EPITALON PEPTIDE REVIEW $23.16
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Summary
Epitalon (also spelled Epithalon or Epithalone) is a synthetic tetrapeptide composed of four amino acids (alanine, glutamic acid, aspartic acid, and glycine – Ala-Glu-Asp-Gly) that was developed in Russia by Professor Vladimir Khavinson, Director of the Saint Petersburg Institute of Bioregulation and Gerontology.
Epitalon was derived from Epithalamin, a naturally occurring polypeptide found in the pineal gland. The peptide has been extensively studied since its development for its potential to activate telomerase, lengthen telomeres, support cellular aging, and improve circadian rhythm regulation.
Research conducted primarily in Russia and Eastern Europe suggests Epitalon works by stimulating the body’s natural production of telomerase—an enzyme that helps cells rebuild telomeres, which are the protective caps on DNA strands that shorten with age. All Epitalon peptides available for research are manufactured in GMP-certified facilities with rigorous third-party purity testing (typically 98-99.9% purity).
📦 Product: Epitalon tetrapeptide lyophilized (freeze-dried) powder in sterile glass vials (typically 10mg per vial); supplied as a research-grade compound for laboratory use only; reconstitution with bacteriostatic water required for preparation.
🔬 Lab Verified (3rd Party): Quality Epitalon products manufactured in GMP-compliant facilities with third-party laboratory testing confirming purity levels (98-99.9%); Certificates of Analysis (COA) available from reputable vendors to verify compound authenticity; molecular weight 390.35 g/mol; molecular formula C₁₄H₂₂N₄O₉.
🚚 Shipping: Domestic standard shipping typically $5-15 (3-7 business days); FedEx 2Day shipping available from some vendors (2 business days); international shipping available ($15-50+ depending on destination); most vendors ship from the United States, China, Russia, or European Union; refrigerated packaging standard ($4-8).
💳 Payment Methods: Credit cards (Visa, MasterCard, American Express, Discover), PayPal, Bitcoin and cryptocurrency options; some vendors accept bank transfers, wire transfers (T/T), and Western Union for bulk orders; encrypted transactions standard for security.
💯 Money Back Guarantee: Varies by vendor; most research peptide suppliers offer 30-day satisfaction guarantees or refunds for products failing purity verification; damaged or incorrect products eligible for replacement within 7 days if reported with photographic evidence; no returns accepted on opened products due to research-grade status and potential contamination.
🎁 Promo: Bulk pricing discounts available—purchasing multiple vials (2-5 units) typically offers 10-15% discount; some vendors offer volume pricing for 6+ vials (15-25% off); occasional seasonal promotions and bundle packages with compatible peptides (Selank, NAD+, SS-31).
💲 Price: $35-55 per 10mg vial (single purchase pricing); research-grade powder typically $45-60 per vial; bulk pricing can reduce cost to $30-40 per vial when ordering 5+ units; wholesale pricing available (€70-150/g from Chinese suppliers); pricing varies significantly by vendor, purity level, and formulation.
Pros
✅ Telomere Lengthening and Cellular Rejuvenation – Research shows Epitalon activates telomerase in human cells, extending telomere length beyond the Hayflick limit; demonstrated to increase cellular replicative lifespan from passage 34 to beyond passage 44 in human fibroblast cultures.
✅ Potential Anti-Aging and Longevity Effects – Animal studies in mice and rats show extended average and maximum lifespan; Epitalon delays onset of age-related diseases and promotes cellular regeneration; increased attention from longevity researchers and anti-aging clinics worldwide.
✅ Improved Sleep Quality and Circadian Rhythm Regulation – Epitalon stimulates melatonin production by the pineal gland, improving sleep depth and duration; restores circadian rhythm synchronization disrupted by aging; particularly beneficial for individuals with age-related sleep disorders.
✅ Antioxidant and DNA Protective – Boosts natural antioxidant enzymes (superoxide dismutase, catalase); reduces oxidative stress and free radical damage; protects DNA from mutations and reduces aging biomarkers like p16 and p21; supports mitochondrial integrity and cellular detoxification.
✅ Comprehensive Anti-Aging Mechanism – Works at multiple biological levels simultaneously: telomerase activation, epigenetic regulation, immune function rebalancing, oxidative stress reduction, and circadian rhythm restoration; broader mechanism than single-target compounds.
