S4 Andarine SARM Review – Results, Stacks, Cycles, Side Effects

Andarine or S4 is one of the most common and popular products in the SARMs category (selective androgenic receptor modulators). It was originally developed to treat muscle atrophy and several other diseases. To the end of our complete S4 Andarine review you will know:

  • how to take the SARM on cycle
  • how to stack it correctly
  • all the main benefits
  • which results you can get
  • comparison to the other SARMs

What is Andarine?

S4 is one of the most powerful compounds. Moreover, it begins to work very quickly, thanks to which bodybuilders can count on impressive results in the shortest possible time. Due to its high efficiency, S4 is popular in all powersports, especially in bodybuilding.

However, no one reports that Andarine is no longer under study. Even though according to the statements from many sources the drug was very promising and showed incredible results, officially all the studies have been stopped.

S-4 is known to be friendly with the receptors of muscle and bone tissue.  So, it does not affect their work. Unlike other SARMs, it does not violate metabolism, does not lead to an increase in cholesterol levels, does not do any harm to the heart, and does not even force the appearance of swelling.

Initially, the SARM was developed as a drug that fights muscle atrophy. 1  It was actively used in treating osteoporosis, prostate hyperplasia, muscle mass loss, provoked by serious diseases (AIDS, oncology). 2

Which results you can get on the Andarine cycle?

Andarine results

When it comes to lean muscle gain, SARMs have the highest effect. Andarine has undergone clinical trials in humans, although the results have not been published. According to insider information, S4 has been described as “ideal SARM” thanks to:

  • Complete oral bioavailability
  • Using once a day
  • Anabolic effect on muscle and bone tissue 3

It should be noted that Andarine is a partial antagonist. Because of this, it is often referred to as a weaker SARMs, although in reality, it is not so.

A huge advantage of Andarine is its efficiency even at low dosages. Due to its rapid action and high bioavailability, you will be able to notice the first serious results within a few weeks. Due to the high anabolic effect, you can expect steroid-like action from S4. The main effect of the drug will be the boosting of muscle strength and mass, as well as strengthening the bones.

Andarine is guaranteed to accelerate muscle mass growth. Moreover, it does not lead to the retention of excess fluid in the body or swelling, like some other bodybuilding drugs. One of the essential effects of this SARM is impressive strength enhancement. After 2 weeks, you will notice that the working weight began to grow steadily at an accelerated rate.

Andarine before and after photos

Andarine before and afterBefore after photo Andarine

Examples of Andarine cycles and stacks

Andarine is often stacked with LGD-4033, RAD-140, SR-9009, YK-11, MK-677 for more pronounced muscle growth and enhanced functioning. Such stacks allow us to gain impressive amounts of lean muscles in a short period, as well as to get more muscle definition.

Andarine and Ligandrol stack

If you work out with a calorie deficit and want to not only improve muscle definition but also to keep muscle mass, the S4 with MK-677 is the best combination. If you are an experienced athlete, you can also stack with YK-11, or LGD-4033, or RAD-140.

Andarine is also combined with other drug categories. Many positive reports are published from the stack on the Andarine and Trenbolone cycle. Even with the use of low doses, the stack has had a huge impact on increasing muscle mass.

However, it should be noted that at the moment there is no complete information on how to combine SARMs and other drugs, so their stacking should be treated with caution.

Andarine vs Ostarine

Andarine vs Ostarine

These two SARMs are often compared to each other because of a similar effect. It is impossible to say for sure which drug will be better in individual situations. It is believed that Ostarine is more effective on cutting and in recomp cycles, where you need to simultaneously build muscle and burn fat.

It is also effective for recovery after injuries. However, its anabolic effect is not as powerful as that of Andarine. That’s why S4 is mainly used for better muscle growth and strength boost. In general, both of the SARMs are incredibly popular, but in some countries, Ostarine is banned in sports.

Workout supplements to use together with S4

Ideally, the SARMS must be stacked with a proper nutrition plan and taking of sports supplements. It is sports nutrition that will allow you to make up for the nutritional deficiencies that you will have on the SARMs cycle.

SARMs allow your body to work at all 200%, which means that you need even more nutrients than you have previously received.

