Growth Factor Plus Review – the Solution to Short Stature?

Growth Factor Plus Review: Does It Really Work for Height Increase?

Does Growth Factor Plus really work for increasing height? This review delves into the science behind this supplement—whether it can help address short stature or if it’s merely hype. We’ll break down the ingredients, expert opinions, and real results to see if it’s worth trying.

We have conducted our research on Growth Factor Plus, and it has yielded impressive results for us.

Human growth process

The growth of the body is accelerated during the first period of puberty and concludes when individuals become sexually mature.

Many aspects are involved in the process of human growth and development. The increase of bones via cellular divisions is mainly controlled by somatotropin (human growth hormone).

The anterior pituitary gland releases HGH. Somatotropin is also in charge of the release of Insulin-like growth factor 1 (IGF-1).

According to [Zhao et al., Translational Pediatrics, 2025], research findings demonstrate the efficacy of recombinant human growth hormone (rhGH) treatment in enhancing adult height. The study showed that “rhGH treatment effectively improves the final height SDS and height SDS gain in children with idiopathic growth hormone deficiency (IGHD),” with patients receiving rhGH treatment achieving significantly greater adult height (β=0.41, 95% CI: 0.14, 0.69; P=0.003) compared to those without treatment.

Growth hormone deficiency

Growth hormone deficiency, or GHD, is a health disorder characterized by the inadequate production of growth hormone (GH). Usually, the most visible sign is short stature.

The primary mechanism is typically in pituitary gland disorders. Although the deficiency can also be linked to a lack of other pituitary hormones, it is recognized as a “combined pituitary hormone deficiency”.

According to a [Kim & Yu, Journal of the Endocrine Society, 2025] clinical investigation, growth hormone stimulation tests (GHST) using pharmacologic stimulants including insulin, arginine, glucagon, or L-dopa are used to identify growth hormone deficiency as a cause of short stature. The study involving 59 children found that “GHD was diagnosed when all GH peak levels were below 10 ng/mL during 2 or more GHST,” with 33.9% of short stature patients diagnosed with GHD requiring therapeutic intervention.

Ways to increase height

1) Surgical Method: The surgical method involves surgical intervention in the human body. In such an intervention, the bones of the shins or hips are dissected, after which the operating segment is lengthened with the help of a special device that allows performing longitudinal augmentation of bone tissue by an average of 1 mm per day. The surgical method yields good results in practically any age group. However, it has many disadvantages: the rehabilitation period after the operation is about a year, and there is a risk of various complications.

2) Physiological Method: The physiological method is based on the natural ability of growth zones to increase the longitudinal size of the skeletal bones. The most significant increase occurs when the growth zones of the somatotropic hormone are affected. With the end of puberty, growth zones are inhibited by the testosterone hormone. The physiological method of height increase is based on a complex combination of different effects on growth zones, including special physical exercises (such as hanging on a horizontal bar, stretching, and deflections), a special diet, dietary HGH supplements, and a specific daily regimen.

The physiological method requires more time and is less effective than the surgical method. However, this method is beneficial in that it does not interfere with daily activities, does not lead to dangerous side effects, and encourages people to adopt a healthy lifestyle.

According to [Medical News Today, 2025], “Once the growth plates close, which happens after puberty, there is no way to add height, regardless of what appears on the label of the supplement bottle.” However, certain supplements can strengthen bone and help maintain good posture, with calcium and vitamin D improving bone density and preventing bone loss that can lead to stooped posture.

Growth Factor Plus: The science behind its ingredients

Let’s first analyze the ingredients of Growth Factor Plus to gain a better understanding of its chemistry. Growth Factor Plus pills contain L-Arginine, L-Lysine, L-Glutamine, L-Ornithine, L-Tyrosine, L-Glycine, Colostrum, Phosphatidylcholine complex, Chromium GTF, Soy protein isolate, and Pituitary powder, which make up its main proprietary blend.

It also contains other vital micronutrients, including a wide range of essential amino acids, vitamins, and minerals that are crucial for bone and cell growth, as well as for increasing your HGH levels.

Many of the ingredients above are proven to maintain the concentration of GH levels at the upper limits of the norm. Amino acids can help to accelerate growth as well as physical performance. Since they are a building block of protein, they also promote rapid muscle regeneration and growth.

According to a [Sanmedica International Clinical Trial, 2020] double-blind, randomized, placebo-controlled study, a low-dose amino acid supplement containing L-lysine, L-arginine, oxo-proline, N-acetyl-L-cysteine, L-glutamine, and schizonepeta demonstrated that “at 120 minutes, hGH levels increased by 682% (8-fold) from baseline and were significantly higher than placebo (p=0.01).” The study confirmed that a single dose of the oral amino acid supplement was sufficient to significantly increase hGH levels in healthy adult males and females.

