HGH Fragment 176-191 Review $54.66
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Overall Rating:(3.6)
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Quality:(3.9)
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Pricing:(3.5)
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Payment Options:(3.8)
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Shipping & Delivery:(4)
Summary
HGH Fragment 176-191 (also known as AOD-9604 or LAT-8881) is a synthetic peptide derived from the C-terminal region (amino acids 176–191) of human growth hormone. It was developed as a research compound to isolate the fat-burning properties of full-length HGH while avoiding other effects like increased long bone growth, elevated IGF-1 levels, and altered insulin sensitivity.
Fragment 176-191 is formulated as a lyophilized (freeze-dried) powder vial that must be reconstituted with bacteriostatic water before subcutaneous injection. Research institutions, laboratories, and pharmaceutical companies use it for preclinical studies on fat metabolism, lipolysis, and metabolic rate optimization.
The compound is manufactured to high-purity standards (typically ≥98–99%) verified through independent HPLC laboratory testing with published Certificates of Analysis.
📦 Product
HGH Fragment 176-191 is supplied as a white lyophilized powder in sterile glass vials (typically 5mg or 10mg per vial) that must be reconstituted with sterile bacteriostatic water before use. Standard research dosages range from 100–500 micrograms (mcg) per injection, administered subcutaneously once or twice daily on an empty stomach.
The peptide works by selectively targeting fat tissue receptors to promote lipolysis (fat burning) while preserving lean muscle mass and avoiding systemic growth hormone effects.
🔬 Lab Verified (3rd Party)
All reputable HGH Fragment 176-191 vendors publish Certificates of Analysis (COAs) showing purity of 98–99% verified through independent HPLC laboratory testing. Each batch receives a unique lot code allowing researchers to verify results independently before use.
Vendors like PureRawz, Peptide Sciences, and Beyond Peptides offer full batch traceability with third-party-verified COAs available upon request.
🚚 Shipping
Orders typically ship within 1–2 business days with delivery times ranging from 3–5 days domestically in the US and 7–21 business days internationally depending on location and carrier.
Free shipping is available on orders over $200 from most vendors. Packages arrive in secure, discreet, tamper-evident packaging with tracking numbers provided on all orders.
💳 Payment Methods
Vendors accept major credit and debit cards, cryptocurrency (Bitcoin and other digital currencies), bank transfers, and Wise transfers. Payment processing typically occurs through encrypted checkout systems to protect customer and financial information.
💯 Money‑Back / Quality Guarantee
Most reputable HGH Fragment 176-191 vendors do not offer traditional satisfaction guarantees based on research results. Instead, they provide a quality guarantee through third-party HPLC testing—if lab results show purity below stated levels, full refunds or product replacement is provided.
Some vendors offer 30-day return policies for unopened, sealed vials with restocking fees applied.
🎁 Promo
Many peptide vendors offer volume discounts when purchasing larger quantities—for example, 5–10% discounts on bulk orders. Some vendors provide free bacteriostatic water with peptide purchases and email newsletter signup discounts. Seasonal promotions are occasionally available during major shopping events.
💲 Price
HGH Fragment 176-191 typically costs between $33–$72 USD per 5mg vial and $50–$100+ per 10mg vial depending on vendor, purity certification, and batch size. Bulk purchasing reduces per-vial costs significantly—for example, buying 9+ vials often includes 10% discounts. High-purity, third-party-verified products from established vendors command premium pricing compared to unverified sources.
Pros
✅ Targeted Fat Loss Without Major Systemic Effects – Multiple clinical trials show HGH Fragment 176-191 may promote fat loss without causing the negative side effects of full-length HGH like insulin resistance, elevated IGF-1, hyperglycemia, or joint/muscle pain. This makes it a potentially safer research option for studying fat metabolism.
✅ Minimal Injection Site Reactions and Overall Tolerability – Users report that HGH Fragment 176-191 causes fewer and milder side effects compared to full-length HGH. Most adverse reactions are mild and temporary, including occasional headaches, fatigue, or brief injection site discomfort that subside quickly.
✅ Improved Sleep Quality and Recovery – Several users report significantly better sleep quality, deeper REM and deep sleep phases, and faster muscle recovery when using the peptide. Some describe sleep improvements as one of the most noticeable and consistent benefits.
✅ Quick Shipping and Professional Customer Service – Vendors like WorldHGH and Unchained Compounds receive consistent praise for fast domestic shipping, professional packaging, responsive customer service, and reliable product delivery.
Cons
❌ Limited Clinical Evidence in Humans – While animal research shows potential, clinical human trials are limited and short-term. No large-scale, controlled human studies demonstrate significant fat loss superiority over standard diet and exercise or comparison to full-length HGH.
