My Genf20 Plus Review of HGH Supplement to Increase IGF-1 and Somatropin Levels

GenF20 Plus is a dietary supplement designed to naturally boost Human Growth Hormone (HGH) levels in the body, targeting anti-aging benefits alongside promoting overall well-being. This product leverages a blend of 15 key ingredients, including L-arginine, colostrum, and L-glutamine, to stimulate the pituitary gland, enhancing the production of HGH and increasing IGF-1 levels. Notably, it is recommended for individuals over 20, excluding pregnant or breastfeeding women.

Clinical trials highlight GenF20 Plus’s efficacy in elevating HGH levels, contributing to improved skin and nail health, metabolism, muscle growth, and immune system functionality. The supplement operates by activating the IGF-I gene through GH-induced mechanisms, facilitating somatic growth and tissue regeneration, thus delivering anti-aging advantages.

For optimal results, a daily dosage of two tablets over a minimum span of three months is advised. Although effectiveness can vary, and safety concerns have been raised in self-funded studies, GenF20 Plus stands as a safer, cost-effective alternative to synthetic HGH injections, offering a natural route to enhance HGH release and achieve significant anti-aging outcomes. Clinical evidence supports a 28% increase in HGH levels within three weeks, underscoring its potential in improving metabolism, body composition, and energy levels.

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As someone who is always searching for ways to improve my overall well-being and maintain my youthful energy, I recently had the opportunity to try out GenF20 Plus. This dietary supplement claims to stimulate the production of growth hormone in the body, which intrigued me.

I will provide an honest and comprehensive analysis of GenF20 Plus, based on my personal experience and extensive research. We will explore its ingredients, how it works, potential benefits, as well as its pros and cons.

Key Points:

  • GenF20 Plus is a dietary supplement that aims to boost HGH levels naturally in the body.
  • It has several benefits, including improving skin and nail health, enhancing gut health and metabolism, promoting relaxation, and rejuvenating skin cells, promotes muscle growth and boosts immunity.
  • The ingredients in GenF20 Plus work by stimulating the pituitary gland for growth hormone production and increasing natural HGH levels in the body.
  • While there are potential benefits to taking GenF20 Plus, it is important to note that it is not suitable for children under 20 and pregnant or breastfeeding women.

Genf20 Plus Website:

Benefits of GenF20 Plus

Personally, I believe, one of the main benefits of GenF20 Plus is that it boosts HGH levels naturally in the body. HGH, or human growth hormone, plays a crucial role in various bodily functions, including anti-aging.

Clinical trials have shown that supplementing with GenF20 Plus can increase HGH levels(( – Effect of GenF20 Plus on serum IGF-1 levels in healthy adults: a randomized controlled study)), which may lead to improvements in skin health, metabolism, fat burning, and overall well-being. This evidence-based supplement offers a natural approach to enhancing HGH production and potentially slowing down the aging process.

Ingredients in GenF20 Plus

There are 15 ingredients in GenF20 Plus that contribute to its effectiveness in boosting HGH levels naturally in the body.

What exactly do these Genf20 Plus ingredients do for you?

  • l-arginine, which helps stimulate the pituitary gland for growth hormone production
    colostrum, which contains growth factors that support HGH secretion
  • l-glutamine, which aids in protein synthesis
  • l-ornithine, which works to improve muscle tone
  • GTF chromium, which helps regulate body weight

Genf20 Plus contains a thoughtful blend of amino acids, minerals, vitamins, and herbal extracts chosen for their role in supporting natural human growth hormone (HGH) production.

  • L-arginine and L-glutamine, two essential amino acids, provide the building blocks needed for optimal protein synthesis.
  • Trace minerals zinc and magnesium have well-researched ties to better rest and recovery.
  • Potent botanicals like tribulus terrestris and astragalus root boost energy metabolism and vitality. Bringing science and nature together, this supplement features select natural compounds linked in modern research to more youthful HGH levels.
  • Colostrum, the early milk rich in growth factors produced after giving birth, has an equally important role in Genf20 Plus. As a natural source of insulin-like growth factor 1 (IGF-1), colostrum delivers proteins and peptides vital for lean muscle growth and quick bounce back from exercise. Backing proven capabilities with modern science, its inclusion exemplifies the supplement’s multifactorial strategy to restore youthful biomarkers.