✔️ L-Arginine

Several amino acids are known to have a stimulating effect on the release of growth hormone in the body. Above all, it’s L-Arginine. L-Arginine has probably earned its reputation as a stimulant in the release of GH thanks to longstanding research by scientists, who claimed that intravenous administration of 30 grams always leads to a significant release of growth hormone.

Indeed, this effect was so precisely proven that it was used as a test to verify whether a person’s release of growth hormone is correct. L-Arginine promotes the release of growth hormone by inhibiting the release of somatostatin in the brain.

According to a [International Journal of Endocrinology, 2022] systematic review and meta-analysis, “meta-analyses showed significant effects of ARG alone on GH release (MD = 10.07, 95% CI: 7.87, 12.28). Moreover, the response of GH was greater with ARG in combination with GHRH (MD = 24.96, 95% CI: 17.51, 32.42).” The research concluded that “in GH-deficient individuals, high doses of ARG supplementation in combination with GHRH and/or other amino acids might have potential therapeutic effects on increasing GH concentrations.”

✔️ L-Glutamine

Researchers from the American Institute of Clinical Nutrition found that even with the use of 2 grams of L-Glutamine, the amount of freely circulating growth hormone in the blood rises after an hour and a half. At night, L-Glutamine also increases the secretion of growth hormone.

According to a [Welbourne, American Journal of Clinical Nutrition, 1995] clinical study, “a surprisingly small oral glutamine load is capable of elevating alkaline reserves as well as plasma growth hormone.” The study found that ninety minutes after the glutamine administration (just 2 grams dissolved in a cola drink), both plasma bicarbonate concentration and circulating plasma growth hormone concentration were significantly elevated in 8 of 9 healthy subjects.

✔️ Colostrum

Colostrum consists of many growth factors that are nearly identical to those found in humans.

According to [Journal of Functional Foods, 2024] comprehensive review on bovine colostrum, “Bovine colostrum is a special supplement source due to its natural, high bioavailability and high concentrations of growth factors. Growth factors including IGF-1, IGF-2, TGF-β, and EGF are critical to many physiological functions.” The research confirmed that bovine colostrum contains insulin-like growth factors that are structurally similar to human IGF-1, supporting its potential role in growth and development.

✔️ Chromium

A lack of chromium leads to growth delays, causes neuropathy, and disorders of higher nervous activity.

According to [Zha et al., Journal of Zhejiang University Science, 2007] research, chromium supplementation “significantly increased lean body mass (P<0.05) due to the addition of 300 and 450 ppb Cr” and “supplementation of 150, 300, 450, and 600 ppb Cr decreased (P<0.05) percent body fat significantly.” The study concluded that “supplemental Cr has beneficial effects on growth performance and body composition,” suggesting chromium’s role in optimizing metabolic function and supporting healthy growth.

Since Growth Factor Plus includes many ingredients, it’s apparent that one might be concerned about its safety. Let us assure you that the supplement is manufactured in an FDA-approved facility that strictly adheres to good manufacturing practices, and all ingredients are certified as suitable for human consumption by a third-party laboratory for your peace of mind.

How to take Growth Factor Plus

Moving on to the next part of our review, let us guide you on how to take this supplement to maximize its benefits. It’s super-simple and easy to remember.

You need to take one pill before going to sleep at night. This is because your HGH level increases significantly during sleep at night, and Growth Factor Plus enhances the process, allowing your physical system to make the necessary changes to support your body’s growth.

According to [Levshtein et al., Frontiers in Endocrinology, 2025], “Evening GH injection better imitates the physiological diurnal pattern of GH secretion and is supposed to improve sleep in growth hormone deficiency (GHD).” This research supports the timing recommendation for taking HGH-supporting supplements at night to align with the body’s natural growth hormone secretion patterns during sleep.

It mainly builds the spinal column for adults and other essential parts of the body for minors. Growth Factor Plus works in a way that reduces the need for heavy workouts, although it’s recommended for those who can for even more efficient outcomes.

Proven benefits

It’s a scientifically proven fact that during the age of 15 to 19, your growth hormones work more efficiently and you grow at a faster pace. Taking Growth Factor Plus daily during that age period could increase HGH production in your body, which eventually helps you grow faster and get taller compared to someone who isn’t taking this product.

Increased HGH production further supports a better sleep cycle, helps prevent obesity, and regulates blood sugar levels. The collagen content of Growth Factor Plus works as a potent anti-aging agent, maintaining your skin, hair, and dental health.

According to [Fernández-Garza, Growth Hormone & IGF Research, 2025], growth hormone plays multiple roles beyond linear growth: “This review examines the molecular mechanisms of GH in aging, its potential as an anti-aging therapy, and findings from clinical trials.” The research confirms that GH affects metabolism, body composition, muscle mass, and bone density throughout life, supporting the multi-functional benefits associated with maintaining healthy HGH levels.

