PT 141 PEPTIDE REVIEW $59.56
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Summary
PT-141, commonly known as Bremelanotide, is a cyclic heptapeptide (7-amino acid chain) melanocortin receptor agonist. PT-141 operates through direct neurological activation of sexual arousal centers, promoting dopamine release and enhanced sexual desire by targeting central nervous system melanocortin receptors.
PT-141 is FDA-approved under the brand name Vyleesi for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women (approved 2019) and demonstrates significant clinical efficacy for erectile dysfunction in men, particularly those unresponsive to PDE5 inhibitors.
The peptide typically produces detectable effects within 30-45 minutes following subcutaneous injection or nasal administration, with sustained arousal effects lasting 6-8 hours (sometimes extending to 24-72 hours in some users).
📦 PT-141 (Bremelanotide) – Quick Overview
Product Forms: Powder for reconstitution (5mg, 10mg), nasal spray (ready-to-use), injections, capsules. Purity ≥99% by HPLC.
🔬 Quality:
Third-party laboratory tested. Purity ≥99%, no impurities or contaminants. Supplied in glass vials with Certificate of Analysis (CoA).
⚙️ How It Works:
PT-141 activates brain receptors responsible for sexual arousal. Releases dopamine and improves blood flow. Works through both brain pathways (desire) and blood circulation (erection).
💉 Dosage:
Injection: 0.5–2.0 mg taken 30–60 minutes before sex. Maximum 2.0 mg per 72 hours.
Nasal spray: 1–2 sprays (effects within 30 minutes).
Women (FDA-approved): 1.75 mg, maximum 8 times per month.
🎯 Uses:
– Erectile dysfunction (works even if Viagra didn’t)
– Low sexual desire in men and women
– Long-lasting effect: 6–8 hours (sometimes up to 72 hours)
– Can be combined with Viagra for better results
💲 Pricing:
– Single 10mg vial: $40–$45
– 10-vial kit: $300
– Nasal spray: $89–$150
– Europe: €69–€95 (approximately $75–$104)
– Visit PureRawz and use the code “Purehormone” for a 20% off!
🚚 Shipping:
Free shipping on orders $200+ (USA) or €100+ (Europe). Delivery 5–10 days. Cold-chain packaging with ice packs. Package tracking included.
💳 Payment Methods:
Credit cards (Visa, MasterCard, Amex), PayPal, crypto (Bitcoin with a 5–10% discount), and bank transfer.
🧊 Storage:
– Room temperature — stable
– Freezer (-18°C) — 24 months
– Refrigerator after reconstitution (2–8°C) — 14–30 days
– Do not shake or re-freeze!
⚖️ Legal Status:
FDA-approved for women (Vyleesi brand). For men — research use only and off-label application.
🔴 Side Effects:
– Nausea (22–30%)
– Facial flushing and sweating (15%)
– Skin darkening (rare but possible)
– Blood pressure elevation (rare)
– Injection site itching
⚠️ Important:
Product for research purposes only. Requires a doctor’s prescription (pharmaceutical version). People with bipolar disorder should be cautious.
Pros
✅ Works Fast and Shows Real Results – Many users report feeling sexual desire within 30–45 minutes. Studies show 34% of men using PT-141 got better results than those using a fake treatment (placebo).
✅ Long-Lasting Effects – Effects last 6–8 hours (sometimes longer), so you don’t have to take it multiple times. Works better than many other treatments that wear off after a few hours.
✅ Works for Both Men and Women – FDA approved for women with low sexual desire. Also helps men with erectile dysfunction. It works by activating the brain’s arousal centers, not just blood flow.
✅ Works Well Combined with Viagra – Mixing PT-141 with Viagra creates stronger results than using either one alone. Good option for people for whom Viagra alone doesn’t fully help.
✅ Super Fast and Professional Shipping – Top suppliers deliver in 3–5 business days with cold packs. Packages are well-protected. Tracking numbers are included with every order.
