Is GenF20 Plus HGH Spray Good for Bodybuilding?

Wondering if GenF20 Plus HGH Spray works for building muscle? Short answer: It might help, but it’s no magic potion. This spray aims to boost your body’s natural growth hormones, which can support muscle growth, faster recovery, and better stamina—key stuff for lifting gains. But here’s the catch: results vary, and it won’t replace hard training or a protein-packed diet. Let’s break down how it works, what users say, and whether it’s worth adding to your gym bag.

Genf20 Plus is an HGH supplement by Leading Edge Health backed up by science. I will explain why and how it works. You will be disappointed if you are looking to instantly drop 20 years off your age or build lots of muscle quickly.

The supplement is a great product, but no product can do that! So, before we tell you if this HGH booster is excellent for muscle building or your anti-aging program, has dangers and side effects or not – read the first part of our GenF20 Plus reviews to understand what this product is all about?

What is Genf20 Plus?

It is a natural product that usually pushes your body to increase HGH production (Human Growth Hormone). HGH can be a fantastic product when joined with exercise, meditation, and healthy eating to make a superior, more beneficial, better balanced you. Of the numerous GH supplements available, not many have the science, supports, or notoriety of HGH. Read down below to find out how it works.

The Aging Process

Aging affects our wellbeing and keeps on being a worry for the majority of us. We as a whole want to look and feel improved and more youthful. Nonetheless, we think about the impact of our years as we begin to age. At first, it is pretty much nothing, yet it doesn’t take long before we start to see the difference truly.

We discover we have more wrinkles, put on weight, particularly in our waistlines, lose muscle strength, start getting tired quickly, don’t rest soundly, and generally speaking, begin to show signs of aging.

The Science Behind GenF20 Plus

There is plenty of science to back up the GenF20 Plus formulae.

According to [Sonawane et al., Dovepress, 2015], a randomized controlled study on GenF20 Plus, “GenF20 Plus increased serum IGF-1 levels in subjects ≥40 years of age who physiologically have reduced IGF-1 levels. The adjusted percentage change in IGF-1 was 28.57% in the GenF20 Plus group as compared to -0.55% in the placebo group (P<0.05), demonstrating statistically significant improvements in subjects over 40 years of age.”

The Genf20 Plus manufacturers claim that it is made from 100% natural ingredients and works by helping to increase your HGH levels naturally in the pituitary gland.

Genf20 Plus Ingredients

✔️ Colostrum

Clinical studies and testimonials from people taking colostrum reveal that it may be one of the most impactful natural substances discovered to date, capable of helping athletes to achieve the results they’ve dreamed of.

According to [Yalçintaş et al., PMC, 2024], “Bovine colostrum supplementation increases muscle development in athletes. IGF-1 shows primary mechanisms in modulating muscle size and function through altering protein synthesis and degradation processes, with research showing that colostrum consumption led to significantly greater increases in lean body mass than whey protein alone in study participants.”

Many bodybuilders and fitness experts claim that colostrum is the most effective way to build strong muscles. It can even eliminate the need to use illegal (and dangerous) steroids, they say.

IGF-1 (insulin-like growth factor) found in milk has a much better anabolic effect than any other substances known up to now, even steroids. IGF-1 leads to an increase in muscle mass and strength. Cow’s colostrum has a higher concentration of IGF-1 compared to human colostrum, and their structure is almost identical. Human and cow’s IGF-1 differ in only three of the 67 amino acids that make up the chain of their molecules. Because of this similarity, bovine IGF-1 is just as effective as human IGF-1.

✔️ Astragalus root

The dry extract of Astragalus membranaceus in experimental and therapeutic dose of 50 mg/kg increases nonspecific body resistance to extreme factors of various etiology:

• immobilization and psychoemotional stress,
• intense physical exercise,
• hypercapnic,
• hemic and tissue hypoxia.

According to [Latour et al., PMC, 2021] in a study on elite rowers from the Polish Rowing Team, “Astragalus Membranaceus Root (AMR) supplementation restored immunological balance in strenuously trained athletes through stabilization of NK and Treg cells, preventing the typical immunosuppression that occurs during intensive training, with results showing improved Th1/Th2 immune balance and reduced susceptibility to upper respiratory tract infections.”