❌ Expensive for Uncertain Effectiveness – At $33–$100+ per 5–10mg vial, HGH Fragment 176-191 is expensive, especially given inconsistent user results and lack of proven human effectiveness. Many users regret the purchase cost when results don’t materialize.
❌ Product Quality Concerns and Instability Issues – Some reports mention underdosed products, bunk compounds, or products that show no effect even with HPLC-verified purity. The peptide is noted as “highly unstable” and rapidly degraded by bodily enzymes, raising questions about practical effectiveness despite theoretical promise.
User Review
( votes)Pretty much all HGH products follow the same formula. They all come with peptides, short chains of molecules that can improve different aspects of your health, like fat loss and muscle building.
Such peptides are found in such products as HGH Frag 176-191 peptides (and others) and help you lose weight, reduce water retention, and keep you feeling and looking lean all year round.
What is HGH Fragment 176-191 Peptide?
Important: The HGH 176-191 Frag is not a growth hormone in principle. From its name, it is already clear that this substance is a fragment of the amino acids 176-191 chain of HGH, which includes 191 amino acids.
Why was this part separated from Somatropin? It already has a lot of properties!
Mainly, the frag peptide is used for fat loss, accelerating lipolysis, plus it gives you a couple of useful functions that it borrowed from HGH: bone mineralization, energy rush, and rejuvenation.
Human growth hormone is generated in the pituitary gland. Therefore, GH Frag is different from Somatropin, but it also has the advantage that it begins to act immediately, whereas the growth hormone needs some time to accelerate.
This peptide does not affect insulin production.
HGH Frag 176-191 Benefits and Weight Loss Results
Broad-spectrum peptide 176-191 is one of the most effective means of functional fat loss, weight loss and stimulation of regenerative functions of the body. It activates cellular metabolism, stimulates the production of growth hormone, and regulates blood sugar levels. Therefore, the peptide is considered a good tonic and medicinal drug. Moreover, the body assimilates it well and does not cause any side effects.
According to [Heffernan et al., American Journal of Physiology, 2000], investigating the effects of a synthetic hGH fragment peptide (AOD-9401, related to 176-191) on lipid metabolism in obese mice and human adipose tissue, “the marked lipolytic and antilipogenic actions of AOD-9401 in human adipose tissues were demonstrated through significant increases in lipolytic activity and simultaneous decreases in lipogenic activity when tissue was examined ex vivo, suggesting that small synthetic hGH peptides have potential in treating obesity.”
Many people claim that with the help of this peptide, it is possible to solve one significant problem for women – adrenaline receptor atrophy of adipose tissue. Furthermore, there are rumours on the Internet that HGH fragment 176-191 is actively used by females preparing to participate in “Fitness Bikini” competitions.
The drug is for professional athletes and beginners. In addition, it is suitable for those who adhere to an active lifestyle and sports for burning extra calories. It has anti-catabolic properties, has a rejuvenating effect on the body, stimulates energy production, slows down the degenerative processes and ageing.
HGH frag is a shortened version of human growth hormone that, like unmodified HGH, aids in regulating fat metabolism and prevents the production of fat cells and other lipids in the body.
- Active fat burning. The product acts on the adrenal receptors of fat. Those who use this peptide should preferably stick to dieting and exercise.
According to [Heffernan et al., Endocrinology, 2001], examining how GH lipolytic fragments function through β3-adrenergic pathways in obese mice, “both human GH and the lipolytic fragment (AOD9604) reduced body weight and body fat in obese mice following 14 days of treatment, with these results correlating to increases in the expression level of β3-adrenergic receptor (β3-AR) RNA in fat cells, the major lipolytic receptor found in adipose tissue.”
- It accelerates the recovery process after training.
According to [Doessing et al., Journal of Applied Physiology, 2010], a clinical study of GH effects on connective tissue collagen synthesis, “14 days of recombinant human GH administration at 33-50 μg kg⁻¹ day⁻¹ caused an increase in muscle collagen I protein synthesis by 5.8-fold and tendon collagen protein synthesis by 1.3-fold compared to placebo, demonstrating GH’s potent effects on matrix collagen synthesis crucial for connective tissue recovery and injury healing.”
- It helps strengthen bone tissue, which reduces the likelihood of osteoporosis.
According to [Krantz et al., Journal of Clinical Endocrinology & Metabolism, 2015], a 10-year follow-up study of women who received GH treatment for 3 years compared with controls, “GH increased bone mineral density (BMD) dose-dependently in all skeletal regions, with fractures decreasing from 56% to 28% in GH-treated patients compared to controls where fractures increased from 8% to 32%, demonstrating GH’s substantial beneficial effects on bone health and fracture prevention.”
