TB-500 PEPTIDE REVIEW $23.96 – $405.56
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Overall Rating:(4.5)
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Quality:(4.6)
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Summary
TB-500 is a synthetic peptide that mimics thymosin beta-4, a natural healing protein found in the human body. This peptide helps your body repair damaged tissues faster by activating cell migration, reducing inflammation, and promoting new blood vessel formation.
TB-500 works systemically (throughout the entire body) rather than in just one area, making it useful for various injuries and recovery needs. It was originally discovered in thymus glands and platelets, where it plays a key role in wound healing.
TB-500 is particularly popular among athletes and people recovering from injuries because it can significantly speed up healing times for muscle tears, tendon damage, ligament sprains, and joint problems.
📦 Product: TB-500 (Thymosin Beta-4) Healing Peptide
Available as lyophilized (freeze-dried) powder in 5mg, 10mg, and 25mg vials that require reconstitution with sterile water before injection. Also available as pre-mixed nasal spray formulations and in combination blends with BPC-157.
Pharmaceutical-grade purity verified at ≥99% through HPLC (High-Performance Liquid Chromatography) testing. White or off-white powder appearance. Molecular weight: 4,963 g/mol.
🔬 Lab Verified (3rd Party)
All products are independently tested for purity (≥99% HPLC), molecular identity (mass spectrometry), and sterility. Suppliers provide detailed Certificates of Analysis (CoA) with batch numbers, test dates, and purity percentages.
Manufactured in GMP-certified facilities with ISO-compliant cleanrooms. Cold-chain packaging with ice packs protects products during shipping. No harmful contaminants or heavy metals detected.
⚙️ How It Works
TB-500 binds to actin proteins in cells, which are responsible for cell movement and structure. This allows healing cells to migrate quickly to injured areas. The peptide also stimulates the formation of new blood vessels, which delivers oxygen and nutrients to damaged tissue. It reduces inflammation by lowering inflammatory proteins called cytokines.
Additionally, TB-500 promotes collagen production, which is essential for strong tissue repair. All of these actions work together to dramatically speed up the body’s natural healing process.
💉 Dosage & Administration
Standard Loading Protocol: 1–2.5mg injected subcutaneously daily for 20 days near or around the injury site if possible.
Maintenance Phase: 1mg injected 1–2 times per week for ongoing support.
Total Cycle: Usually 4–8 weeks maximum.
Administration: Subcutaneous injection (under the skin) is most common, though intramuscular injection is also possible.
Reconstitution:Mix powder with sterile or bacteriostatic water only. Never shake vigorously; gently swirl to mix.
🎯 Main Benefits
Accelerated healing from muscle tears and tendon injuries, reduced pain and inflammation within 1–2 weeks, improved joint flexibility and mobility, faster recovery after surgery, reduced scar tissue formation, improved blood flow to injured areas, enhanced tissue quality and strength, and ability to heal injuries that are difficult to treat with other methods.
💲 Pricing
Single 5mg vial: $38–$45 USD, Single 10mg vial: $78–$140 USD, 10-vial kits (50mg or 100mg total): $160–$300 USD, Nasal spray (pre-mixed): $89–$150 USD, European suppliers: €69–€95 (approximately $75–$104 USD), Bulk discounts: 5–10% off when ordering 5+ units.
🚚 Shipping & Delivery
Free shipping on USA orders over $200. International shipping: 5–10 business days. European orders over €100 qualify for free shipping. Cold-chain packaging with ice packs included. Discreet, professional packaging standard. Tracking numbers provided with all orders. Expedited options available from premium suppliers.
💳 Payment Methods
Credit cards (Visa, MasterCard, American Express), PayPal, wire transfer, cryptocurrency (Bitcoin often offers 5–10% discounts).
🧊 Storage & Reconstitution
Lyophilized powder is stable at room temperature but lasts longest in a freezer at -18°C (24 months). After mixing with sterile water, keep refrigerated at 2–8°C and use within 14–30 days. Never freeze reconstituted solution or shake it vigorously. Protect from direct sunlight and extreme temperatures.
⚖️ Legal Status
TB-500 is not FDA-approved for human use in the United States. It is sold exclusively for research and laboratory purposes. Not approved as a dietary supplement or food product. Banned by WADA (World Anti-Doping Agency) for competitive sports. Supplier labels state “for research use only” and “not for human consumption.”
