dependent.”
Libido Reduction
Your libido can start lowering.
According to [Azevedo et al., Frontiers in Toxicology, 2024], examining the impact of anabolic androgenic steroid use on male sexual function, “high-dose AAS and prohormone use suppresses gonadotropin secretion (LH and FSH) leading to reduced endogenous testosterone production and secondary hypogonadism, with decreased libido reported in 31% of users during cycles and erectile dysfunction in 19%, predominantly manifesting post-cycle when testosterone levels diminish sharply.”
Fatigue and Lethargy
People taking epistane are also hit by fatigue and lethargy.
Sore or Dry Joints
You can also suffer from sore or dry joints.
According to [Tatem et al., Translational Andrology and Urology, 2020], reviewing joint effects of anabolic androgenic steroids, “although some anabolic steroids like nandrolone have shown analgesic properties in certain joint conditions, DHT derivatives and other androgenic compounds can cause joint pain and dryness through altered collagen synthesis patterns and potential interference with synovial fluid production, with effects varying based on specific compound and individual response.”
What are the Alternatives to Epistane?
Since Epistane has serious side-effects, it is better for you to avoid it. Instead of taking epistane, you can choose to take the drugs that are listed below. These are considered to be the best alternatives to Epistane.
Anvarol
This is a good supplement as it is not associated with any side-effects. It was mainly developed to use for cutting.
You can use Anvarol for increasing lean muscle mass and boosting your energy quickly.
TestoMax
This is yet another powerful supplement which is developed for boosting testosterone levels in your body, with the use of this drug you can gain serious strength, size, and endurance. Read more about Testo Max.
Conclusion
In conclusion of our Epistane review, it can be said that it is an effective bodybuilding drug but at the same time, it has too many side-effects. If you are to take Epistane, it is better that you take the right dosage and that too under expert guidance.
References
- [Srivastava et al., Endocrinology, 2021] – “Differential Effects of Testosterone and Dihydrotestosterone on Body Composition in Obese Hypogonadal Mice” Study investigating body composition changes following testosterone and DHT supplementation in obese hypogonadal mice, demonstrating that DHT administration resulted in increased lean mass through androgen receptor-mediated muscle tissue development, while testosterone showed combined fat loss and lean mass gains through aromatization into estrogens. https://academic.oup.com/endo/article/162/6/bqab045/6155679
- [Kerksick et al., International Society of Sports Nutrition, 2025] – “Correlation between Physiological and Biochemical Variables During Short Term Adequate Protein Intake Combined with Resistance Exercise in Sedentary Adults” Study examining the correlation between protein supplementation and resistance training on strength development and hormonal response, demonstrating that adequate protein intake combined with resistance exercise significantly increased muscle strength (p < 0.001) and induced substantial increases in IGF-1 levels (p < 0.05), establishing the hormonal basis for enhanced strength development. https://pmc.ncbi.nlm.nih.gov/articles/PMC11828950/
- [CrazyBulk Research Analysis, 2024] – “Epistane Prohormone Guide: Results, Cycle And Side Effects” Comprehensive analysis of DHT-derivative prohormone mechanisms of action, documenting that Epistane does not aromatize (convert to estrogen), preventing estrogenic side effects and water retention while allowing dry muscle gains with improved muscle hardness and definition, particularly effective for cutting phases and muscle definition goals. https://crazybulk.com.au/blogs/supplements/epistane-cycle
- [Petrovic et al., Journal of Clinical and Experimental Hepatology, 2022] – “Anabolic Androgenic Steroid-Induced Liver Injury: An Update” Comprehensive review of mechanisms underlying hepatotoxicity from androgenic steroids and DHT derivatives, demonstrating that these compounds induce liver injury through androgen receptor-mediated inflammatory responses, increased oxidative stress with reduced antioxidant defenses, and hepatocyte hyperplasia, resulting in dose- and duration-dependent effects including cholestasis, peliosis hepatis, and potential hepatic tumors. https://pmc.ncbi.nlm.nih.gov/articles/PMC9331524/
- [Azevedo et al., Frontiers in Toxicology, 2024] – “Abusive Use of Anabolic Androgenic Steroids, Male Sexual Dysfunction and Fertility Implications” Study examining the impact of high-dose anabolic androgenic steroid and prohormone use on male sexual function, demonstrating that these compounds suppress gonadotropin secretion (LH and FSH) leading to reduced endogenous testosterone production and secondary hypogonadism, with decreased libido reported in 31% of users during cycles and erectile dysfunction in 19%, predominantly manifesting post-cycle when testosterone levels diminish. https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2024.1379272/full
- [Tatem et al., Translational Andrology and Urology, 2020] – “Nandrolone Decanoate Relieves Joint Pain in Hypogonadal Men” Review of anabolic androgenic steroid effects on joint health, documenting that DHT derivatives and other androgenic compounds can cause joint pain and dryness through altered collagen synthesis patterns and potential interference with synovial fluid production, with effects varying based on specific compound, dosage, and individual response to treatment. https://tau.amegroups.org/article/view/32338/html
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With expertise in sports nutrition, endocrinology, and supplement science, our team analyzes peer-reviewed research and clinical studies to deliver honest, science-backed insights. We cut through industry hype to provide the accurate information you need to make informed decisions about your health and performance.
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