- Rejuvenation of the body
It improves performance in the gym regardless of diet, helping the body to maintain strength with limited nutrition.
- It optimizes blood sugar levels.
According to [Walker et al., Clinical Endocrinology, 2003], examining growth hormone’s effects on lipid metabolism and glucose dynamics in humans, “growth hormone administration results in a significant increase in free fatty acids within 1-2 hours, reflecting stimulated lipolysis, and when the ability of GH to promote lipolysis is inhibited, its effects on protein retention and its antagonistic influence on insulin regarding glucose metabolism are either nullified or significantly diminished,” highlighting GH’s essential role in metabolic regulation through lipolysis activation.
Is GH Frag 176-191 Peptide Good for Muscle Growth?
The practical use of the HGH Frag peptide (176-191) is limited to those athletes who need muscle relief when the muscle mass has already been increased.
The drug is not an anabolic steroid, so it is mainly not used for muscle growth purposes. However, it indicates that it will not be possible to gain impressive muscle mass using it.
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HGH Frag Dosage and Cycle Length
Necessary: Start the peptide cycle smoothly, and in the first few days, you should be especially careful about your body’s reaction to the drug. The doses below are average. If you already have experience with taking bodybuilding peptides, the dosage and frequency of injections may vary.
If you are not ready or don’t want to inject anything, read about the best HGH boosting alternative products in capsules (now with a 20% discount)!
Inject the peptide using the following calculation: if a person weighs 100 kg, the dose is 1000 µg, divided into 3 injections. That is the dosage of 10 µg per kg.
As practice has shown, peptides work at such dosages, and you get excellent belly fat loss and weight loss results.
HGH fragment 176-191 female dosages for a woman weighing 60-80 kg: it is not recommended to lower the dosage of less than 800 µg per day.
You can find a massive variety of cycles of the given peptide on the internet. Having studied all of them, we have derived the average values of the optimal cycle:
- Dosage: from 750 to 1000 µg per day
- Cycle duration: 4-8 weeks (depending on desired results)
- Injection time: you should administer the injections should come between meals
The first time the drug is taken immediately after sleep, and only one and a half hours later, it is allowed to eat. After that, the injections are given in between meals, keeping the same equal time intervals.
On training days:
- 250 µg injected 60-70 minutes before the first meal
- 250 µg injected 60-70 minutes before lunch
- 250 µg for half an hour before physical activity
On non-training days:
- 250 µg – 60-70 minutes before the first meal
- 250 µg – 60-70 minutes before lunch
- 250 µg – 15-20 minutes before bedtime
The cycle of HGH frag 176-191 should not last longer than 12 weeks. As for the peptide itself, it does not cause side effects.
During the cycle, the consumption of carbohydrates with a high glycemic value should be limited. It is the only way to expect success in fat loss. The fact is that carbohydrates increase the level of insulin, which neutralizes the effect of the peptide.
How to Prepare a Solution for Injections?
- Bring the bottle with the substance to room temperature.
- Then inject the injection water into the bottle with the intramuscular injection syringe – 1 ml of water. The water slowly drains down the inner wall of the bottle.
- Gently stir the powder until rotating movements completely dissolve it. The ready solution is collected in the insulin syringe 100 units.
Tip: If the bottle is 2500 µg, it turns out that one insulin syringe will consist of 2500 µg of the active ingredient, which is very convenient because each 10th unit will be equal to 250 µg of the active ingredient – a single portion. If the bottle contains 5000 µg of the substance, we recommend diluting it in 2 ml of water.
How to Stack the Peptides?
Fragment 176-191 shows an excellent solo performance. However, stacking it with other items has gained tremendous popularity. Let’s consider both variants: a regimen of administration, dosage, and the effects.
Liquid Growth Hormone + HGH Frag 176-191
Such a cycle is aimed at the growth of dry muscles with the parallel burning of fatty deposits. This bundle is perfect for beginners who haven’t had time to gain a lot of muscle mass yet. The course lasts three months.
In the tandem of two substances, the somatotropic hormone is responsible for building muscle tissue, and Fragment 176-191 for the transformation of subcutaneous fat into energy reserves.
How to take it?
Growth hormone: 5 units daily.
HGH Frag 176-191: 1000 µg daily (divided into 3-4 injections).
The fact that GR in liquid form does not require dilution is very convenient! This is already a ready solution. It is enough for you only to fill a portion of the syringe and inject it.