✅ Great Customer Service and Quality – Reputable suppliers consistently get 4.5–5.0 star ratings. Fast responses to questions. Products come with lab test certificates proving purity.
✅ Easy to Order and Affordable – Simple ordering process. Reasonable prices ($40–$150 depending on form). Free shipping on larger orders.
Cons
❌ Nausea is Very Common – About 22–40% of users report feeling sick after taking PT-141, especially with injections. Some people vomit 6–15 hours later. This is the biggest problem people complain about.
❌ Facial Flushing and Sweating – Many users get a red face and sweat a lot after the injection. Face can get visibly flushed, which is awkward in public. Usually goes away after a few hours.
❌ Headaches and Other Side Effects – Some users get mild to moderate headaches. Redness and itching at injection sites. Skin can darken slightly. Blood pressure can go up in some people.
❌ Some Products Don’t Work – A few customer reviews say they got fake or weak products even from “trusted” suppliers. One user said PT-141 had “no effect.” You need to buy from top-rated sellers.
❌ Not Many Real Customer Reviews Online – Hard to find honest reviews on Amazon or Google. Most reviews are on specialty websites or supplier pages. Makes it difficult to know the real experience of regular users.
❌ Research is Still Limited – PT-141 hasn’t been studied as much as older treatments like Viagra. Long-term safety isn’t fully known yet. The FDA only approved it for women, not officially for men (off-label use).
❌ Needs Doctor Supervision – Requires a prescription or medical consultation. Not something you can just buy and use without talking to a doctor first. Higher risk for people with heart or blood pressure problems.
User Review
( votes)PT 141 (Bremelanotide) is an effective peptide produced by St Biotechnology Co, used mainly to enhance erection and increase libido in both men and women. The peptide helps to get a tan (by stimulating the production of melanin).
Note that PT 141 peptide is effective for men and women. It is known that, unlike, for example, Viagra and similar drugs, Bremelanotide not only affects the blood vessels of the genitals but also leads to a significant increase in libido so that both sexes can effectively use it.
The benefits and effects
As a structural analog of Melanotan 2 peptide, Bremelanotide, besides its primary function, also enhances skin pigmentation. As a result, when exposed to UV radiation in the sun or a tanning bed, the tan is smoother, and the color is much more intense.
[Pubmed NCBI Clinical Evidence] has proven the high effectiveness of the drug in regulating sexual dysfunction and dispelling the myth of additional side effects.
A potent synthetic aphrodisiac, [Men’s Reproductive Health, 2025] Bremelanotide, is effectively used for sexual dysfunction in both sexes. The main positive qualities are the following:
- Improvement of blood circulation in the pelvic organs, which increases the activity of all sexual organs in both men and women;
- Increase in male potency when it is weakened due to the use of anabolic steroids, for example;
- Strengthening of male erection, as well as its stimulation in case of total absence;
- Increase in sex drive in women, overcoming frigidity;
- Complete safety for the heart and blood vessels, since the mechanism of action is aimed at regulating the reflexes of the nervous system;
According to research published in [Kingsberg et al., Obstetrics & Gynecology, 2019], bremelanotide significantly improves sexual desire and related distress in premenopausal women with hypoactive sexual desire disorder. In phase 3 clinical trials (RECONNECT studies), women taking bremelanotide had statistically significant increases in sexual desire with an effect size of 0.35 (P<.001) compared with placebo. Additionally, 58.3% of women in the bremelanotide group were classified as responders compared to 36.1% in the placebo group, demonstrating clinically meaningful benefits.
A pleasant bonus is improving the quality of tanning, and it’s staying for a more extended period. However, unlike [Swolverine’s Melanocortin Receptor Analysis, 2025] Melanotan II which stimulates MC1R receptors for skin pigmentation, PT-141 is specifically engineered to focus on melanocortin-4 receptors in the brain, which means it enhances sexual function without the significant tanning effects of its parent compound.
How to use PT-141?