🔴 Common Side Effects
Most users tolerate TB-500 well with minimal side effects. Mild injection site reactions (redness, slight swelling, itching) occur occasionally. Some users report temporary headaches, dizziness, or fatigue in the first 1–3 days. Nausea is rare but possible. One uncommon concern is potential skin darkening (hyperpigmentation) due to melanocortin receptor activation, though this is very rare and usually temporary.
⚠️ Important Information
TB-500 works best when combined with proper rest, physical therapy, or rehabilitation. Results typically appear within 1–4 weeks depending on injury severity. Some users stack TB-500 with BPC-157 for enhanced healing effects. Individual response varies based on injury type and severity. Consult a healthcare provider before use, especially if you have cardiovascular issues or are on medications.
Pros
✅ Fast and Dramatic Injury Healing – Users report significant improvement in muscle tears, tendon injuries, and joint damage within 1–4 weeks.
One Reddit user with a severe finger pulley tear noticed major improvement within days and could return to climbing activities in about 6 weeks (normally takes 6+ months).
Another user with an elbow injury reported 90% pain reduction within a week.
✅ Improved Recovery Speed During Workouts – Users report workout recovery is 1.5x faster than normal. Muscle soreness decreases quickly, allowing more frequent and intense training. Athletes can train harder without excessive recovery time needed between sessions.
✅ Helps Injuries That Won’t Heal Normally – Works great for stubborn injuries that don’t respond to typical treatments.
One climber who had a previous hand injury that took over a year to heal found TB-500 reduced recovery time dramatically. Excellent for chronic injuries and long-term pain.
✅ Works Systemically Throughout the Body – Unlike treatments that only help one area, TB-500 supports healing everywhere simultaneously.
You don’t need multiple injections at different locations. The peptide travels throughout your system promoting healing.
✅ Minimal and Mild Side Effects – Most users experience no serious problems. Only mild issues like temporary fatigue, brief headaches, or slight injection site redness occur.
Side effects are usually temporary and fade quickly. Much safer than many other healing treatments.
✅ Excellent Supplier Quality and Fast Shipping – Top suppliers like Verified Peptides and Trident Peptides consistently receive 4.8–5.0 star ratings.
Products arrive within 3–7 business days. Packages are well-protected and professionally packaged. Customers praise fast and reliable delivery.
✅ Third-Party Testing and Transparency – Reputable suppliers provide lab test certificates proving 99%+ purity. Independent testing confirms products are genuine and properly dosed. Customers receive documentation showing product quality and authenticity.
Cons
❌ Unexpected Swelling and Fluid Buildup – Some users experience increased swelling at the injury site after 1–2 weeks of use.
One climber’s finger became persistently swollen, making normal movement difficult. This temporary swelling indicates healing but can limit activity during recovery.
❌ New Pain After Initial Improvement – A few users report that after initial pain relief, new types of pain develop that weren’t there before.
One Reddit user noted lingering pain they didn’t have previously. This makes it unclear whether TB-500 truly healed the problem or just masked pain temporarily.
❌ Variable Results Depending on Injury Type – TB-500 works great for some injuries but is less effective for others.
Structural spine problems and disc herniation show limited improvement. Results depend heavily on the specific type of injury and individual response.
❌ Limited Human Research and Safety Data – Most evidence comes from animal studies and user reports, not clinical trials with humans.
Long-term effects are not fully known. Unknown risks exist from using an investigational compound without comprehensive human testing.
❌ High Cost with Temporary Effects – Single 5mg vials cost $38–$45. Typical protocols need 2–4 vials ($76–$180+). Results fade when you stop using it; healing doesn’t permanently solve chronic problems. Repeat cycles may be needed for ongoing management, making it expensive long-term.
❌ Inconsistent Product Quality from Some Suppliers – One Trustpilot review reported ordering from Trident Peptides and receiving no delivery or communication.
Some budget suppliers may provide weak or fake products. Quality varies significantly between suppliers, requiring careful vendor selection.
❌ Not Many Real Reviews on Major Platforms – Hard to find honest customer feedback on Amazon, Google, or mainstream review sites.
Most reviews appear on specialty peptide forums and supplier websites. Difficult for average people to verify if the product really works.