Any further benefit apart from the increased HGH level?

You bet! The micronutrients inside Growth Factor Plus strengthen your immunity, neurophysiological mechanisms, and the whole endocrine system for your overall well-being.

Wrapping up our review: Growth Factor Plus never went through any clinical trial, and that’s not necessary at all, as this is not a drug that promises to cure specific ailments, but a supplement that compensates for the lack of crucial nutrients (which are responsible for your body’s growth) you are supposed to get from your daily diet.

References

1. Zhao, Q., et al. (2025) “Recombinant growth hormone improves growth and adult height” — https://pmc.ncbi.nlm.nih.gov/articles/PMC11983003/ Published in Translational Pediatrics. Demonstrates that rhGH treatment effectively improves final height SDS and height SDS gain in children with idiopathic growth hormone deficiency (IGHD), with patients receiving treatment achieving significantly greater adult height (P=0.003).
2. Kim, G. & Yu, J. (2025) “Clinical and genetic investigation in children with short stature” — https://academic.oup.com/jes/article/doi/10.1210/jendso/bvaf149.1766/8298271 Published in Journal of the Endocrine Society. Clinical investigation of 59 children with short stature using growth hormone stimulation tests with pharmacologic stimulants including arginine, confirming diagnostic protocols for GHD identification.
3. Hindawi International Journal of Endocrinology (2022) “Growth Hormone Response to L-Arginine Alone and Combined with Different Doses of Growth Hormone-Releasing Hormone: A Systematic Review and Meta-Analysis” — https://www.hindawi.com/journals/ije/2022/8739289/ Systematic review confirming significant effects of arginine alone on GH release (MD = 10.07, 95% CI: 7.87, 12.28) and greater response when combined with GHRH (MD = 24.96, 95% CI: 17.51, 32.42).
4. Sanmedica International Clinical Trial (2020) “Increased human growth hormone following oral amino acid supplementation” — https://pmc.ncbi.nlm.nih.gov/articles/PMC6732240/ Double-blind, randomized, placebo-controlled study showing amino acid supplement containing L-lysine, L-arginine, L-glutamine increased hGH levels by 682% (8-fold) from baseline (p=0.01).
5. Welbourne, T.C. (1995) “Increased plasma bicarbonate and growth hormone after oral glutamine load” — https://pubmed.ncbi.nlm.nih.gov/7733028/ Published in American Journal of Clinical Nutrition. Clinical study demonstrating that 2 grams of oral glutamine significantly elevated plasma growth hormone concentration 90 minutes after administration.
6. Journal of Functional Foods (2024) “Revealing the Potency of Growth Factors in Bovine Colostrum” — https://pmc.ncbi.nlm.nih.gov/articles/PMC11279796/ Comprehensive review confirming bovine colostrum contains high concentrations of growth factors (IGF-1, IGF-2, TGF-β, EGF) critical for physiological functions and growth support.
7. Zha, L., et al. (2007) “Effects of chromium nanoparticle dosage on growth, body composition, serum hormones” — https://pmc.ncbi.nlm.nih.gov/articles/PMC1859878/ Published in Journal of Zhejiang University Science. Research demonstrating chromium supplementation significantly increased lean body mass (P<0.05) and decreased body fat percentage, supporting metabolic optimization for growth.
8. Levshtein, A., et al. (2025) “Morning vs. evening growth hormone injections and their impact” — https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1483199/full Published in Frontiers in Endocrinology. Research confirming evening GH administration better mimics physiological diurnal secretion patterns and improves sleep quality.
9. Fernández-Garza, L.E. (2025) “Growth hormone and aging: a clinical review” — https://pmc.ncbi.nlm.nih.gov/articles/PMC12009952/ Published in Growth Hormone & IGF Research. Comprehensive review examining GH’s molecular mechanisms in aging, metabolism, body composition, and anti-aging therapeutic potential.
10. Medical News Today (2025) “Is there any way to get taller as an adult?” — https://www.medicalnewstoday.com/articles/319504 Medical reference confirming that once growth plates close after puberty, supplements cannot increase height, but can support bone health and posture through calcium and vitamin D supplementation.

Research Team

The BoostHormone Research Team is a collective of fitness researchers, nutrition specialists, and health science professionals dedicated to providing evidence-based information about hormone optimization and performance enhancement.

With expertise in sports nutrition, endocrinology, and supplement science, our team analyzes peer-reviewed research and clinical studies to deliver honest, science-backed insights. We cut through industry hype to provide the accurate information you need to make informed decisions about your health and performance.

Our mission: translate complex scientific research into practical, actionable guidance – always prioritizing your safety and long-term wellness. Read Our Editorial Guidelines.

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