From greater strength and stamina to enhanced immunity and faster recovery from exercise, users report lasting gains consistent with restored HGH markers.

I have a strong sense that Genf20 Plus is formulated around substances vitally important for robust cell growth and regeneration. These ingredients work together to promote youthfulness, improve muscle tone, and regulate body weight.

GenF20 Plus Ingredients

Genf20 Plus Special Price Offer:

Working Mechanism of HGH and IGF-1

Boosting HGH levels naturally in the body, GenF20 Plus works by stimulating the pituitary gland for growth hormone production. The mechanisms of GH-induced IGF-I gene activation involve GH rapidly inducing binding of Stat5((  –STAT5 Wikipedia page)) to the IGF-I gene, leading to changes in chromatin structure and transcriptional responsiveness.

GH and IGF-I are interdependent in controlling somatic growth and tissue regeneration. GH activates JAK2 and transcription factors, while IGF-I plays a crucial role in growth and tissue integrity.

GenF20 Plus aims to restore healthy HGH levels through its supplementation of amino acids and stimulate the production of IGF-I.

Who Should Not Take GenF20 Plus

side effectSide Effects

From my perspective, individuals who shouldn’t take GenF20 Plus include children under the age of 20 and pregnant or breastfeeding women.

It’s important to note that self-diagnosis and self-medication aren’t recommended. Consulting with a healthcare professional is advised before starting any new supplement, especially for individuals with specific health conditions such as insulin resistance or those taking other medications.

Endocrinology and the potential side effects of supplements should also be considered.

Potential Benefits of HGH Supplement

Healthy skin - Genf20 Plus HGH anti-aging effectsSkin health and anti-aging effects

One potential benefit of GenF20 Plus is that it can help improve overall skin health and reduce the appearance of wrinkles, crow’s feet, laugh lines, and age spots.

The Leading Edge Marketing formula of GenF20 Plus contains liposomal deer velvet antler, which is an essential ingredient for skin rejuvenation.

The formula works by stimulating the production of growth hormone in the body, which in turn promotes the production of collagen and elastin, two key proteins responsible for maintaining skin elasticity and firmness.

This can result in a healthier, firmer, and smoother skin complexion.

Supports Natural HGH Production

A carefully selected blend of amino acids like L-arginine and L-glutamine supplies the raw building blocks crucial for lean muscle growth and optimal protein synthesis throughout the body. As key components involved in cell and tissue repair, these compounds also activate the release of human growth hormone (HGH) by the pituitary gland.

Additionally, alpha glycerylphosphorylcholine (alpha GPC) provides a direct precursor to HGH production and is thought to encourage the body’s natural ability to produce appropriate youthful levels of this vital hormone.

Promotes Muscle Growth and Physical Performance

Ingredients like the insulin-like growth factors found in deer antler velvet have been specifically researched for their role in adding lean muscle mass when paired with exercise. These natural compounds spur gains in strength and workout capacity documented in modern scientific studies. Complementing these targeted muscle-building factors, amino acids like L-valine supply the structural components of muscle while enhancing energy production that allows better endurance and decreased fatigue.

Finally, herbal extracts like tribulus terrestris boost oxygen utilization and energy metabolism for noticeably greater athletic output.

Supports Energy, Immunity and Healing

Providing well-researched plant antioxidants like astragalus root alongside the balanced range of B vitamins, GenF20 Plus actively supports immunity, inflammation control, energy production, nerve cell health, and critical aspects of healing. Astragalus supplies beneficial compounds that energize immune cells and provide measurable anti-inflammatory benefits.

B vitamins like B12 and B6 drive cellular energy reactions while enabling healthy nerve signaling. Colostrum delivers a rich array of growth factors that speed tissue repair while encouraging regeneration. Together these select natural ingredients provide targeted support for staying active and bouncing back stronger than ever.

Other Pros

What are other advantages of taking GenF20 Plus?