❌ Requires Subcutaneous Injection – Must be injected under the skin rather than taken orally. Some people find injections painful or uncomfortable. Requires learning proper injection technique and sterile handling.
User Review
( votes)What is TB500?
Thymosine Beta 4 or TB-500 peptide is a synthetic analog of the peptide found in almost all human cells and includes 44 amino acids. Its main and most powerful function is its ability to quickly heal sports injuries and micro-traumas. As well as to reduce physiological stress resulting from extremely intensive sports activities.
That is why TB 500 peptide capsules are productively used in pre-competition training in order to quickly gain and, just as importantly, maintain the athlete’s best form.
In addition to quickly improving, one’s form after an illness or injury, it also has benefits for the majority of sports parameters:
- endurance
- joint mobility,
- strength (especially speed),
- extensibility of ligaments.
Interestingly, this peptide was originally used in horse races, where it had a huge impact on the outcome of the competition.
Thymosine beta 4 benefits and effects
- Increase strength and endurance quickly and noticeably;
- Relieve muscle spasms and improve muscle tone;
- Improve metabolism, ensure the supply of nutrients to all cells;
- Speed up tissue repair, enhance immunity;
- Positively influence connective tissues, improving flexibility and mobility of joints and reducing their inflammation;
- Increase the sensitivity of body tissues to the hormone IGF-1;
- Improve blood supply to the muscles and enhance vascular growth in the muscles; increase the number of red blood cells.
According to groundbreaking research published in Nature, [Srivastava et al., Nature, 2012] examining cardiac repair with thymosin beta 4: “Thymosin β4 promotes myocardial survival in hypoxia and promotes neoangiogenesis, resulting in cardiac repair after injury. When combined with cardiac reprogramming factors, thymosin β4 and cardiac reprogramming technology may synergistically limit damage to the heart and promote cardiac regeneration through the stimulation of endogenous cells within the heart.”
In medicine, TB-500 allows a quick recovery after myocardial infarction and enhances the treatment of ischemic heart disease.
According to a clinical study published in Frontiers in Pharmacology, [Bock-Marquette et al., 2013] on cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury: “Systemic dosing of Tβ4 (intramuscular or intraperitoneal) following acute myocardial infarction resulted in significant reductions in infarct size and plasma biomarkers of cardiac injury. Repeated dosing may be required to achieve clinically measureable improvements in cardiac function post-myocardial infarction, with improvement in cardiac function possibly occurring in the absence of a high degree of angiogenesis.”
Athletes who have used TB 500 note the high healing capacity of joints, both for minor wear and major injuries. In some countries, the peptide is especially popular with track and field athletes.
Is TB-500 a steroid?
TB-500 isn’t a steroid at all. It is a synthetic analogue of the natural peptide Thymosin Beta 4. This protein is produced by the thymus gland and has healing effects based on several mechanisms, including increased actin activity, enhanced angiogenesis (blood vessel formation) and reduced inflammation.
TB 500 dosage: how to take it?
TB-500 for injection must be pre-dissolved in special water for injection—sterile or bactericidal. One vial usually takes 2 mL of water. The diluted peptide should be stored in the refrigerator at 2-8 °C. The solution made using sterile water can be stored for 6-7 days, and up to 3 weeks if bactericidal water is used.
The TB-500 cycle includes several phases:
- Phase 1: Over the cycle of a week, 5 injections of 2mg of the peptide must be given, ending up using 10mg in total. This is about 1 vial per day.
- Phase 2: This lasts for 5 weeks. We inject 5mg in 2 injections (2.5mg each) each week. That’s about two vials a week.
- 3 Support: For 5 weeks, we inject 2 mg once a week. This is one bottle a week.
Some athletes use TB-500 as a strength enhancer during competitions. It is 100% drug-free, but its use as a doping agent is quite risky since TB-500 can be detected in the blood by liquid chromatography.
The peptide has no side effects, even in doses that are many times higher than recommended. But it is worth considering that increasing the TB 500 dosage very rarely increases the effect of the peptide.
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How does TB 500 work?
According to comprehensive research published in the International Journal of Biochemistry & Cell Biology, [Huff et al., 2001] on actin-sequestering beta-thymosins: “TB-500 binds to G-actin monomers, inhibiting actin polymerization and acting as an actin-sequestering molecule. The peptide may promote cell migration by interacting with actin in the cell cytoskeleton. These characteristics are activated by increasing endothelial cell migration and keratinocytes, possibly increasing the synthesis of extracellular matrix-degrading enzymes and promoting wound healing.”
