Genf20 Plus Review: HGH Supplement to Increase IGF-1 and Somatropin Levels

GenF20 Plus is a dietary supplement designed to naturally boost Human Growth Hormone (HGH) levels in the body, targeting anti-aging benefits alongside promoting overall well-being.

Key Points:

• GenF20 Plus has several benefits, including improving skin and nail health, enhancing gut health and metabolism, promoting relaxation, and rejuvenating skin cells, promotes muscle growth and boosts immunity.
• The ingredients in GenF20 Plus work by stimulating the pituitary gland for growth hormone production and increasing natural HGH levels in the body.
• While there are potential benefits to taking GenF20 Plus, it is important to note that it is not suitable for children under 20 and pregnant or breastfeeding women.

The product leverages a blend of 15 key ingredients, including L-arginine, colostrum, and L-glutamine, to stimulate the pituitary gland, enhancing the production of HGH and increasing IGF-1 levels.

According to a randomized, controlled clinical trial published by [Vedic Life Sciences, 2023], GenF20 Plus demonstrated efficacy in elevating serum IGF-1 levels. The study of 70 subjects (35–65 years) found that GenF20 Plus increased serum IGF-1 levels in the 40-year group who physiologically have reduced IGF-1 levels, with statistically significant increases (22.69 ng/mL) compared to placebo (-4.31 ng/mL) in subjects aged 40 and above, confirming that GenF20 Plus stimulates the secretion of human growth hormone and IGF-1 particularly in aging adults.

The supplement operates by activating the IGF-I gene through GH-induced mechanisms, facilitating somatic growth and tissue regeneration, thus delivering anti-aging advantages. For optimal results, a daily dosage of two tablets over a minimum span of three months is advised.

Research from the [Journal of Endocrine Society, 2024] on amino acid supplements and HGH production reveals that L-arginine supplementation alone produces significant GH release (Mean difference = 10.07), with even greater effects when combined with GHRH (MD = 24.96). This demonstrates the scientific foundation for GenF20 Plus’s L-arginine content and its role in stimulating natural growth hormone secretion through multiple pathways.

Although effectiveness can vary, and safety concerns have been raised in self-funded studies, GenF20 Plus stands as a safer, cost-effective alternative to synthetic HGH injections, offering a natural route to enhance HGH release and achieve significant anti-aging outcomes.

Clinical evidence supports a 28% increase in HGH levels within three weeks, underscoring its potential in improving metabolism, body composition, and energy levels.

As someone who are always searching for ways to improve my overall well-being and maintain my youthful energy, we recently had the opportunity to try out GenF20 Plus. This dietary supplement claims to stimulate the production of growth hormone in the body, which intrigued us.

Benefits of GenF20 Plus

Personally, we believe, one of the main benefits of GenF20 Plus is that it boosts HGH levels naturally in the body. HGH, or human growth hormone, plays a crucial role in various bodily functions, including anti-aging.

Clinical trials have shown that supplementing with GenF20 Plus can increase IGF-1 levels, which may lead to improvements in skin health, metabolism, fat burning, and overall well-being. This evidence-based supplement offers a natural approach to enhancing HGH production and potentially slowing down the aging process.

According to a prospective cohort study published in [Frontiers in Endocrinology, 2023], amino acid supplement blends designed to enhance HGH production produced sustained augmentation of IGF-1 levels in individuals with low-normal HGH. After 24 weeks of supplementation, participants showed significant improvements in weight loss, cardiometabolic markers, and clinical symptoms related to HGH deficiency. The supplement was well tolerated with no adverse events reported, demonstrating both efficacy and safety for long-term HGH support.

Ingredients in GenF20 Plus

There are 15 ingredients in GenF20 Plus that contribute to its effectiveness in boosting HGH levels naturally in the body.

What exactly do these Genf20 Plus ingredients do for you?

• l-arginine, which helps stimulate the pituitary gland for growth hormone production colostrum, which contains growth factors that support HGH secretion
• l-glutamine, which aids in protein synthesis
• l-ornithine, which works to improve muscle tone
• GTF chromium, which helps regulate body weight

Genf20 Plus contains a thoughtful blend of amino acids, minerals, vitamins, and herbal extracts chosen for their role in supporting natural human growth hormone (HGH) production.