It has pronounced immunomodulatory properties, increasing the activity of humoral, cellular, and macrophage immunity. In addition, the cytoprotective effect of a dry extract of Astragalus is an increase in the physical endurance of animals. It is associated with an increase in the rate of ATP resynthesis, the accumulation of carbohydrate reserves of cells, a decrease in the severity of metabolic acidosis.

✔️ Phosphatidylcholine

Phosphatidylcholine is a phospholipid that maintains the fluid and plastic properties of the cell and slows its aging process. It is part of lecithin.

✔️ GTF Chromium

It is necessary to normalize carbohydrate metabolism, harmonize sugar levels, and prevent heart and vascular diseases. The main active ingredient of the product regulates insulin levels, improves the nervous system and sperm activity.

✔️ Amino-acids boost growth hormone release.

• L-Arginine
• L-Glutamine
• L-Glycine
• L-Lysine
• L-Ornithine
• L-Tyrosine

L-Arginine:

According to [Chromiak et al., ScienceDirect, 2002], “Specific amino acids, such as arginine, lysine and ornithine, can stimulate growth hormone (GH) release when infused intravenously or administered orally. Intravenous administration of arginine resulted in more than 20-fold increase in plasma GH in females, and 8.6-fold increase in males, making these amino acids key components in natural HGH releaser formulations.”

L-Arginine has many benefits, such as it improve the immune system, boosting up fat burning process, improving fertility in men, and promoting healing. The human body does not produce arginine naturally; that’s why one has to take it from the diet.

L-Ornithine: The ingredient has a double effect as compared to arginine in increasing HGH levels. It works great combined with lysine, arginine, and glutamine.

L-Tyrosine: The production of Thyroxin maintains the metabolism rate and reduces depression.

L-Lysine: It combines with arginine to boost up its effect up to 10 times. It can improve the immune system and the working of genital organs.

L-Glutamine: It is an amino acid that is used by the body during stress. The primary purpose of this ingredient is to build and maintain muscles and the growth and division of cells. It can increase energy levels and mental focus. Some studies have shown that L-Glutamine can reduce cholesterol levels, reduce blood pressure, minimize heart problems, diabetes and improve immunity.

L-Glycine: Acts as a stimulatory agent to secrete HGH by the pituitary gland. It gives a soothing effect to the brain and improves the health of the prostate gland.

✔️ GABA

It is also known as Gamma-Aminobutyric Acid, which helps nerve cells communicate with the central nervous system.

According to [Powers et al., PMC, 2008], “Oral administration of GABA reportedly elevates both resting serum growth hormone concentrations and post-exercise GH response. Research demonstrates that ingested GABA elevates both immunoreactive GH (irGH) and immunofunctional GH (ifGH) concentrations at rest, and augments the resistance exercise-induced GH response, playing a vital role in the production of HGH.”

✔️ Pituitary Powder

An anterior pituitary powder ingredient of Genf20 Plus can boost the release of HGH and stop aging by toning up muscles.

✔️ Phosphatidyl Choline

It is an emulsifier that helps in the absorption of other nutrients included in the supplement. It emulsifies and breaks down fats in the body to prevent the formation of gallstones, liver diseases, heart problems, memory loss, and stress.

✔️ Deer Velvet Antlers

According to [Jo et al., PMC, 2021], “Deer antler extract increased the expression of MyoD1, Myf5 and myogenin genes, inhibited muscle atrophy, and promoted muscle differentiation. The extract contains high concentrations of IGF-1, IGF-2, amino acids, and over 390 micro and macro elements that support muscle growth and tissue regeneration.”

• It is the most natural hormonal adaptogen and tonic.
• Help to reduce cholesterol and body fat.
• Quickly regenerate cartilage, bone, and muscle tissue.
• Restore and improve the elasticity of blood vessels.
• Increase the growth of muscle mass and increase strength.
• Contribute to the production of sex hormones.
• They are not doping.
• Improve the pumping function of the heart
• Increase endurance
• Contain more than 390 micro and macro elements, including amino acids, IGF1 and IGF2 growth factors, growth hormone, cartilage, and nerve growth factors.
• Increase human bioenergetics!

Learn More About Genf20 Plus Ingredients

Does Genf20 Plus Work for Muscle Building?