With intense workouts, the joints wear out quickly. Cartilage tissue cells do not have enough time to secrete enough extracellular proteins, of which the inter-articular layer is formed. The layer is gradually destroyed by other extracellular compounds (metalloproteases). This leads to pain and joint destruction.
Thymosin beta 4 helps cartilage cells synthesize substances that then form the intercellular substance and enlarge the cartilage from the inside out. In addition, the peptide inhibits the action of metalloproteases and promotes the movement of stem cells to the problem area. It turns out that TB 500 not only prevents the destruction of joints but also stimulates the repair of already destroyed tissue.
According to wound healing research published in The Journal of Investigative Dermatology, [Malinda et al., 1999] on accelerating wound healing with thymosin beta-4: “Topical and intraperitoneal administration of TB-500 resulted in 42% improved healing status compared to saline controls by day four. At day seven, wound healing was 61% better in the TB-500 group than in wounds treated with saline. Keratinocyte migration was monitored with the Boyden chamber assay, showing 300% more stimulation in the TB-500 group compared to saline within just five hours, at concentrations as low as 10 pg.”
TB 500’s capability to heal wounds and restore muscle tissue is also related to the peptide’s ability to deliver stem cells to the site of damage. This requires an injection to the site of the injury.
TB-500 and BPC-157 peptides stack
In terms of regeneration, healing and recovery, peptides TB-500 and BPC-157 have beneficial synergistic effects on the body. Each peptide promotes enhanced recovery from injuries of joints, bones, muscles and connective tissue.
According to clinical research published in Frontiers in Pharmacology, [Sikiric et al., 2021] on stable gastric pentadecapeptide BPC 157 and wound healing: “BPC-157 demonstrates practical applicability for skin wound therapy, including incisional/excisional wounds, deep burns, diabetic ulcers, and alkali burns. The antiulcer peptide enhances proliferation, migration, and angiogenesis in vitro and shows significant improvements in wound contraction and reepithelialization in vivo with no reported toxicity.”
At the same time each of them provide a protective effect and help prevent injuries, increase flexibility, and strengthen musculoskeletal tissue, tendons, and ligaments. Nevertheless, they have significant differences in structures, places of concentration, and strength of effect on different types of body tissues.
Many have observed that TB-500 has a predominant effect on muscle tissue as opposed to BPC-157, which includes muscle damage repair as well as growth and strength enhancement effects. There are also reports that both peptides have healing and protective effects on joint, bone and connective tissue.
The daily dosage of BPC-157 is up to 600-750 mcg, and TB-500 is 5mg to 20 mg per week. Such cycle is suitable for people with weight from 50 to 100 kg.
Research on the TB 500 peptide
The thymosin hormone, of which thymosin beta 4 peptide is a part, was first obtained in 1965 from the bovine thymus gland at the University of Texas. Experiments on animals proved the hormone’s effect on the body’s immune responses.
Later, thymosin beta 4 was isolated, which in experiments on mice showed the ability to restore the myocardium. In 2012, scientists investigated the effects of using the TB500 peptide on volunteers. Clinical trials of the effects of Timosin beta 4 on the myocardium began in 2016 and were suspended in 2019. During these trials, the peptide was shown to be effective and had no serious side effects.
Clinical trials of TB 500 in gel form for the treatment of bedsores have been successfully completed, as have trials on volunteers with trophic venous ulcers. The peptide has proven to be effective.
According to a comprehensive clinical report published in Translational Medicine Communications, [Maar et al., 2021] on utilizing developmentally essential secreted peptides such as thymosin beta-4: “The significance of TB4 regarding cardiac regeneration and repair was first indicated when external administration of TB4 promotes myocardial cell migration and survival in embryonic tissue in vitro and retains this property following birth. After coronary artery ligation in mice, the peptide enhanced myocyte survival and improved cardiac function. Remarkably, the degree of improvement when TB4 was administered systemically through intraperitoneal injections or only locally within the cardiac infarct was not statistically different, suggesting beneficial effects occur through a direct effect on cardiac cells.”