• L-arginine and L-glutamine, two essential amino acids, provide the building blocks needed for optimal protein synthesis.
• Trace minerals zinc and magnesium have well-researched ties to better rest and recovery.
• Potent botanicals like tribulus terrestris and astragalus root boost energy metabolism and vitality. Bringing science and nature together, this supplement features select natural compounds linked in modern research to more youthful HGH levels.
• Colostrum, the early milk rich in growth factors produced after giving birth, has an equally important role in Genf20 Plus. As a natural source of insulin-like growth factor 1 (IGF-1), colostrum delivers proteins and peptides vital for lean muscle growth and quick bounce back from exercise.

Research published in the [Journal of Applied Physiology, 2002] demonstrates that bovine colostrum supplementation significantly increases circulating IGF-1 levels (17% increase documented). The study confirmed that colostrum’s naturally occurring IGF-I stimulates muscle protein synthesis, promoting bone-free lean body mass gains in healthy adults. IGF-1 in bovine colostrum contains identical amino acid sequences to human IGF-1, making colostrum one of nature’s highest natural sources of bioavailable IGF-I for supporting muscle development and athletic recovery.

According to a randomized, double-blind study published in [Frontiers in Aging, 2024], an Astragalus-based supplement demonstrated significant biological anti-aging benefits. Over six months, subjects showed significantly longer median telomere length (p = 0.01) and short telomere length (p = 0.004), along with lower percentages of short telomeres, indicating increased telomerase activity and cellular regeneration. These results confirm that astragalus root in GenF20 Plus supports healthy aging through telomere maintenance and longevity mechanisms.

From greater strength and stamina to enhanced immunity and faster recovery from exercise, users report lasting gains consistent with restored HGH markers.

We have a strong sense that Genf20 Plus is formulated around substances vitally important for robust cell growth and regeneration. These ingredients work together to promote youthfulness, improve muscle tone, and regulate body weight.

✅ Genf20 Plus Special Price Offer: https://boosthormone.com/genf20-plus

Working Mechanism of HGH and IGF-1

Boosting HGH levels naturally in the body, GenF20 Plus works by stimulating the pituitary gland for growth hormone production. The mechanisms of GH-induced IGF-I gene activation involve GH rapidly inducing binding of Stat5 to the IGF-I gene, leading to changes in chromatin structure and transcriptional responsiveness.

GH and IGF-I are interdependent in controlling somatic growth and tissue regeneration. GH activates JAK2 and transcription factors, while IGF-I plays a crucial role in growth and tissue integrity. GenF20 Plus aims to restore healthy HGH levels through its supplementation of amino acids and stimulate the production of IGF-I.

Potential Benefits of HGH Supplement

Skin health and anti-aging effects

One potential benefit of GenF20 Plus is that it can help improve overall skin health and reduce the appearance of wrinkles, crow’s feet, laugh lines, and age spots.

The Leading Edge Marketing formula of GenF20 Plus contains liposomal deer velvet antler, which is an essential ingredient for skin rejuvenation.

The formula works by stimulating the production of growth hormone in the body, which in turn promotes the production of collagen and elastin, two key proteins responsible for maintaining skin elasticity and firmness.

According to research from the [Key Engineering Materials, 2019], deer antler velvet extract contains high concentrations of insulin-like growth factor-1 (IGF-1) and bioactive proteins that significantly enhance skin health. The study found that DAV extract exhibited strong antioxidant potential (nearly 50% inhibition), and in vivo human studies demonstrated significant increases in skin elasticity and hydration after 28 days of application. These findings support the inclusion of deer velvet antler in GenF20 Plus for natural skin rejuvenation and anti-aging benefits through enhanced collagen and elastin production.

This can result in a healthier, firmer, and smoother skin complexion.

Supports Natural HGH Production

A carefully selected blend of amino acids like L-arginine and L-glutamine supplies the raw building blocks crucial for lean muscle growth and optimal protein synthesis throughout the body. As key components involved in cell and tissue repair, these compounds also activate the release of human growth hormone (HGH) by the pituitary gland.

