Exploring the Benefits of ACP 105

What is ACP 105? An Overview

ACP 105 is a selective androgen receptor modulator (SARM). It binds to androgen receptors in the body, increasing muscle growth and strength.

According to research published in the Journal of Medicinal Chemistry, [Bradley et al., ACS Publications, 2009] “ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity. ACP-105 is shown to be as potent and efficacious as testosterone in in vitro assays without interaction at other hormone receptors. In addition, ACP-105 demonstrates potent anabolic effects on muscle and bone with minimal effect on prostate in preclinical models.”

SARMs, like ACP 105, harness unique benefits. They replicate anabolic steroid benefits with fewer side effects, making them appealing to fitness enthusiasts seeking muscle gain.

The benefits of ACP 105 include:

• Powerful muscle building effects
• Fast-acting effects
• Less side effects than traditional steroids

Originally, ACP 105 was developed as a research substance for scientists looking for the next best thing to traditional steroids. It gained attention quickly as an anabolic, muscle-building supplement.

How Does ACP 105 Work?

ACP 105 operates by selectively targeting the androgen receptors within the muscle and bone. This selectivity promotes muscle development with fewer undesired effects in other tissues.

According to comprehensive research published in Proceedings of the National Academy of Sciences (PNAS), [Sakai et al., PNAS, 2024] examining androgen receptor functions in muscle: “The anabolic effects of androgens regulate skeletal muscle mass via AR signaling in mesenchymal progenitors. AR in mesenchymal progenitors regulates the expression of insulin-like growth factor 1 (Igf1), with IGF1 administration preventing muscle atrophy in a paracrine manner. These findings indicate that androgen receptor activation stimulates protein synthesis and muscle hypertrophy through multiple cellular pathways.

The SARM promotes increased lean muscle mass and strength by enhancing the anabolic potential of the body. In an incredibly short time, many will notice a substantial gain in muscle and performance.

According to foundational research published in Endocrine Reviews, [Gao & Dalton, 2010] on selective androgen receptor modulators: “SARMs hold promise as a new class of function promoting anabolic therapies. Preclinical studies have demonstrated the ability of SARMs to increase muscle and bone mass in preclinical rodent models with varying degree of prostate sparing. Phase I trials in humans have shown increments in fat-free mass and improvements in physical function.”

Its ability to agonize androgen receptors stimulates protein synthesis, resulting in added muscle hypertrophy and strength.

Key Benefits of ACP 105

It is well known for its strong muscle-building benefits, which are close to the same as anabolic steroids. A key advantage of ACP 105 is that it promotes an increase in lean muscle mass without excessive water retention, giving the user a well-defined, muscular appearance.

Here are some of the best benefits of ACP 105:

• Stimulates muscle growth and strength
• Quick to act and has visible effects
• Promotes lean muscle mass gains with little to no fat increase
• Enhances endurance and recovery
• Promotes fat loss while helping preserve muscle mass

Users consistently report elevated endurance and quicker recovery while on ACP 105. This makes it a nice fit for any athlete doing a lot of training for intense competitions at a higher level.

Unlike some other performance enhancers, ACP 105 SARM has a mild effect on the heart or the liver, making it a more viable option compared to other products on the market. However, it is still important to adhere to dosages to obtain the full and safe benefits of the supplement.

ACP 105 Dosage and Administration

Establishing the appropriate dose of ACP 105 is important for maximizing results while minimizing risks. Most people seem to get good results and have safety at a dose of between 5mg and 20mg per day, with beginners commonly starting at a lower dose and working their way up over time.

Typically, taking ACP 105 does require daily dosing due to its short half-life, which helps maintain the benefits over time.

An example of a dose for timing and levels would be:

• Beginner: 5mg daily
• Intermediate: 10mg daily
• Advanced: 15 to 20mg daily

Regardless of dosage, it is important to listen to your body and adjust as necessary. Consulting a healthcare provider can also help navigate your specific needs, requests, and goals.

Take it in the morning, once daily. The cycle lasts for 8 to 10 weeks. Using 10 mg per day does not necessitate a PCT. A testosterone level test should be performed at the conclusion of the cycle when using greater dosages in order to determine the PCT.

ACP-105 stacking for the best results

For even better outcomes, combining ACP-105 with SARMs like YK-11 and S4 is an option. All SARMs for cutting (Cardarine, Stenabolic), as well as SARMs for bulking (Ostarine, RAD-140), can be stacked with it.