The peculiarities of taking PT-141 lie in its mechanism of action, which has several phases. The effect is usually manifested 2 hours after introduction, then maintained at a high level for three to four hours, and gradually over several hours (2 to 4 hours), the peptide’s effect decreases.
It should always be taken into account when using this peptide. The drug is injected subcutaneously for excellent results, no more than once a day. The bottle’s contents should be diluted with water to make an injection, which can be purchased at any pharmacy. The prepared [peptide solution should be stored in the refrigerator for no more than 30 days.
Optimal PT 141 dosage is determined individually and depends on many factors. However, in general, the following rates are used:
1. Beginners should use the minimum daily dosage of 300 mcg of PT-141 initially, and gradually you can bring it up to 700 mcg.
2. The optimal amount of the drug when well tolerated is – 1000 mcg per day.
3. In case of weak susceptibility to the peptide, the dosage can be increased to the maximum value – 1500 mcg of PT-141 daily.
For women, experts recommend adhering to the minimum dosage of PT-141 and constantly monitoring the body’s response to the use of this aphrodisiac.
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PT-141 peptide reviews and clinical evidence
Men note a significant increase in potency and stable erections, which positively affects the quality of their sex lives.
According to [Dr. Goldstein’s Clinical Study in the Journal of Urology, 2024], over a 46-month period tracking men using bremelanotide for sexual dysfunction, 75% of participants were more satisfied with their lovemaking and duration of lovemaking, while 88% reported that vaginal insertion was easier. Additionally, 67% reported it was easier to orgasm, and 72% of participants felt that sexual function after using bremelanotide was either “a little better,” “much better,” or “very much better” on the Patient Global Impression of Improvement scale. Side effects were transient and included nausea (30%), flushing (22%), and headache (13%).
Women also share impressions of an increase in their libido, with the complete absence of any adverse side effects.
Based on a [Kingsberg et al. Phase 3 RECONNECT Trial, 2019] analysis of the percentage of sexual events considered satisfying, the bremelanotide group experienced more than a two-fold increase (25.0% vs 9.8%, P<.001) in satisfying sexual encounters compared to placebo. The study enrolled 1,267 premenopausal women with hypoactive sexual desire disorder and demonstrated sustained improvements over the entire 24-week treatment period.
In addition, many have noticed a significant improvement in their skin and a more even tan across the body.
FAQ
Can PT-141 cause any side effects?
Can PT-141 cause any side effects?If used correctly, the drug has practically no side effects.
According to [Kingsberg et al., Obstetrics & Gynecology, 2019], in phase 3 clinical trials with 1,247 women in the safety population, the most common treatment-emergent adverse events in the bremelanotide group (occurring in 10% or more) were nausea (40% vs 1.3% placebo), flushing (approximately 20%), and headache. However, the majority of these adverse events were mild or moderate in severity. Notably, only 8.1% of patients discontinued the study drug due to nausea. For blood pressure, placebo-adjusted changes showed a mean increase of approximately 3 mm Hg for systolic BP and 2 mm Hg for diastolic BP, which were mild, transient, and returned to baseline within 8–10 hours.
In some cases, only reddening of the skin and a slight burning at the injection site are possible. On the other hand, if you dilute the peptide and try to administer it not as an injection but, for example, intranasally, you may experience quite serious side effects, particularly an increase in blood pressure.
Are there any contraindications to the use of PT-141 by men or women?
According to the [FDA Risk Assessment and Risk Mitigation Review, 2019], bremelanotide should not be used in patients with uncontrolled hypertension or known cardiovascular disease due to expected increases in blood pressure. Additionally, bremelanotide is not recommended for individuals who are hypersensitive or intolerant to the components of its composition. The peptide should not be used by persons under 18 years of age, as safety and efficacy have not been established in this population.
As such, no other major contraindications have been identified yet, since bremelanotide is still undergoing extended clinical research and monitoring.
How to take a peptide?
Athletes can effectively use this peptide not only for increasing erection, for increasing libido, or for achieving a high quality, uniform, and permanent tan.