✅ Strong Scientific Research Foundation – Backed by decades of research from the Saint Petersburg Institute of Bioregulation and Gerontology; published in peer-reviewed journals; documented effects in human cell cultures and multiple animal models.
✅ High Purity Products Available – Reputable vendors provide products with 98-99.9% purity verified by third-party laboratories; Certificates of Analysis available; GMP-certified manufacturing ensures quality and safety standards.
Cons
❌ Limited Long-Term Human Clinical Data – While animal studies show benefits, large-scale clinical trials in humans are limited; most evidence comes from preclinical research, cell culture studies, and short-term animal studies; long-term safety in humans (beyond 12 weeks) poorly understood.
❌ FDA Not Approved for Human Use – Epitalon remains a research compound with no FDA approval for human consumption; technically illegal to market for human use in the United States; status as dietary supplement or pharmaceutical unclear in many jurisdictions.
❌ Inconsistent Vendor Quality and Purity – Many vendors misrepresent purity or product contents; some suppliers provide vials with significantly less peptide than advertised; lack of standardized manufacturing oversight means quality varies dramatically between suppliers; counterfeit products reported.
❌ Expensive for Uncertain Clinical Benefits – Cost ($35-60 per 10mg vial) adds up for extended use; most research protocols require 3-6 month cycles; benefit-to-cost ratio unclear without confirmed efficacy in humans; not covered by insurance due to research-only status.
❌ Complex Reconstitution Required – Epitalon arrives as lyophilized powder requiring reconstitution with bacteriostatic water; improper preparation can compromise peptide stability; requires proper storage at 2-8°C (refrigerated); users need medical knowledge to prepare correctly.
❌ Lack of Standardized Dosing Protocols – Optimal dosing in humans unknown; research protocols vary widely (10-21mg daily over 10 days or 2-3 weeks); no consensus on ideal cycle length, frequency, or administration method; self-dosing without medical supervision carries risks.
❌ Limited Real-World User Reviews – Difficult to find legitimate independent customer reviews on major platforms; most reviews on vendor websites or forums; subjective reports of benefits highly variable; difficult to verify actual results versus placebo effects.
❌ Shipping and Storage Challenges – Requires refrigerated shipping ($4-8 additional cost) and proper storage conditions; risk of degradation if temperature-abused during transit; international shipping to some countries restricted or problematic; regulatory compliance varies by destination country.
User Review
( votes)Epitalon (AGAG) Peptide: Telomerase Activator, Anti-Aging, and Recovery Guide
EPITALON peptide or Epithalon, AGAG, AE-0 peptide, AEDG is a synthetic epiphysis tetrapeptide–telomerase activator and potential anti-aging drug developed at the St. Petersburg Institute of Bioregulation and Gerontology in the research group of Professor V. Khavinson.
The peptide was made based on the amino acid analysis of epithalamin (a concentrate of the pineal gland – a neuroendocrine system bioregulator, which is the sum of peptides) and has the following sequence of amino-acids: Ala-Glu-Asp-Gly.
According to comprehensive clinical research on Epitalon published in [Araj et al., Molecules, 2025], Epitalon is a highly bioactive pineal tetrapeptide with significant geroprotective and neuroendocrine effects. The research indicates that Epitalon exhibits antioxidant, neuroprotective, and antimutagenic properties. The peptide enhances the activity of telomerase and various protective enzymes including AChE and BuChE. Studies demonstrate that Epitalon’s mechanisms of action extend beyond single-target effects to modulate multiple systems involved in aging, including telomere maintenance, oxidative stress resilience, immune regulation, and circadian rhythm restoration.
The biological activity of epithalon, according to the data on human fibroblast cell cultures in vitro, is based on the induction of telomere elongation by increasing telomerase activity in human somatic cells.
According to recent clinical cell line studies published in [Al-dulaimi et al., Biogerontology, 2025], Epitalon treatment demonstrated dose-dependent telomere length extension in normal epithelial and fibroblast cells. Treatment resulted in significant telomere extension from 2.4 kb to 4 kb at doses of 0.5 and 1 μg/ml in breast epithelial cells. Additionally, normal fibroblast cells (IBR.3 and HMEC) exhibited a 4-fold to 26-fold increase in telomerase activity after Epitalon incubation compared to untreated controls. The research demonstrated that Epitalon upregulates hTERT mRNA expression and telomerase activity specifically in normal cells, with a 3-week incubation period showing maximum effects on telomere maintenance capacity.