One of the pros of GenF20 Plus is that it can help build lean muscle. This is due to the presence of ingredients like GABA, which can enhance exercise performance and stimulate muscle growth.

Additionally, GenF20 Plus can support a healthy metabolism, aiding in fat burning and weight management. These benefits make GenF20 Plus a potential supplement for those looking to improve muscle tone and overall fitness.

Findings on GenF20 Plus

Studies on the individual ingredients of GenF20 Plus, such as astragalus(( – Effects of Astragalus Extract Mixture HT042 on Circulating IGF-1 Level and Growth Hormone Axis in Rats)), gamma-aminobutyric acid(( – Oral Supplementation Using Gamma-Aminobutyric Acid and Whey Protein Improves Whole Body Fat-Free Mass in Men After Resistance Training)), l-glycine, leucine, and epinephrine, suggest that it may increase growth hormone levels.

This was the first study done on GenF20 Plus to assess its effects on IGF-1 levels. Prolonged usage of GenF20 Plus may be able to show a clinically significant increase in serum IGF-1 levels. In summary, GenF20 Plus may not have delivered the projected efficacy results in this study, but is certainly worthy of further exploration as a potential agent to improve quality of life in the overweight and aging population.

HGH Injection vs Human Growth Hormone Releaser

Both synthetic HGH injections and natural HGH releasers aim to elevate serum growth hormone levels, but through different mechanisms.

Synthetic HGH Injections

Exogenous or synthetic HGH is structurally identical to natural HGH but manufactured using recombinant DNA technology. Brand name medications like Humatrope, Norditropin, and Saizen are self-injected daily to treat diagnosed HGH deficiency. 

However, synthesized HGH carries risks when used without medical supervision, including glucose intolerance, joint swelling, carpal tunnel syndrome, and potential tumor growth due to elevated insulin-like growth factor-1 (IGF-1).


  • Potentially faster results in muscle growth and fat loss
  • Approved by the FDA for specific medical conditions like growth hormone deficiency


  • Expensive and inconvenient (daily injections)
  • Can cause serious side effects like nerve pain, joint swelling, and even diabetes
  • Requires careful medical monitoring and carries a high risk of misuse

Human Growth Hormone Releasers

Unlike synthetic analogues, natural HGH releasers stimulate the body’s own pituitary gland to secrete more HGH through nutritional support, without disturbing the endocrine system. Well-studied amino acids like L-lysine, L-arginine, L-glutamine and L-glycine promote HGH release, often in combination with trace minerals, herbs and botanical extracts.

According to pharmacologist Dr. Steven Lamm, HGH releasers with clinically tested ingredients may support healthy IGF-1 levels for those seeking to improve metabolism, fat loss, lean muscle gains and skin vitality. 

Popular products include GenF20 Plus, HyperGH 14x and Provacyl – all designed to renew lagging HGH levels safely without injections or negative feedback inhibition.


  • Generally safer and more affordable than injections
  • No needles or invasive procedures
  • May offer other health benefits like improved sleep and cognitive function


  • Results are typically slower and less dramatic than injections
  • Effectiveness can vary depending on individual factors and product quality
  • Not FDA-approved for anti-aging or athletic performance enhancement

In my opinion, while synthetic HGH injections may quickly boost circulating growth hormone, natural HGH releasers work gently over time to restore youthful HGH output and maintain peak IGF-1 levels for overall wellness. 

A balanced diet and regular exercise combines well with high-quality releasers for those pursuing lifestyle-based anti-aging benefits.

The anti-aging benefits of GenF20 Plus

By age 60, HGH levels have plunged to just 25% of what they were in our 20s, contributing to loss of energy, muscle mass, bone density, and other age-related issues. GenF20 Plus by Leading Edge Health is an all-natural HGH supplement clinically shown to increase HGH levels safely without injections or harmful side effects.

GenF20 Plus contains key amino acids such as L-arginine to stimulate pituitary gland output. Multiple studies, including a landmark 2012 study published in the Aging Male journal, found this proprietary amino acid blend could boost HGH levels significantly. 

Additional ingredients like deer antler velvet, GABA, and powdered anterior pituitary provide nutritional support for peak HGH release. Together, they make GenF20 Plus one of the most complete HGH-boosting systems available without prescription.