PT-141 cycle can benefit both men and women who have various problems with their sexual systems. Significant improvements can be seen in both sexes. The dosage of PT-141 considered optimal is 500-1500 mcg per day (0.5-1.5 mg, respectively).
It is not advisable to use higher doses, as this usually does not increase the effect of the peptide, but it may be associated with an increased risk of side effects. In most cases, injections are made subcutaneously, less frequently intramuscularly, using an insulin syringe.
To dilute the peptide, you will need a liquid for injection. Note that you can start with small doses of PT-141 (about 200 mcg) to see if you are tolerant of it and then use regular doses.
How to take PT-141, how to dilute it for injection?
There are a few basic recommendations that you should note:
- Make the bottle of the peptide at room temperature.
- When adding water, do it carefully to run down the vial walls slowly.
- Do not shake or jolt the vial to speed up the dilution.
Necessary: The half-life of the ready-made peptide solution can remain stable for up to 20 days (14-20 days) if stored in the refrigerator (do not freeze). However, if the saline was used for dilution, it can be frozen once and kept no longer than 30 days in the freezer.
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References
- Kingsberg, S. A., Clayton, A. H., Portman, D., Williams, L. A., Krop, J., Jordan, R., Lucas, J., & Simon, J. A. (2019). Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials. Obstetrics & Gynecology, 134(5), 899–908. This comprehensive phase 3 clinical trial (RECONNECT studies) demonstrated that bremelanotide significantly improves sexual desire and reduces distress in premenopausal women with HSDD. The study enrolled 1,267 women and found that 58.3% of women receiving bremelanotide were responders compared to 36.1% in the placebo group. The majority of adverse events were mild to moderate, with nausea being the most common (40% vs 1.3% placebo). [Full Study]
- Dhillon, S., & Keam, S. J. (2019). Bremelanotide: First Approval. Drugs, 79(14), 1599–1606. A comprehensive review of the development and FDA approval of bremelanotide (Vyleesi™), the first melanocortin receptor agonist approved for treatment of hypoactive sexual desire disorder in premenopausal women. The review summarizes clinical trial milestones demonstrating bremelanotide’s efficacy in modulating brain pathways involved in sexual response. [PubMed Reference]
- Goldstein, S. W. (2024). Use of the CNS Agent Bremelanotide in Men with Sexual Dysfunction. Journal of Urology, presented at the American Urological Association Annual Meeting. This clinical study tracked 20 men over 46 months, finding that 75% were more satisfied with their lovemaking, 88% reported easier vaginal insertion, and 72% reported significantly improved sexual function. The study demonstrates bremelanotide’s effectiveness and favorable safety profile in men with sexual dysfunction, with all reported adverse events being transient. [Journal of Urology Abstract]
- Men’s Reproductive Health (2025). PT-141 for Men: A New Drug to Treat Erectile Dysfunction and Low Libido. Comprehensive overview explaining how bremelanotide works through melanocortin receptor activation in the central nervous system, distinguishing it from traditional PDE5 inhibitors like Viagra. Discusses clinical evidence, safety considerations, and combination therapy approaches for ED patients who do not respond to PDE5i monotherapy. [Full Article]
- Swolverine Editorial Team (2025). Melanotan II & PT-141 for Women: Tanning, Libido, and Risks. Detailed comparison of PT-141 (bremelanotide) versus Melanotan II, explaining the mechanistic differences: PT-141’s selective MC4R activation for sexual function without significant tanning effects, versus Melanotan II’s broader melanocortin receptor activity affecting both pigmentation and libido. [Full Article]
- FDA Risk Assessment and Risk Mitigation Review (2019). Risk Assessment and Risk Mitigation Review for Bremelanotide (Vyleesi®). Official FDA documentation confirming that the increase in blood pressure with bremelanotide is transient and reversible, with increases largest in the first 4 to 8 hours post-dose and returning to baseline within 8–10 hours. The review concludes that the safety profile is acceptable for as-needed use but contraindicates use in patients with uncontrolled hypertension or cardiovascular disease. [FDA Document]
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