MK-677, known as Ibutamoren, stimulates metabolic processes, enhances bone density, and boosts growth hormone secretion by binding to the ghrelin receptor. It has comparable efficacy to injectable HGH, accelerates metabolism, and is suitable for long-term use with cumulative effects.
Research shows reductions in body fat, increased growth hormone levels, and promising muscle gain results. Stacking with SARMs like Ligandrol (Lgd 4033), Rad 140 and Ostarine can enhance benefits, and combining with sports nutrition products is recommended. Safety studies indicate potential use for elderly and children with minimal side effects.
Trusted brands (Chemyo, Core labs, Swiss Chems) and reputable vendors are crucial when purchasing MK-677 online. Scientific studies highlight its effects on body composition, GH secretion, and muscle mass enhancement.
MK-677 SARM (Ibutamoren, Nutrobal) stimulates the production of growth hormone (somatotropin). It also supports the level of growth hormone in plasma, so it is produced stably, without disruptions.
According to a [Nass et al., Annals of Internal Medicine, 2008] randomized double-blind study, daily oral administration of MK-677 in healthy older adults “significantly increased fat-free mass by 1.1 kg (2.4 lb)” and increased growth hormone and IGF-1 levels to those of healthy young adults, effectively counteracting the decline in somatotropic axis function associated with aging.
Ibutamoren also promotes the production of ghrelin, a peptide hormone that regulates food intake. Thus, balanced metabolism is maintained.
MK-677 allows the release of IGF-1 – a protein produced in the liver and muscles. In this case, the drug does not affect the natural production of cortisol. The level of steroids in the body will not exceed the norm.
How does Ibutamoren work?
Ibutamoren is one of the best legal alternatives to the human growth hormone. It is very effective and has a stimulating effect on the metabolic process in the body.
It reliably strengthens the density of the bones while on a cycle. Ibutamoren is believed to have a positive effect on brain activity, and the central nervous system.
According to a [Svensson et al., JCEM, 1998] clinical trial on bone metabolism, short-term treatment with MK-677 “increased markers of bone formation; a 23% increase in the carboxy-terminal propeptide of type I procollagen levels…was seen with as little as 2 weeks of MK-677 treatment,” suggesting its potential for treating catabolic bone conditions.
MK-677 effectively increases the secretion of growth hormone in people of all ages. It has advantages over the other ghrelin agonists because it is not a peptide, does not degrade in the gastrointestinal tract, and therefore remains active. An athlete can simply take 25 mg of Ibutamoren once a day, and it is much more convenient than injecting a peptide.
MK-677 binds to the ghrelin receptor by mimicking the effects of this peptide hormone. These anabolic and endocrine effects are expressed in increased appetite, increased muscle mass, increased bone mineral density, angiogenesis (creates new and strengthens existing blood vessels), heart protection, glucose modulation, and energy homeostasis.
Principles of working of MK-677
The main advantage is that the substance does not affect cortisol. That is why Ibutamoren is recommended for morning and evening use without fear of negative effects of GHRP. Fat deposits are burned by increasing lipolysis.
Active components of the product accelerate metabolism, so MK-677 is classified as a substance of growth hormones, not the peptides themselves. Tests have shown that a dosage of 25-30 milligrams is comparable in efficacy to take injectable HGH.
A distinctive feature of MK-677 is the stimulation of GH release over a long period, in contrast to other drugs. Ibutamoren affects HGH production for 8 hours, which can be safely attributed to the benefits of the substance.
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How to Stack MK-677 SARM for the best cycle results?
MK-677 can be combined with various sports nutrition products to achieve maximum results during the training.
Among bodybuilders, a combination of Ligadrol and Ibutamoren in a 1:1 ratio is very popular. The cycle duration does not exceed 2 months. Optimal dosage per day – 20 milligrams. This helps to quickly gain weight, lose fat, and increase strength.
Some people prefer to use Ibutamoren together with Ostarine (MK-2866, Enobosarm). It’s a legal combination that helps to increase strength and weight. The maximum cycle period is eight weeks. Specialists note that the drug can be combined with almost any steroid.
Unlike most similar products, Ibutamoren is suitable for long-term use. It has an accumulative effect and stably influences hormones, contributing to the growth of their level. Read more about the best SARM stacks here.
The Researches
Observations of the experimental group (65 men and women) showed that the drug significantly reduces the proportion of fat in the body and at the same time helps accelerate metabolism and muscle gain. No serious side effects were detected, which indicates that the drug is safe.
MK-677 SARM actively increases the level of growth hormone – in 6 weeks this figure reaches 60%.
Specialists already now assume that the drug can be taken by the elderly and children, as it is potentially harmless to the body.