What can we recommend you to take on a SARMs cycle?

  1. Amino acids and BCAA
  2. Protein
  3. Vitamins and minerals
  4. Fatty acids

These supplements are necessary to maintain muscle growth, rapid recovery, good health, proper immune system, and overall health.

To get even more benefits from workouts, we recommend you to take pre-training complexes. These supplements will allow you to develop not only physical but also mental endurance and motivation.

For men with lower test levels, testosterone boosters will be a great help also. Testosterone supplements will be increasing the natural production of this hormone, which gives you all the positive testosterone effects: higher libido, increased strength, rapid muscle growth, and aggression in the gym.

Is Andarine legal and safe or illegal?

It is noteworthy that Andarine is legal. It’s a “magical drug” that can be taken without any fear.

What are the main benefits?

Andarine for fat loss and weight loss

Andarine for fat loss

Andarine destroys fat very well. So you can take it during active slimming and on cutting cycles. 4

Fat burning properties of S-4 are similar to that of steroids Anavar and Winstrol.

As a result of Andarine intake, the growth of the fat layer stops. The level of lipoprotein lipase, an enzyme that causes the accumulation of lipids, drops dramatically. As a result, the weight also drops rather quickly.

Even if you stick to a strict diet, your muscle mass will not decrease. If you work out, on the contrary, it will increase.

Do not forget about the pump. S-4 makes muscles poured with blood, releases veins – a picture resembles of Schwarzenegger movies. It does not harm the heart. Perfect bodybuilder’s assistant! Which, unfortunately, cannot be said about most steroids.

Here’s how to use S4 for cutting

If you want to melt the fat and get it out of your body, take 50 mg of Andarine per day for 4 to 6 weeks. This dosage is optimal for most users.

However, it is not very modest and sometimes poorly tolerated by some athletes. To avoid unwanted reactions, use the scheme “take 5 days, then 2 days rest”. It has proven to be effective and as safe as possible.

Double effect. How to take for recomposition (increase in muscle mass plus fat loss)

Since most people not only want to lose weight but also to build lean muscle. The dosage here will remain the same (about 50 mg per day or a little more), but the system of training and nutrition will change.

If for weight loss you should pay more attention to cardio and eat fewer carbohydrates, then for muscle growth you should pray for proteins and focus on strength. Then, the result is sure to be – you’ll be losing weight and increase your muscles simultaneously.

Is Andarine good for bodybuilding?

SARMs such as Andarine have great potential for use in bodybuilding, fitness, athletics… – everywhere where the look, strength, endurance, and muscles determine success.

Andarine not only protects the muscles from destruction but also stimulates their active growth! This is the beauty of it. By using it, you can easily maintain good physical shape and improve it quite easily.

Use Andarine, if you want:

Andarine for bodybuilding

  • the muscles that everyone dreams about
  • consistently high testosterone levels
  • great strength
  • pronounced lipolytic effect
  • strong ligaments and joints

As you already know, S-4 can be stacked with other SARMS. The main thing here is to keep in mind the dosages and not to live according to the principle of “the more, the better”.

Andarine for recomp

Here is how to use S4 for increasing muscle mass and losing fat simultaneously.

When you take S-4 in doses of 50-75 mg per day for 4 to 8 weeks, the pronounced double effect will be provided. It is great if during the cycle you slightly increase the usual caloric value of your diet by increasing proteins. At least 30% of the food you eat should be made up of proteins. So, long live chicken breasts and cottage cheese.

If the Andarine action does not seem strong enough, you can try stacking it with other anabolic SARMs. For example, a good friend of S-4 is Ostarine.

Andarine vs Ligandrol

Andarine vs Ligandrol

If you don’t want to set the alarm clock so that you don’t forget to drink another dose of S4 (because ideally, you should do it every 4 hours), pay attention to its analog – Ligandrol.

LGD-4033 was also created for the treatment of muscle atrophy. 5  It has a half-life of 24-36 hours. Therefore, it is much more convenient to use it – capsules have to be swallowed only once a day.