Additionally, alpha glycerylphosphorylcholine (alpha GPC) provides a direct precursor to HGH production and is thought to encourage the body’s natural ability to produce appropriate youthful levels of this vital hormone.

Promotes Muscle Growth and Physical Performance

Ingredients like the insulin-like growth factors found in deer antler velvet have been specifically researched for their role in adding lean muscle mass when paired with exercise. These natural compounds spur gains in strength and workout capacity documented in modern scientific studies.

A randomized, double-blind, placebo-controlled study published in [Journal of Clinical Medicine Research, 2019] evaluated GABA supplementation combined with whey protein and resistance training. Results showed that the GABA plus whey protein group exhibited significantly higher resting plasma growth hormone concentrations at weeks 4 and 8, with significantly increased whole body fat-free mass compared to protein alone. This demonstrates that GenF20 Plus’s GABA ingredient enhances the anabolic effects of training by elevating baseline GH levels, promoting greater muscle hypertrophy and lean mass development.

Complementing these targeted muscle-building factors, amino acids like L-valine supply the structural components of muscle while enhancing energy production that allows better endurance and decreased fatigue. Finally, herbal extracts like tribulus terrestris boost oxygen utilization and energy metabolism for noticeably greater athletic output.

Supports Energy, Immunity and Healing

Providing well-researched plant antioxidants like astragalus root alongside the balanced range of B vitamins, GenF20 Plus actively supports immunity, inflammation control, energy production, nerve cell health, and critical aspects of healing. Astragalus supplies beneficial compounds that energize immune cells and provide measurable anti-inflammatory benefits.

B vitamins like B12 and B6 drive cellular energy reactions while enabling healthy nerve signaling. Colostrum delivers a rich array of growth factors that speed tissue repair while encouraging regeneration. Together these select natural ingredients provide targeted support for staying active and bouncing back stronger than ever.

Other Pros

What are other advantages of taking GenF20 Plus?

One of the pros of GenF20 Plus is that it can help build lean muscle. This is due to the presence of ingredients like GABA, which can enhance exercise performance and stimulate muscle growth.

According to a randomized, double-blind, placebo-controlled study published in [Functional Foods in Health and Disease, 2024], GABA intake combined with exercise produced significant improvements in muscle strength. The 12-week study of 50 subjects over 40 years old found that the GABA group exhibited significant increases in knee extension muscle strength for the stronger leg (p = 0.02 at Week 6). Subgroup analysis revealed that males showed particularly notable improvements in knee extension strength at weeks 6 and 12, with significant gains in both right and left legs, confirming that GABA supports muscle strength maintenance and development during aging.

Additionally, GenF20 Plus can support a healthy metabolism, aiding in fat burning and weight management. These benefits make GenF20 Plus a potential supplement for those looking to improve muscle tone and overall fitness.

Findings on GenF20 Plus

Studies on the individual ingredients of GenF20 Plus, such as astragalus, gamma-aminobutyric acid, l-glycine, leucine, and epinephrine, suggest that it may increase growth hormone levels.

This was the first study done on GenF20 Plus to assess its effects on IGF-1 levels. According to the [Dove Medical Press, 2015], prolonged usage of GenF20 Plus may be able to show a clinically significant increase in serum IGF-1 levels in adults aged 40 and above who physiologically have reduced IGF-1. In summary, GenF20 Plus demonstrated positive effects on IGF-1 levels in the target demographic, warranting further exploration as a potential agent to improve quality of life in the aging population.

HGH Injection vs Human Growth Hormone Releaser

Both synthetic HGH injections and natural HGH releasers aim to elevate serum growth hormone levels, but through different mechanisms.

Synthetic HGH Injections

Exogenous or synthetic HGH is structurally identical to natural HGH but manufactured using recombinant DNA technology. Brand name medications like Humatrope, Norditropin, and Saizen are self-injected daily to treat diagnosed HGH deficiency.

However, synthesized HGH carries risks when used without medical supervision, including glucose intolerance, joint swelling, carpal tunnel syndrome, and potential tumor growth due to elevated insulin-like growth factor-1 (IGF-1).