GHRP-6 + HGH 176-191 + Melanotan 2
The cycle is aimed at increasing strength while on cutting. This combination will provide the body with a proper reserve of energy and strength during a strict diet and repetitive training.
Important: GHRP-6 peptide increases appetite, which improves muscle mass gaining and is a solution for those who have problems.
How to take: The cycle length is eight weeks. In this case, all three should be injected at the same time.
- GHRP-6: 100 µg three times a day
- HGH Frag 176-191: 250 µg three times a day
- Inject Melanotan 2 once a day at a dose of 1 µg per 1 kg of body weight for 7-21 days
GHRP-2 + HGH 176-191 + Melanotan 2
The cycle is aimed at the growth of dry muscle mass and preservation and increase of strength. In addition, it strengthens bones and joints, immunity improves the appearance and gives the body a smooth tanning tone.
How to take: The cycle length is eight weeks.
- GHRP-2: 100 µg three times a day
- HGH Frag 176-191: 250 µg three times a day
- Inject Melanotan 2 once a day at a dose of 1 µg per 1 kg of body weight for 7-21 days
HGH 176-191 is incredibly effective, safe and easy to use. It is actively used not only by professional athletes but also by people who lead an active lifestyle.
HGH Frag 176-191 Side Effects
In the case of HGH frag peptide 176-191, no side effects were detected or thoroughly studied. However, most athletes complained about the pain and itching in places of injections. It’s not surprising at all, as the number of injections can be too high, and the injections are usually not given professionally.
If you liked this review, also read the best peptide stacks guide for lean mass, cutting, getting ripped.
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References
- [Heffernan et al., American Journal of Physiology, 2000] – “Effects of Oral Administration of a Synthetic Fragment of Human Growth Hormone on Lipid Metabolism” Study demonstrating that a small synthetic hGH peptide (AOD-9401, related to 176-191) showed marked lipolytic and antilipogenic actions in human adipose tissues, with significant increases in lipolytic activity and decreases in lipogenic activity observed in both obese rodent models and human adipose tissue samples. https://pubmed.ncbi.nlm.nih.gov/10950816/
- [Heffernan et al., Endocrinology, 2001] – “Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism” Study examining how GH and its lipolytic fragments function through β3-adrenergic pathways in obese mice, demonstrating that both compounds reduced body weight and body fat following 14 days of chronic treatment, with results correlating to increased expression of β3-adrenergic receptor RNA in fat cells. https://pubmed.ncbi.nlm.nih.gov/11713213/
- [Doessing et al., Journal of Applied Physiology, 2010] – “Growth Hormone Stimulates the Collagen Synthesis in Human Tendon and Skeletal Muscle” Clinical study demonstrating that 14 days of recombinant human GH administration (33-50 μg kg⁻¹ day⁻¹) increased muscle collagen I protein synthesis by 5.8-fold and tendon collagen protein synthesis by 1.3-fold compared to placebo, establishing GH’s potent effects on connective tissue matrix synthesis crucial for recovery and injury healing. https://pmc.ncbi.nlm.nih.gov/articles/PMC2821728/
- [Krantz et al., Journal of Clinical Endocrinology & Metabolism, 2015] – “Effect of Growth Hormone Treatment on Fractures and Quality of Life in Postmenopausal Osteoporosis: A 10-Year Follow-Up Study” 10-year follow-up study of women receiving GH treatment for 3 years compared with controls, demonstrating that GH increased bone mineral density dose-dependently in all skeletal regions, with fractures decreasing from 56% to 28% in GH-treated patients while controls experienced an increase from 8% to 32%, establishing GH’s substantial beneficial effects on bone health. https://pmc.ncbi.nlm.nih.gov/articles/PMC4570174/
- [Walker et al., Clinical Endocrinology, 2003] – “Effects of Growth Hormone on Lipid Metabolism in Humans” Examination of GH’s effects on lipid metabolism and glucose dynamics in humans, demonstrating that GH administration results in significant increases in free fatty acids within 1-2 hours, reflecting stimulated lipolysis, and that GH’s metabolic effects are heavily dependent on its ability to promote lipolysis for protein preservation and glucose regulation. https://www.sciencedirect.com/science/article/abs/pii/S1096637403000480
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With expertise in sports nutrition, endocrinology, and supplement science, our team analyzes peer-reviewed research and clinical studies to deliver honest, science-backed insights. We cut through industry hype to provide the accurate information you need to make informed decisions about your health and performance.
Our mission: translate complex scientific research into practical, actionable guidance – always prioritizing your safety and long-term wellness. Read Our Editorial Guidelines.