Lets compare these two SARMs:

Comparison CriterionAndarineLigandrol
Daily dose: for women  50 mg    -men: 50-75 mgwomen:    0.5 to 10 mg

men: from 2.5 to 20 mg

Half-life period:4 hours24-36 hours
Side effects:temporary deterioration of visionpotency reduction, not stable BP, acne
Fat burning:activemediocre
Muscle growth:slowactive
The PCT:not neededis needed

In general, Ligandrol surpasses Andarine in terms of muscle mass building and is more convenient to take it. But it causes more side effects, and therefore is a more serious drug.

Andarine S4 dosage

The S4 is almost perfect at low and medium dosages. Since Andarine has high anabolic activity, it is recommended not to experiment with high dosages. For most athletes, the range will be between 25 and 75 mg per day.

To achieve a more noticeable effect, it is recommended that the daily dosage be divided into several sessions during the day. The exact half-life is unknown, but according to reports, it is approximately 4-6 hours. Based on these data, the daily dosage should be divided into 2-3 doses.

The optimal dosage is 50 mg. According to most studies and practical observations, the range from 25 to 50 mg provides the best outcomes.

Does S4 have any side effects?

When taking S4, you don’t have to worry about classical “side effects” such as acne, gynecomastia, fluid retention, hair loss, and others. However, this does not mean that S4 does not have any side effects at all.

Andarine cycle can depress the natural production of some hormones, such as testosterone. To return the testosterone level to its normal values after the S4 cycle, it is recommended to take a PCT. Also, note that the drug has not been fully tested for long-term side effects.

Although the manufacturers assure you that Andarine does not have any dangerous side effects, we thought it was necessary to warn you that some users complain about vision impairment while taking it.

The problem only manifests itself on the cycle and disappears without a trace after its completion. Scientists have found that the blurred picture is due to the metabolite M1, which is formed by S4 breakdown. As soon as it leaves the body, the visual function is fully restored.

A little hack! To protect your eyes, follow the scheme “5 – 2”. That is, take the SARM for 5 days followed by 2 days break.

Where to buy Andarine chaper?

You can order S4 online from couple trusted brands! Here is our short list of the best SARM companies (you will find discount coupons from each vendor). So, check the list of the trusted brands to buy Andarine and other SARMs online.

References:


  1. Amanda Jones, Dong-Jin Hwang, Ramesh Narayanan, Duane D Miller, James T Dalton – “Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy” – https://pubmed.ncbi.nlm.nih.gov/20534726/
    Endocrinology. 2010 Aug;151(8):3706-19. doi: 10.1210/en.2010-0150. Epub 2010 Jun 9.

  2. Jiyun Chen, Juhyun Kim, and James T. Dalton – “Discovery AND Therapeutic Promise OF Selective Androgen Receptor Modulators” –  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072877/
    Mol Interv. Author manuscript; available in PMC 2007 Nov 9. Published in final edited form as: Mol Interv. 2005 Jun; 5(3): 173–188. doi: 10.1124/mi.5.3.7

  3. Jiyun Chen, Juhyun Kim, and James T. Dalton – “Discovery AND Therapeutic Promise OF SARMs” –  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072877/
    Mol Interv. Author manuscript; available in PMC 2007 Nov 9. Published in final edited form as: Mol Interv. 2005 Jun; 5(3): 173–188. doi: 10.1124/mi.5.3.7

  4. Jeffrey D Kearbey, Wenqing Gao, Ramesh Narayanan, Scott J Fisher, Di Wu, Duane D Miller, James T Dalton – “Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats” – https://pubmed.ncbi.nlm.nih.gov/17063395/
    Pharm Res. 2007 Feb;24(2):328-35. doi: 10.1007/s11095-006-9152-9. Epub 2006 Oct 25.

  5. Shehzad Basaria, Lauren Collins, E. Lichar Dillon, Katie Orwoll, Thomas W. Storer, Renee Miciek, Jagadish Ulloor, Anqi Zhang, Richard Eder, Heather Zientek, Gilad Gordon, Syed Kazmi, Melinda Sheffield-Moore, and Shalender Bhasin – “The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men” – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111291/
    J Gerontol A Biol Sci Med Sci. 2013 Jan; 68(1): 87–95. Published online 2010 Mar 28. doi: 10.1093/gerona/gls078