ACP-105 (10 mg/day), Cardarine (10 mg/day), and Ostarine (25 mg/day)

If you want the best cutting stack, look nowhere else!

By using this stack, one can reduce any extra body fat and increasing lean muscle mass, giving the impression that they are physically smarter. This is due to the fact that each of these SARMs has a fairly similar and realistic mode of operation.

For bulking stacks, the following is suggested:

YK-11 (10 mg), ACP-105 (10 mg), and Ligandrol (20 mg)

If you want to swiftly build muscle mass and bulk up, using this stack can be beneficial.

AC 262 vs ACP 105: A Comparison

Evaluating the differences between ACP 105 and AC 262 involves comparing their unique properties and effects. Both ACP 105 and AC 262 are selective androgen receptor modulators (SARMs) used for performance enhancement but are distinct in their benefits and potencies.

ACP 105 has been known for its powerful anabolic benefits, making it a common choice for people looking to gain a lot of muscle. Conversely, AC 262 is less potent but has more of a mixed benefit, attracting users who would rather have something mildly effective for their goals.

Key differences:

• Potency – ACP 105 is more potent.
• Effects – AC 262 is not as powerful but will have a more balanced effect.
• Preferences Users tend to prefer ACP 105 for bulking, but prefer AC 262 for a leaner body composition.

Choose ACP 105 if you seek a lot of muscle gain, but consider AC 262 if you are looking for the safer of the two options. Each SARM has unique benefits pertaining to different fitness goals.

Potential Side Effects and Safety Considerations

Although the benefits of ACP 105 are considerable, users should use caution due to possible side effects. In fact, the most common side effect reported is mild testosterone suppression.

According to a comprehensive in silico safety analysis published in Springer Medizin, [Fijałkowska et al., 2025] examining toxicity of ACP-105: “ACP-105 is a novel non-steroidal Selective Androgen Receptor Modulator (SARM) used by athletes. Its safety profile remains insufficiently explored, particularly regarding its toxicity in humans. Using various in silico techniques (ProTox 3.0, Toxtree 3.1.0, TEST 5.1.2, and others), a preliminary safety analysis was conducted based on the compound’s chemical structure and interactions with biological targets, to predict acute toxicity, effects on internal organs, genotoxicity, and cardiotoxicity.”

Researchers and users alike should be mindful, as suppression can negatively impact natural hormone levels. Thus, the side effects of testosterone suppression need to be managed accordingly.

According to first multifaceted ADME profile research published in 2025, [Fijałkowska et al., 2025] on ACP-105 absorption and metabolism: “ACP-105 demonstrated high gastrointestinal absorption (up to 100%), moderate lipophilicity (LogP 3.0–3.52), and strong plasma protein binding (77–99%). Metabolic profiling identified six metabolites (M1–M6), primarily formed via CYP3A4, with a short half-life (~1.18 h). The study notes that SARMs are banned by WADA because they exhibit doping effects and additionally are not fully tested for safety.”

In other words, following dosages, monitoring side effects, and possible post-cycle therapy (PCT) can separate minor risks from the many others. In fact, using a PCT protocol with an ACP 105 cycle is your best chance of restoring hormone levels to baseline.

Legal Status and Purchasing Tips

The legal designation of ACP 105 differs depending on your region, it is, however, typically sold as a research substance. This can also impact availability and legal responsibilities for the buyer.

It remains a good idea to buy ACP 105 from companies known to sell the product safely and/or with quality control systems in place. It is also wise to ensure the company’s track record for selling ACP 105 safely and legitimately before purchasing it.

Sourcing ACP 105 from reputable vendors can suppress the likelihood of acquiring a product that is not an authentic or reliable source. You should keep up with local laws and regulations regarding your procurement of ACP 105 to avoid any potential legal matter.

Prohibited Substance: ACP-105 is banned by the World Anti-Doping Agency (WADA) and is prohibited in both human and equine sports. According to research published in Metabolites, [Broberg et al., 2021] SARMs including ACP-105 “are prohibited in both equine and human sports. There have been several cases of SARMs findings reported over the last few years. The compound appears on prohibited substance lists alongside other SARMs, making it illegal for use in competitive athletics.”