What results in bodybuilding can expect athletes from using it? From the above ingredients of the supplement, you have already guessed that Genf20 Plus has a pronounced anabolic effect in addition to the anti-aging effect. This product will increase the natural growth hormone production and contribute to the faster building of lean muscle mass, together with protein shakes.

It will also increase your strength, endurance, and energy generation. We advise you to use Genf20 Plus for muscle building with a well-balanced diet and other workout nutrition.

GenF20 Plus Clinical Studies

The clinical evidence demonstrates that GenF20 Plus can modestly increase IGF-1 levels in adults 40 years and older when adjusted for baseline values, and it shows acute HGH-stimulating effects measured within 90 minutes of administration. However, the practical significance of these hormonal changes in terms of meaningful improvements in body composition, cognitive function, energy, or other quality-of-life measures remains uncertain based on the available 12-week studies.

HGH ties to the target cell receptors, focusing on fat cells and bonding with them, meddling with the capacity of fat to develop, and breaking down triglycerides. Furthermore, HGH increases IGF-1 levels, which is the insulin-like development factor hormone the liver secretes along with the development-related impact of HGH.

Doctors have been trying to reverse the signs of aging for years. According to a study published in the New England Journal of Medicine to show the effects of HGH, the results were promising. People of ages 61 and above were divided into groups and were given synthetic HGH injections for 6 months and were later compared to a control group.

According to the results, an increase in lean muscle mass, a reduction in fat mass, an increase in bone density, and an improvement in skin thickness were observed.

According to this study, one cause of aging is the dropping of HGH levels in the body. Hence, when the level of HGH is increased, it reduces some of the signs of aging.

According to [Rudman et al., New England Journal of Medicine, 1990], the landmark study on human growth hormone effects, “The human growth hormone is comprised of 191 amino acids. In a study of 21 healthy men aged 61 to 81 years with low IGF-1 levels, six months of HGH treatment resulted in an 8.8 percent increase in lean body mass, a 14.4 percent decrease in adipose-tissue mass, a 1.6 percent increase in average lumbar vertebral bone density, and improvements in skin thickness and overall body composition.”

Other Benefits of Using this HGH Releaser

The exciting thing about Gen20 Plus is that the user gets numerous benefits when the HGH production is increased. Hence, regardless of your gender and age, here’s a thorough rundown of all the advantages you could hope to benefit from when you add GenF20 Plus to your everyday supplement schedule.

• Reduction in wrinkles, dark spots, and other signs of aging

• Better stamina and energy

Improved hair and nail health

• Smoother and better-looking skin

• Increased lean muscle mass and stronger bones

Low cholesterol level and lesser fats

• Improved memory

• Sharpens mind with better concentration power

• Improved sexual performance and increased sex drive

Enhanced mood and better sleep quality

• The better metabolic rate that helps in weight loss

• Improved immune system

GenF20 Plus Side Effects, Safety & Dangers

All of us have read and heard about the countless reviews regarding the miraculous effects of HGH use. However, we are also pretty much aware of the adverse side effects of human growth hormone abuse.

These both are true to a certain degree. Indeed, HGH can provide an excellent deal for your overall wellbeing and younger appearance. Yet, to state that HGH is a phenomenal thing is altogether in the zone of personal perception.

Yes, HGH used to be an unsafe alternative, but that was back when HGH injections shook the universe of the famous and wealthy. These days, there are harmless natural HGH supplement choices in the form of tablets, capsules, and sprays.

Long story short, this supplement has nothing to do with the costly and possibly risky HGH history usually connected with the notorious injections.

May some people ask – is the product FDA approved, and is it safe to use? The short answer is – “The FDA regulates dietary supplements as food, not as drugs.”

Where to Buy Genf20 Plus Booster?

In any case, there’s a catch. Just because you don’t need to stress over the product itself doesn’t imply that you need to let down your guard for good. You need to ensure that you’re getting genuine products rather than products you have never heard about.

Many of them become so popular and successful that the scammers can’t avoid the temptation of exploiting eager clients, who are willing to get them as soon as possible. Fortunately for you, there’s a primary method to maintain a strategic distance from these scammers. All you need to do is order the product from the official GenF20 Plus website.