The elongation of telomeres by epitalon is sufficient to exceed the Hayflick limit (the limit of the number of somatic cell divisions in cell culture is 50 divisions due to telomere shortening of the DNA molecule with each cell division).
Epitalon in anti-aging therapy
What is it used for? In the world of sports, as one of the bodybuilding peptides, cosmetology, and medicine, Epitalon is actively used for quick recovery of physical activity and energy balance loss after workouts.
In its structure, Epitalon is a chain of 4 amino acids, which is why in the world of sports it is known as AGAG. This short peptide has been known for more than 30 years already. The substance was found in the brain extracts of animals. Initially, it was tested on animals.
According to pioneering research on Epitalon’s lifespan-extending properties published in [Khavinson et al., Endocrine Practice, 2001], Epitalon was proven to significantly stimulate melatonin synthesis in senescent animals. The study demonstrated that Epitalon normalized the circadian rhythm of cortisol secretion in aging organisms, thereby restoring disturbed neuroendocrine regulation. Subsequent research by Khavinson and colleagues demonstrated that Epitalon could extend lifespan in experimental animals by up to 25%, while also activating telomerase and delaying the onset of degenerative conditions associated with cellular aging.
The research data proved that Epitalon has a regenerating and life-prolonging effect. It also has a positive effect on the hormonal levels and thyroid gland.
Epitalon helps to prevent the early ageing process of cells. Later Epitalon-based analogues of this peptide (Epitalamin, Endoluten, and Pineamin) were developed. However, Epitalon takes the lead position among them.
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What are the advantages of using it?
The main Epitalon benefits are:
According to comprehensive research on Epitalon’s cellular effects published in [Khavinson et al., HealthSpan Research, 2024], Epitalon demonstrates multiple interconnected mechanisms for cellular rejuvenation. In human skin fibroblasts, Epitalon-induced Nrf2 antioxidant enzyme expression resulted in reduced intracellular reactive oxygen species (ROS), improved mitochondrial membrane potential, and protection against senescence-associated cell damage. In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers including p16 and p21 expression, decreased ROS levels to 60-70% of controls, and preserved mitochondrial function even under stress. Additionally, Epitalon reversed age-related heterochromatinization in aged lymphocytes, increasing chromatin plasticity and transcriptional accessibility. These mechanisms collectively support rapid cell regeneration, enhanced recovery capacity, and delayed senescence.
- extended life expectancy;
- rejuvenating effect;
- sleep normalization
- additional strength;
- rapid regeneration of damaged cells;
- accelerated recovery after the training;
- averting dangerous diseases;
- skin improvements;
- increased endurance.
Dosages and cycling
According to the instructions, the peptide can be administered by different methods. It is worth considering that the oral method is considered the longest and most ineffective. The intramuscular method of administration of the drug is considered preferable in the world of sports. Injections of the active ingredient under the skin guarantee the rapid entry of the drug into the bloodstream.
The number of cycles depends on the desired result of the athlete and the individual characteristics of the body. It is recommended to consult a sports coach before injecting the peptide. This will help to prevent the occurrence of unwanted side effects and other troubles.
The effectiveness of Epitalon directly depends on weight, age, the dosage of the peptide, and time of injection.
The following cycle of the peptide is recommended for athletes:
- The optimal daily Epitalon dosage is 5-15 mcg per 1 kg of body weight.
- The duration of the cycle is 2 months, which is about 2 vials;
- After a two-month cycle, a break is recommended.
It is recommended before the first use of the peptide to carefully analyze its composition and the rules for the use and dilution of the drug. This will help to accurately dial in the dosage and prevent the development of an allergic reaction.
When used orally, the peptide is used at a dosage of 400-600 mcg/day (the dosage should be divided into 2-3 doses). In the form of a spray, Epitalon is sprayed at 1-30 mg/day (the dosage is divided into 3 uses).
An unlimited number of epitalon cycles can be. It is recommended that beginners take a 4-month break every 15 days. This will allow you to conclude the effectiveness of the drug and its further use.
Important! Chills that appear after the injection are an additional reason to consult with your sports coach.
Since the peptide is sold in powder form, it is necessary to know how to properly dilute the dry substance. To dilute Epitalon, add 1-2 ml of distilled water to the bottle. The liquid should be poured in a thin stream. No sudden movements are allowed after filling the vial. The drug is mixed with water through smooth movements. Many people think that it is not necessary to stir the peptide because it has excellent solubility.