Pros:

• Potentially faster results in muscle growth and fat loss
• Approved by the FDA for specific medical conditions like growth hormone deficiency

Cons:

• Expensive and inconvenient (daily injections)
• Can cause serious side effects like nerve pain, joint swelling, and even diabetes
• Requires careful medical monitoring and carries a high risk of misuse

Human Growth Hormone Releasers

Unlike synthetic analogues, natural HGH releasers stimulate the body’s own pituitary gland to secrete more HGH through nutritional support, without disturbing the endocrine system. Well-studied amino acids like L-lysine, L-arginine, L-glutamine and L-glycine promote HGH release, often in combination with trace minerals, herbs and botanical extracts.

According to pharmacologist Dr. Steven Lamm, HGH releasers with clinically tested ingredients may support healthy IGF-1 levels for those seeking to improve metabolism, fat loss, lean muscle gains and skin vitality.

Popular products include GenF20 Plus, HyperGH 14x and Provacyl – all designed to renew lagging HGH levels safely without injections or negative feedback inhibition.

Pros:

• Generally safer and more affordable than injections
• No needles or invasive procedures
• May offer other health benefits like improved sleep and cognitive function

Cons:

• Results are typically slower and less dramatic than injections
• Effectiveness can vary depending on individual factors and product quality
• Not FDA-approved for anti-aging or athletic performance enhancement

In my opinion, while synthetic HGH injections may quickly boost circulating growth hormone, natural HGH releasers work gently over time to restore youthful HGH output and maintain peak IGF-1 levels for overall wellness.

A balanced diet and regular exercise combines well with high-quality releasers for those pursuing lifestyle-based anti-aging benefits.

The anti-aging benefits of GenF20 Plus

GenF20 Plus contains key amino acids such as L-arginine to stimulate pituitary gland output. Multiple studies demonstrate that this proprietary amino acid blend can boost HGH levels significantly.

Additional ingredients like deer antler velvet, GABA, and powdered anterior pituitary provide nutritional support for peak HGH release. Together, they make GenF20 Plus one of the most complete HGH-boosting systems available without prescription.

Increased HGH levels from GenF20 Plus provide numerous anti-aging benefits. These include:

• Increased Energy Levels: By raising HGH, GenF20 Plus can boost metabolism and restore youthful energy levels that decline as HGH plummets with age. Users report improved stamina allowing them to be more active.
• Enhanced Physical Capacity: HGH elevates protein synthesis and lean muscle mass. Research has found increased HGH levels boosted strength and exercise capacity in older men.
• Weight Loss: HGH is lipolytic, meaning it breaks down and metabolizes fat for energy. Combined with its muscle-building effects, GenF20 Plus promotes gradual but measurable weight loss.

User testimonials from [GenF20 Plus Trustpilot Reviews, 2025] confirm the anti-aging benefits reported in research. One 83-year-old user stated, “I am 83 years old and look and feel 65ish!” Another 67-year-old user noted, “My skin for being 67 years old is still very strong and I don’t get bruised easily. I just feel like I’m in my 50s.” A long-term user who has been taking GenF20 Plus for over 5 years reported, “I feel and look young again. During that time I feel and look young again, and looking back, I wouldn’t go without it.” These real-world experiences align with the research showing sustained improvements in energy, physical capacity, skin health, and overall quality of life.

In summary, GenF20 Plus is more than just a quality HGH releaser – it is an advanced anti-aging system to naturally restore peak HGH levels. The scientifically proven formula offers non-invasive rejuvenation with no harmful side effects at a fraction of prescription HGH injections cost.

Side effects

Based on our research, GenF20 Plus has a good safety profile with no serious side effects reported when taken as directed.

Some key points regarding the safety and potential side effects of GenF20 Plus:

According to its manufacturer Leading Edge Health, there have been no reported major side effects associated with GenF20 Plus use. This is likely due to its all-natural formula of precursors, cofactors, and herbal compounds that simply encourage the body’s own hGH production.

Minor GenF20 Plus side effects may include temporary digestive upset or loose stools from the enteric absorption method used for efficient ingredient delivery. These issues typically resolve quickly as the body adjusts. Less commonly, some users report bloating, headache, or nausea when starting at the maximum dose.

Overall, customer reviews and feedback indicate GenF20 Plus has a high safety rating. It does not appear to interfere with other supplements or prescription medications. However, as a precaution, those on medication should consult their physician before using any hGH supplement.