There are 14 trials of thymosin beta 4 in the clinical trials database (ClinicalTrials.gov). Officially, the World Anti-Doping Agency prohibits the use of Thymosin Beta 4 peptide because it enhances the physical capabilities of humans. There is no accurate test to determine TB 500 in the body.
According to the World Anti-Doping Agency (WADA), [WADA Prohibited Substances, 2010] thymosin beta-4 is classified as a prohibited substance under section S2 (peptide hormones, growth factors, related substances, and mimetics). The substance is prohibited because it meets multiple WADA criteria: it poses a potential health risk, it has demonstrated potential to enhance sport performance, and its use is considered to violate the spirit of sport.
TB 500 side effects
Individual intolerance studies using a placebo showed no side effects. Pregnant and lactating women, as well as those under the age of 18, should avoid this product. To avoid TB 500 side effects, follow the rules:
- adhering to the injection schedule;
- following your diet and exercise regimen;
- strict adherence to recommended dosages;
- timely cessation of intake;
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References
- Bock-Marquette, I., et al. (2013) – “Cardioprotection by Systemic Dosing of Thymosin Beta Four Following Ischemic Myocardial Injury” published in Frontiers in Pharmacology. The study demonstrated that systemic dosing of Tβ4 (intramuscular or intraperitoneal) following acute myocardial infarction resulted in significant reductions in infarct size and plasma biomarkers of cardiac injury, with repeated dosing required for clinically measureable improvements in cardiac function post-myocardial infarction. [Bock-Marquette et al., 2013]
- Huff, T., et al. (2001) – “Actin-Sequestering Beta-Thymosins: Modulators of Actin Dynamics” published in the International Journal of Biochemistry & Cell Biology. The review documented that TB-500 binds to G-actin monomers, inhibits actin polymerization as an actin-sequestering molecule, and promotes cell migration by interacting with actin in the cell cytoskeleton through increasing endothelial cell migration and keratinocyte activity. [Huff et al., 2001]
- Maar, K., et al. (2021) – “Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 in Regenerative Therapy” published in Translational Medicine Communications. The comprehensive report documents that external TB4 administration promotes myocardial cell migration and survival in embryonic tissue in vitro and after birth, with coronary artery ligation in mice showing enhanced myocyte survival and improved cardiac function. The study confirmed that systemic and local cardiac administration showed comparable beneficial effects, suggesting direct action on cardiac cells. [Maar et al., 2021]
- Malinda, K.M., et al. (1999) – “Thymosin Beta-4 Accelerates Wound Healing” published in The Journal of Investigative Dermatology. The study showed that topical and intraperitoneal administration of TB-500 resulted in 42% improved healing by day four and 61% better healing by day seven compared to saline controls. Keratinocyte migration showed 300% more stimulation in TB-500 groups versus saline controls within five hours at concentrations as low as 10 pg. [Malinda et al., 1999]
- Sikiric, P., et al. (2021) – “Stable Gastric Pentadecapeptide BPC 157 and Wound Healing” published in Frontiers in Pharmacology. The comprehensive review of BPC-157 confirms practical applicability for skin wound therapy including incisional/excisional wounds, deep burns, diabetic ulcers, and alkali burns, with demonstrated enhancements in proliferation, migration, and angiogenesis in vitro and significant improvements in wound contraction and reepithelialization in vivo with no reported toxicity. [Sikiric et al., 2021]
- Srivastava, D., et al. (2012) – “Cardiac Repair with Thymosin β4 and Cardiac Reprogramming Factors” published in Nature. The groundbreaking study demonstrated that thymosin β4 promotes myocardial survival in hypoxia and promotes neoangiogenesis, resulting in cardiac repair after injury. When combined with cardiac reprogramming factors, thymosin β4 and cardiac reprogramming technology may synergistically limit damage to the heart and promote cardiac regeneration through the stimulation of endogenous cells within the heart. [Srivastava et al., Nature, 2012]
- World Anti-Doping Agency (2010) – WADA Prohibited Substances List. Thymosin Beta-4 is classified as a prohibited substance under section S2 (peptide hormones, growth factors, related substances, and mimetics). The substance is prohibited because it meets multiple WADA criteria: it poses a potential health risk, it has demonstrated potential to enhance sport performance, and its use is considered to violate the spirit of sport. [WADA Prohibited Substances, 2010]
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