Everyone is unique, and it is not necessary that what works for one individual might work for the other as well. The same is the case with Genf20 Plus, and however, since it accompanies a 67 days money-back guarantee, you don’t need to stress over letting your cash go to waste. If it works for you, fabulous! However, if it doesn’t work for you, you can get the cashback at that point.

References

1. [Sonawane et al., Dovepress, 2015] – “Effect of GenF20 Plus on serum IGF-1 levels in healthy adults: a randomized controlled study” A 12-week randomized controlled trial showing that GenF20 Plus increased serum IGF-1 levels by 28.57% (adjusted) in subjects ≥40 years of age compared to -0.55% in the placebo group (P<0.05). This was the first clinical study conducted specifically on GenF20 Plus to assess its effects on IGF-1 levels, a marker of human growth hormone activity.
2. [Rudman et al., New England Journal of Medicine, 1990] – “Effects of human growth hormone in men over 60 years old” The landmark study on synthetic HGH demonstrating that 21 healthy men aged 61–81 years receiving six months of biosynthetic human growth hormone experienced an 8.8% increase in lean body mass, 14.4% decrease in adipose tissue mass, 1.6% increase in lumbar vertebral bone density, and improvements in skin thickness and overall body composition without diet or exercise changes.
3. [Yalçintaş et al., PMC, 2024] – “Exploring the impact of colostrum supplementation on muscle development and athletic performance” A comprehensive review demonstrating that bovine colostrum supplementation increases muscle development in athletes through IGF-1-mediated pathways. IGF-1 modulates muscle size and function by altering protein synthesis and degradation, with studies showing significantly greater increases in lean body mass compared to whey protein controls.
4. [Chromiak et al., ScienceDirect, 2002] – “Use of amino acids as growth hormone-releasing agents by athletes” A comprehensive review of amino acid-induced GH secretion mechanisms showing that specific amino acids (arginine, lysine, ornithine) stimulate growth hormone release intravenously or orally. Intravenous arginine administration produced more than 20-fold increase in plasma GH in females and 8.6-fold in males, establishing the scientific basis for amino acid inclusion in HGH releaser supplements.
5. [Latour et al., PMC, 2021] – “Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise: randomized controlled trial” A double-blind study on elite rowers from the Polish Rowing Team demonstrating that Astragalus Membranaceus Root (AMR) supplementation restores immunological balance in strenuously trained athletes. Results showed stabilization of natural killer (NK) and T regulatory (Treg) cells, preventing exercise-induced immunosuppression and upper respiratory tract infections.
6. [Powers et al., PMC, 2008] – “Growth hormone isoform responses to GABA ingestion at rest and after resistance exercise” Clinical research demonstrating that oral administration of GABA (gamma-aminobutyric acid) elevates both resting and post-exercise serum growth hormone concentrations. The study showed that ingested GABA increases both immunoreactive GH (irGH) and immunofunctional GH (ifGH) levels and augments the resistance exercise-induced GH response.
7. [Jo et al., PMC, 2021] – “Effect of Deer Antler Extract on Muscle Differentiation and myogenic gene expression” Research showing that deer antler extract increases expression of myogenic regulatory factors (MyoD1, Myf5, myogenin), inhibits muscle atrophy genes, and promotes muscle cell differentiation. The extract contains high concentrations of IGF-1, IGF-2, and over 390 bioactive compounds supporting muscle growth, bone remodeling, and tissue regeneration.
8. [Hammarqvist et al., PMC, 1992] – “Biosynthetic human growth hormone preserves both muscle protein synthesis and whole-body nitrogen economy” A clinical study demonstrating that synthetic hGH preserves muscle protein synthesis capacity, maintains muscle glutamine levels, and improves whole-body nitrogen balance. The research shows that HGH impedes postoperative decreases in ribosome concentration and prevents the decline in muscle protein synthesis observed in controls.

Research Team

The BoostHormone Research Team is a collective of fitness researchers, nutrition specialists, and health science professionals dedicated to providing evidence-based information about hormone optimization and performance enhancement.

With expertise in sports nutrition, endocrinology, and supplement science, our team analyzes peer-reviewed research and clinical studies to deliver honest, science-backed insights. We cut through industry hype to provide the accurate information you need to make informed decisions about your health and performance.

Our mission: translate complex scientific research into practical, actionable guidance – always prioritizing your safety and long-term wellness. Read Our Editorial Guidelines.

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