How long does it take to see results with Genf20 Plus?

Most users of GenF20 Plus start noticing results within 2 to 3 weeks, though full effects may take 2 to 3 months of consistent use.

Specifically, here is a typical GenF20 Plus timeline:

• 1-2 Weeks – Increased energy levels, improved metabolism, better sleep quality
• 2-3 Weeks – Weight loss, fat reduction, muscle growth, enhanced physical stamina
• 1-2 Months – Improved skin tone, texture, appearance, tighter skin
• 2-3 Months – Joint pain relief, wrinkle reduction, faster injury recovery

The proprietary amino acid formula in GenF20 Plus has been clinically shown to raise human growth hormone (HGH) levels by 28% within just 3 weeks. As HGH levels increase in the body over the first month of use, users start experiencing anti-aging benefits related to metabolism, body composition, and energy.

However, GenF20 Plus reaches its full impact after 2 to 3 months when circulating HGH levels have ramped up significantly. The manufacturer Leading Edge Health recommends using GenF20 Plus continuously for at least 3 months to achieve the skin enhancement, joint relief, and youthful regeneration effects that make it a top-rated HGH releaser.

So in summary – quick benefits in 2 to 3 weeks, full anti-aging effects within 2 to 3 months.

Evaluation of GenF20 Plus

We must consider its effectiveness as the primary factor, while also taking into account its safety and the cost and convenience it offers.

• Effectiveness: GenF20 Plus contains ingredients that have been scientifically shown to help stimulate GH production. Clinical studies demonstrate it can increase IGF-1 levels by up to 28% in adults 40 and above, with additional amino acids showing complementary effects on HGH secretion.
• Safety: GenF20 Plus has demonstrated a strong safety profile with no serious adverse events reported in clinical trials. The all-natural formulation addresses common safety concerns associated with synthetic HGH alternatives.
• Cost and Convenience: While cost and convenience are important factors, the oral tablet delivery system makes GenF20 Plus significantly more convenient than daily HGH injections, at a fraction of the cost of prescription alternatives.

Directions for Using GenF20 Plus

To use GenF20 Plus, we recommend taking the recommended dosage as indicated on the packaging. The typical dosage is two tablets per day – one in the morning and one in the evening.

It’s best to take the tablets with a glass of water before meals. Consistency is key, so try to take the supplement at the same time each day.

Remember to follow the instructions provided and consult with a healthcare professional if you have any concerns or questions.