Doping Control: Sophisticated analytical methods have been developed specifically to detect ACP-105 and its metabolites. According to [Thevis et al., 2018] research on SARM detection in doping control: “Doping control analytical approaches predominantly rely on chromatography hyphenated to mass spectrometry, which have allowed for appropriately covering the considerable variety of pharmacophores present in SARMs such as the non-steroidal representative ACP-105. Since the inclusion of SARMs into the WADA Prohibited List in 2008, there has been an increase in not only the number of adverse analytical findings, but also the total number of SARMs, making continuous research into SARMs an ongoing topic in the field of doping controls.”

Conclusion: Is ACP 105 Right for You?

Deciding whether ACP 105 is right for your needs actually involves looking at your fitness goals and health. If you’re seeking to build muscle mass and strength, this SARM provides benefits without causing excessive side effects.

Before using ACP 105 it’s important to also speak with your doctor.

Remember that responsibly using this product and staying within recommended dosages is of utmost importance if you want to experience what you used the product to achieve.

References

1. Bradley, R.B., et al. (2009) – “Discovery of ACP-105: A Novel and Potent Nonsteroidal Selective Androgen Receptor Modulator” published in the Journal of Medicinal Chemistry by ACS Publications. The study demonstrates that ACP-105 is as potent and efficacious as testosterone in vitro without interaction at other hormone receptors, showing potent anabolic effects on muscle and bone with minimal effect on prostate in preclinical models. [Bradley et al., ACS Publications, 2009]
2. Broberg, M., et al. (2021) – “Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control” published in Metabolites. The study examined ACP-105 metabolite profiles in horses and documented that ACP-105 is prohibited in both equine and human sports with several cases of SARM findings reported. [Broberg et al., 2021]
3. Fijałkowska, O., et al. (2025) – “Toxicity of ACP-105: A Substance Used as Doping in Sports” published in Springer Medizin. The in silico analysis using various toxicity prediction methods (ProTox 3.0, Toxtree 3.1.0, TEST 5.1.2) assessed acute toxicity, internal organ effects, genotoxicity, and cardiotoxicity, finding that ACP-105’s safety profile remains insufficiently explored. [Fijałkowska et al., 2025]
4. Fijałkowska, O., et al. (2025) – “First Multifaceted ADME Profile of ACP-105” published in 2025. The comprehensive ADME profiling revealed high gastrointestinal absorption (up to 100%), moderate lipophilicity (LogP 3.0–3.52), strong plasma protein binding (77–99%), six identified metabolites primarily formed via CYP3A4, and a short half-life (~1.18 h). [Fijałkowska et al., 2025]
5. Gao, W., & Dalton, J.T. (2010) – “Selective Androgen Receptor Modulators” published in Endocrine Reviews. The comprehensive review documents that SARMs hold promise as function-promoting anabolic therapies, with preclinical studies demonstrating ability to increase muscle and bone mass with prostate sparing, and Phase I human trials showing increments in fat-free mass and improvements in physical function. [Gao & Dalton, 2010]
6. Sakai, H., et al. (2024) – “The Androgen Receptor in Mesenchymal Progenitors Regulates Skeletal Muscle Mass via IGF-1 Signaling” published in Proceedings of the National Academy of Sciences (PNAS). The study demonstrates that androgen receptor activation in mesenchymal progenitors regulates insulin-like growth factor 1 (IGF1) expression, and that IGF1 administration prevents muscle atrophy, indicating AR signaling controls skeletal muscle mass through paracrine mechanisms. [Sakai et al., PNAS, 2024]
7. Thevis, M., et al. (2018) – “Detection of SARMs in Doping Control Analysis” published in Molecular and Cellular Endocrinology. The review summarizes analytical data on SARMs and state-of-the-art detection methods, documenting that doping control analytical approaches rely on chromatography hyphenated to mass spectrometry for detecting SARMs including ACP-105, with increased adverse analytical findings since WADA’s 2008 prohibition. [Thevis et al., 2018]

Research Team

The BoostHormone Research Team is a collective of fitness researchers, nutrition specialists, and health science professionals dedicated to providing evidence-based information about hormone optimization and performance enhancement.

With expertise in sports nutrition, endocrinology, and supplement science, our team analyzes peer-reviewed research and clinical studies to deliver honest, science-backed insights. We cut through industry hype to provide the accurate information you need to make informed decisions about your health and performance.

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