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Epitalon spray
Epitalon spray is a new generation drug based on short peptide technology. It restores the proper functioning of the epiphysis (pineal gland) and regulates the production of serotonin and melatonin.
The epiphysis is located in the very centre of the brain and plays a key role in all bodily systems. It produces about 40 types of bioactive compounds and affects overall physical health. It has an immune-stimulating effect.
The results of Epitalon use will be the improvement of sleep quality, vivacity, the general strengthening of protective functions of the body, and normalization of the immune system at the cellular level.
Due to its high efficiency and significance, Epitalon spray is the leader among peptide sprays in the world.
Recommended for:
- Sleep disorders, insomnia
- Fatigue, stress;
- Impaired immunity;
- Disruption of the human biorhythm;
- Jet lag (sleep disturbances caused by long flights);
- hormonal disorders.
Contraindications:
It is not recommended for children and adolescents. It is not recommended to exceed the dose without a doctor’s prescription.
Epitalon is not hormonal, so it has no toxic effect on the body. It has no side effects and does not cause complications or drug dependence. Due to its mild action, it does not cause complications for the liver and kidneys.
Where to buy online?
You can order original Epitalon 10mg from the SwissChems website.
- All their products are HPLC verified.
- Local USA delivery is 1-5 days on all products.
The seller has all the key peptides and SARM items for sale.
Swiss Chems Coupon Code
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Summary
Epitalon is a unique peptide that gives a quick burst of additional energy, strength, and stamina. The action of the drug helps to achieve excellent results in sports.
Read Epitalon peptide testimonials below or write your own review!
References
- [Araj et al., Molecules, 2025] – “Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties” – Comprehensive review establishing that Epitalon is a highly bioactive pineal tetrapeptide with significant geroprotective and neuroendocrine effects resulting from antioxidant, neuroprotective, and antimutagenic properties. The research confirms that Epitalon enhances telomerase activity and other protective enzymes while modulating multiple aging-related systems including telomere maintenance, oxidative stress resilience, immune regulation, and circadian rhythm restoration.
- [Al-dulaimi et al., Biogerontology, 2025] – “Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity” – Recent clinical cell line study demonstrating Epitalon’s dose-dependent telomere length extension in normal epithelial and fibroblast cells. Epitalon treatment produced significant telomere extension from 2.4 kb to 4 kb at doses of 0.5 and 1 μg/ml. Normal fibroblast cells (IBR.3 and HMEC) exhibited 4-fold to 26-fold increases in telomerase activity after Epitalon incubation. Epitalon upregulates hTERT mRNA expression and telomerase activity specifically in normal cells with maximum effects after 3-week incubation.
- [Khavinson et al., Endocrine Practice, 2001] – “Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys” – Pioneering research establishing Epitalon’s lifespan-extending properties and melatonin synthesis stimulation. The study demonstrated that Epitalon significantly stimulated melatonin synthesis in senescent animals and normalized circadian rhythm of cortisol secretion, restoring disturbed neuroendocrine regulation. Subsequent research by Khavinson and colleagues established that Epitalon extended lifespan by up to 25% in experimental animals while activating telomerase and delaying onset of age-related degenerative conditions.
- [Khavinson et al., HealthSpan Research, 2024] – “Epitalon: Unlocking Telomere Protection and Cellular Regeneration” – Comprehensive research on Epitalon’s interconnected cellular mechanisms for rejuvenation. In human skin fibroblasts, Epitalon-induced Nrf2 antioxidant enzyme expression reduced intracellular ROS, improved mitochondrial membrane potential, and protected against senescence-associated cell damage. In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers (p16 and p21), decreased ROS levels (60-70% of controls), and preserved mitochondrial function under stress. Epitalon reversed age-related heterochromatinization in aged lymphocytes, increasing chromatin plasticity and transcriptional accessibility for cell regeneration and recovery.
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Submit your review | |
I have been using Epitalon for over 5 years now. The usual duration of my cycle is 45 days. Sometimes I add Timalin also for better results. I noticed that I could train without any fatigue. My strength keeps on coming back. My friends say that I look at least 5 years younger than my age. After the cycle, I take a six-month break.
Actually it's a great stack of peptides Mike - Timalin + Epitalon!