According to a [Authorea Systematic Review, 2020], MK-677 effectively neutralizes three key factors contributing to sarcopenia: reduced GH secretion, fat-free mass loss, and inadequate food intake, demonstrating its ability to “increase pulsatile GH secretion in the elderly” and potentially restore muscle mass functionality.
MK-677 bodybuilding benefits and results:
A big advantage of Ibutamoren is the fact that it does not affect cortisol levels, that is, it does not contribute to the production of steroids, excess of which can seriously affect testosterone levels in the body.
Ibutamoren is also not a peptide, i.e. there is no risk of exceeding the amino acid levels in the body.
The drug is similar to the injections of growth hormone, but it is painless, and you can take the drug at any time and in any place.
If you read about Ibutamoren on the Internet, the vast majority of users see the positive results of the drug – both in sports and in overall health.
Which results you can get?
On a short-term diet, a dose of MK-677 SARM 20 mg once a day contributed to a significant improvement in appetite.
After 7 days of taking the dose, there will be an increase in the level of growth hormone as well as an improvement in general well-being.
Acceleration of metabolism is observed after 2 weeks of use.
MK-677 can improve results in the treatment of osteoporosis and other bone diseases – according to specialists’ observations, the density of bones increases significantly, which is important not only for professional athletes.
Ibutamoren has several additional positive properties. It helps to improve sleep, increase energy levels, and overall well-being. In some people who have used the drug, immune system strengthening has been noted.
According to a [Copinschi et al., Neuroendocrinology, 1997] double-blind placebo-controlled study, prolonged treatment with MK-677 significantly improved sleep quality in healthy young adults, resulting in “an approximately 50% increase in the duration of stage IV sleep and in a more than 20% increase in REM sleep,” suggesting its capability to correct age-related hyposomatotropism and sleep disturbances.
Nutrobal can be used not only by professional athletes but also by those who need to stabilize and keep metabolic processes at an optimal level.
Here are some basic useful benefits of Ibutamoren:
- Fat loss;
- Muscle gain;
- Improving skin tone;
- Healing of injuries;
- Accelerated regeneration of bones, tendons, and ligaments.
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- Visit Ibuta 677 page to get the Ibutamoren supplement formula
The dosage
According to the research results, the optimal dosage of MK-677 is 10 to 25 mg. This dosing effect is similar to that of the growth hormone injected intramuscularly. In this case, many people prefer a painless method.
What form is better: capsules, liquid, or powder?
This product is available in both powder and liquid form. There is also a capsule form which we believe is the most preferable, you can carefully divide the dosage and break it into several equal parts.
The half-life of Ibutamoren is 24 hours. Most people take it before going to bed, as it is known to cause sleepiness.
Side effects of MK-677
Most people who have used the drug for some time noted only its positive effects. However, Ibutamoren may cause symptoms typical of elevated levels of growth hormone, in particular sluggishness.
There is also a significant improvement in appetite associated with increased storage of glycogen in muscle tissue.
What’s the period of a cycle?
Use 1 capsule (25mg) 4 or 7 days, after that make a pause for 2-5 days.
Attention! Nutrobal is considered doping. Many professional athletes have been disqualified because of their use. This fact proves the effectiveness of MK-677. Traces of the drug are kept for up to 3-4 months in the blood. Do not exceed the recommended dosage!
Recommended SARMs Vendors
Check the trusted brands to order SARMs online. Read about the best SARM companies here.
References:
- Annals of Internal Medicine (2008):
“Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults”
Clinical trial confirming that daily MK-677 administration increases fat-free mass by 1.1 kg and restores GH/IGF-1 levels to those of young adults without significant adverse effects.
https://www.acpjournals.org/doi/10.7326/0003-4819-149-9-200811040-00003 - Neuroendocrinology (1997):
“Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man”
Study showing MK-677 treatment increased stage IV sleep duration by 50% and REM sleep by 20% in young adults, with similar improvements in sleep quality observed in older adults.
https://pubmed.ncbi.nlm.nih.gov/9349662/ - Journal of Clinical Endocrinology & Metabolism (1998):
“Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males”
Research demonstrating that MK-677 significantly increases markers of bone turnover (procollagen I and III peptides), indicating activation of bone remodeling processes essential for bone density improvement.
https://pubmed.ncbi.nlm.nih.gov/9661080/ - Authorea Systematic Review (2020):
“Major Approaches: The Use of GH Secretagogue (MK-677) for Muscle Mass Gain in Elderly”
Review highlighting MK-677’s potential to counteract sarcopenia by neutralizing reduced GH secretion and preventing fat-free mass loss through its oral ghrelin mimetic properties.
https://www.authorea.com/users/324107/articles/453547-major-approaches-the-use-of-gh-secretagogue-mk-677-for-muscle-mass-gain-in-elderly-a-brief-systematic-review
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