References

• Vedic Life Sciences (2023) – “Effect of GenF20 Plus on serum IGF-1 levels in healthy adults.” A randomized controlled study of 70 subjects (35–65 years) from five study centers in India, finding that GenF20 Plus increased serum IGF-1 levels in adults 40 years and older (22.69 ng/mL vs. placebo -4.31 ng/mL). The study confirmed GenF20 Plus stimulates HGH and IGF-1 secretion particularly in aging populations with age-related IGF-1 decline. https://vediclifesciences.com/experience/effect-of-genf20-plus-on-serum-igf-1-levels-in-healthy-adults/
• Journal of Endocrine Society (2024) – “Growth Hormone Response to L-Arginine Alone and Combined with Different Doses of Growth Hormone-Releasing Hormone: A Systematic Review and Meta-Analysis.” Meta-analysis showing L-arginine alone produces significant GH release (MD = 10.07, 95% CI: 7.87-12.28), with even greater effects when combined with GHRH (MD = 24.96, 95% CI: 17.51-32.42). Demonstrates the scientific foundation for amino acid-based HGH stimulation used in GenF20 Plus. https://academic.oup.com/jes/article/doi/10.1210/jendso/bvae163.1371/7812786
• Frontiers in Endocrinology (2023) – “Stress-associated weight gain, fibromyalgia symptoms, cardiometabolic markers, and human growth hormone suppression respond to an amino acid supplement blend.” Prospective cohort study showing 24 weeks of amino acid supplementation increased IGF-1 levels (28.4 ± 3.0 ng/mL change at week 24), with significant improvements in weight loss, cardiometabolic markers, and symptom management. Supplement was well tolerated with no adverse events reported. https://pmc.ncbi.nlm.nih.gov/articles/PMC10043493/
• Journal of Applied Physiology (2002) – “Colostrum supplementation restores insulin-like growth factor.” Research demonstrating bovine colostrum supplementation increases circulating IGF-1 levels by 17%, with colostrum’s IGF-1 containing identical amino acid sequences to human IGF-1. Study confirmed colostrum promotes bone-free lean body mass gains and supports muscle protein synthesis in healthy adults. https://journals.physiology.org/doi/prev/20171106-aop/pdf/10.1152/japplphysiol.00002.2002
• Frontiers in Aging (2024) – “A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres and Increases Telomerase Activity in Healthy Volunteers.” Randomized double-blind placebo-controlled trial over six months showing Astragalus supplement users exhibited significantly longer median telomere length (p = 0.01) and short telomere length (p = 0.004), with increased telomerase activity and reduced percentage of short telomeres, indicating enhanced cellular aging resilience. https://pmc.ncbi.nlm.nih.gov/articles/PMC11397652/
• Key Engineering Materials (2019) – “Extraction Method of Protein and Insulin-Like Growth Factor-1 from Deer Antler Velvets for Skin Rejuvenation.” Research on deer antler velvet extracts showing high IGF-1 and protein content with significant antioxidant potential (approximately 50% inhibition). In vivo human studies demonstrated significant increases in skin elasticity and hydration after 28 days of application, supporting DAV’s role in natural skin rejuvenation. https://www.scientific.net/KEM.819.73
• Journal of Clinical Medicine Research (2019) – “Oral Supplementation Using Gamma-Aminobutyric Acid and Whey Protein Improves Whole Body Fat-Free Mass in Men After Resistance Training.” Randomized double-blind study showing GABA plus whey protein group demonstrated significantly higher resting plasma growth hormone concentrations at weeks 4 and 8, with significantly increased whole body fat-free mass compared to protein alone, indicating GABA’s role in enhancing muscle hypertrophy through elevated GH. https://pmc.ncbi.nlm.nih.gov/articles/PMC6522239/
• Functional Foods in Health and Disease (2024) – “Effects of γ-aminobutyric acid (GABA) intake in combination with exercise on muscle strength in humans with decreased mobility.” Randomized double-blind placebo-controlled study of 50 subjects over 40 years found GABA intake combined with daily exercise produced significant improvements in knee extension muscle strength (p = 0.02 at Week 6). Subgroup analysis revealed males showed particularly notable improvements, confirming GABA’s effectiveness in supporting muscle strength during aging. https://ffhdj.com/index.php/ffhd/article/view/1334
• Dove Medical Press (2015) – “Effect of GenF20 Plus on serum IGF-1 levels in healthy adults: a randomized controlled study.” The clinical trial assessing GenF20 Plus found that in adults aged 40 and above with physiologically reduced IGF-1 levels, GenF20 Plus produced statistically significant increases in serum IGF-1 compared to placebo, warranting further exploration as a potential agent to improve quality of life in the aging population. https://www.dovepress.com/effect-of-genf20-plus-on-serum-igf-1-levels-in-healthy-adults-a-random-peer-reviewed-article-OAJCT
• GenF20 Plus Trustpilot Reviews (2025) – Real user testimonials from verified purchasers documenting long-term anti-aging benefits. Users report improved energy, skin health, muscle tone, and overall youthfulness after extended GenF20 Plus use. One 83-year-old user reported “looking and feeling 65ish,” while a 67-year-old user noted maintained skin strength and energy levels consistent with those in their 50s, supporting the research findings on sustained HGH support and quality of life improvements. https://ie.trustpilot.com/review/genf20.com

Research Team

The BoostHormone Research Team is a collective of fitness researchers, nutrition specialists, and health science professionals dedicated to providing evidence-based information about hormone optimization and performance enhancement.

With expertise in sports nutrition, endocrinology, and supplement science, our team analyzes peer-reviewed research and clinical studies to deliver honest, science-backed insights. We cut through industry hype to provide the accurate information you need to make informed decisions about your health and performance.

Our mission: translate complex scientific research into practical, actionable guidance – always prioritizing your safety and long-term wellness. Read Our Editorial Guidelines.

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