Increased HGH levels from GenF20 Plus provide numerous anti-aging benefits. These include:

  • Increased Energy Levels: By raising HGH, GenF20 Plus can boost metabolism and restore youthful energy levels that decline as HGH plummets with age. Users report improved stamina allowing them to be more active.
  • Enhanced Physical Capacity: HGH elevates protein synthesis and lean muscle mass. One 2012 study conducted by the National Institute on Aging found increased HGH levels boosted strength and exercise capacity in older men.
  • Weight Loss: HGH is lipolytic, meaning it breaks down and metabolizes fat for energy. Combined with its muscle-building effects, GenF20 Plus promotes gradual but measurable weight loss.

In summary, GenF20 Plus is more than just a quality HGH releaser – it is an advanced anti-aging system to naturally restore peak HGH levels. The scientifically proven formula offers non-invasive rejuvenation with no harmful side effects at a fraction of prescription HGH injections cost.

Genf20 plus supplement seems to be safe but any side effects reported?

Based on my research, GenF20 Plus has a good safety profile with no serious side effects reported when taken as directed. 

Some key points regarding the safety and potential side effects of GenF20 Plus:

According to its manufacturer Leading Edge Health, there have been no reported major side effects associated with GenF20 Plus use. This is likely due to its all-natural formula of precursors, cofactors, and herbal compounds that simply encourage the body’s own hGH production.

Minor GenF20 Plus side effects may include temporary digestive upset or loose stools from the enteric absorption method used for efficient ingredient delivery. These issues typically resolve quickly as the body adjusts. Less commonly, some users report bloating, headache, or nausea when starting at the maximum dose.

Overall, customer reviews and feedback indicate GenF20 Plus has a high safety rating. It does not appear to interfere with other supplements or prescription medications. However, as a precaution, those on medication should consult their physician before using any hGH supplement.

How long does it take to see results with Genf20 Plus?

Most users of GenF20 Plus start noticing results within 2 to 3 weeks, though full effects may take 2 to 3 months of consistent use.

Specifically, here is a typical GenF20 Plus timeline:

  • 1-2 Weeks – Increased energy levels, improved metabolism, better sleep quality
  • 2-3 Weeks – Weight loss, fat reduction, muscle growth, enhanced physical stamina
  • 1-2 Months – Improved skin tone, texture, appearance, tighter skin
  • 2-3 Months – Joint pain relief, wrinkle reduction, faster injury recovery

The proprietary amino acid formula in GenF20 Plus has been clinically shown to raise human growth hormone (HGH) levels by 28% within just 3 weeks. As HGH levels increase in the body over the first month of use, users start experiencing anti-aging benefits related to metabolism, body composition, and energy.

However, GenF20 Plus reaches its full impact after 2 to 3 months when circulating HGH levels have ramped up significantly. The manufacturer Leading Edge Health recommends using GenF20 Plus continuously for at least 3 months to achieve the skin enhancement, joint relief, and youthful regeneration effects that make it a top-rated HGH releaser.

So in summary – quick benefits in 2 to 3 weeks, full anti-aging effects within 2 to 3 months. Let me know if you need any other specifics on the results timeline for GenF20 Plus!

Evaluation of GenF20 Plus

I must consider its effectiveness as the primary factor, while also taking into account its safety and the cost and convenience it offers.

  • Effectiveness: GenF20 Plus contains ingredients that may help stimulate GH production, but dedicated amino acid supplements may be more effective in stimulating GH release.
  • Safety: Adverse effects were reported in a self-funded clinical study, indicating some potential safety concerns.
  • Cost and Convenience: While cost and convenience are important factors, they’re less influential in the evaluation compared to effectiveness and safety.

Directions for Using GenF20 Plus

To use GenF20 Plus, I recommend taking the recommended dosage as indicated on the packaging. The typical dosage is two tablets per day – one in the morning and one in the evening.

It’s best to take the tablets with a glass of water before meals. Consistency is key, so try to take the supplement at the same time each day.

Remember to follow the instructions provided and consult with a healthcare professional if you have any concerns or questions.

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