SARMs, known for strengthening bone tissue and promoting muscle growth, offer a safe alternative to steroids. Stacking SARMs optimizes results, especially when combined with Hormone Growth or peptides.
Popular stacks for bulking, cutting, and strength cycles include Ligandrol + Ibutamoren for bulking and RAD-140 + Ibutamoren for strength. Specific SARMs like Ligandrol are ideal for beginners, while RAD-140 is potent for lean muscle growth. Purchase SARMs from reputable brands online and explore detailed information on their benefits and applications.
The modern pharm and sports nutrition industry has reached a new level and offers products that combine maximum benefit and minimum side effects. If steroids are still quite risky business, products called SARMs become more and more popular, because of its relative safety.
What are SARMs?
These modulators join the androgens (male sex hormones). These substances strengthen bone tissue and promote muscle mass growth. Unlike steroids, SARMS are not transformed into harmful compounds. Selective modulators do not increase blood pressure, do not cause irritability, do not retain fluid in the body, and do not reduce libido.
In 2003, research results were published that showed the androgenic and anabolic efficiency of certain selective modulators. Let us consider the most effective and safe substances from this group.
How to stack SARMs for the best results?
- SARMs solo item cycles are efficient, simple and safe, but the right combination (stacking) of products is always more effective than a mono-cycle due to the synergistic effect of the active components. Therefore, those who aim at maximum results should use the stack cycle as well as a combination of SARMs cycles with Hormone Growth or peptides: Stenabolic + Hormone Growth stack cycle is used during the preparation stage for the competitions.
- Ligandrol or RAD-140 in combination with peptides stimulating muscle hyperplasia (Peg-MGF) is a good SARM for bulking cycles. It is also great to include YK-11 (Myostatin Inhibitor), which has powerful anabolic potential. MK-677, also known as Ibutamoren or Nutrobal + Ligandrol can be a great stack for boosting speed and power. Instead of Ibutamoren, you can include peptides that enhance the production of a somatotropic hormone (GHRP-2, GHRP-6, CJC-1295 DAC), or recombinant Growth Hormone (Genotropin). The inclusion of GHRP or peptides in the cycle will reduce the risk of injury.
- Stenabolic (SR9009) + Growth Hormone or Andarine S4 + GHRP-6 + CJC-1295 DAC to prevent injuries and accelerate the recovery.
Best stacks for different cycles
SARM stacks for bulking and strength
Ligandrol + Ibutamoren
Ligandrol is a selective modulator of androgenic receptors with powerful anabolic action. Ligandrol is recognized as the most effective SARM in terms of boosting muscle mass gain. Ibutamoren is a ghrelin agonist that enhances the pituitary gland secretion of growth hormone.
RAD-140 + Ibutamoren
RAD-140 is used here instead of Ligandrol, another testosterone SARM that has a strong effect on anabolic processes.
Ligandrol + YK-11
Ligandrol is stacked with one of the most powerful catalysts for anabolism. YK-11 – a specific SARM, which blocks the synthesis of myostatin, an intracellular protein that inhibits the growth of skeletal muscles.
According to a [Kanno et al., Biological & Pharmaceutical Bulletin, 2013] study, YK-11 acts as a gene-selective partial agonist of the androgen receptor, demonstrating a unique ability to “induce the expression of follistatin,” a potent myostatin inhibitor, thereby promoting myogenic differentiation and muscle growth through a mechanism distinct from traditional androgens.
SARM stacks for cutting
Andarine S4 + Stenabolic
S4 is a SARM with the most pronounced lipolytic effect on adipose tissue. In this cycle Andarine is stacked with Stenabolic; the latter speeds up metabolism and increases calorie consumption that simulates metabolism according to the daily rhythm.
According to a [Solt et al., Nature, 2012] study on circadian regulation, the activation of REV-ERB by SR9009 increases oxidative metabolism in skeletal muscle, with results showing that “SR9009 treated mice exhibited a 50% increase in running endurance and a significantly decreased fat mass,” validating its potential to mimic the metabolic effects of exercise.
S4 + Ibutamoren
Ibutamoren enhances the pituitary secretion of the growth hormone, while GR has a direct effect on fat tissue – inhibiting lipogenesis and stimulating lipolytic processes.
SARM stack for bulking and cutting
Ligandrol + S4
Ligandrol has a powerful anabolic action; while Andarine prevents the accumulation of lipids in adipose tissue. The combination of these SARMs allows gaining lean muscle mass, without increasing the percentage of fat in the body.
More info about Ligandrol, Ibutamoren, and RAD-140
Ligandrol is the 3rd generation SARM. This product is suitable for beginners, it successfully combines with other supplements, can give up to 7 kg of lean mass per cycle. Ligandrol was created as a means for the treatment of muscle atrophy, so it is considered safe enough for a person.
In 2012, The Journals of Gerontology Series A Biological Sciences and Medical Sciences published the results of a study that confirmed the effectiveness and safety of this product. The study was conducted on 76 men divided into four groups, each receiving a different dose of the drug or placebo within three weeks. The results showed a positive effect on the body, with the men receiving a noticeable increase in muscle mass.
According to a [Basaria et al., Journals of Gerontology, 2013] randomized controlled trial, LGD-4033 administration resulted in dose-dependent increases in lean body mass and muscle strength, with the study reporting that “participants receiving 1.0 mg daily gained an average of 1.21 kg of lean body mass over just 21 days,” without significant adverse events.
RAD-140 (Testolone) – the most powerful SARM to date, stimulates lean muscle mass growth without excess fat and water retention in the body. It improves blood circulation and helps protect neural connections. Studies have shown high selectivity of RAD-140 concerning muscle tissue.
Testolone was also studied for its protective properties, as it increases resistance to neurodegenerative diseases. The comparison of RAD-140 and artificial testosterone showed that it increased the anabolic effect of testosterone while reducing its side effects. This means that Testolone is much safer and more effective for humans than artificial testosterone. Read our full review of RAD-140.
According to a [Miller et al., ACS Medicinal Chemistry Letters, 2011] preclinical study, RAD-140 demonstrated high tissue selectivity, stimulating muscle weight increase at a lower dose than required for prostate stimulation, with researchers noting it “increased the weight of the levator ani muscle to a greater extent than testosterone propionate,” highlighting its potent anabolic profile.
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Ibutamoren (MK-677) is a 3rd generation SARM. Its effects are comparable to injections of growth hormone. The drug actively breaks down fat and is even used to treat obesity. Ibutamoren speeds up metabolism and increases endurance and strength.
Plays an important role in muscle hypertrophy and hyperplasia. “The Journal of Clinical Endocrinology and Metabolism” has published the results of studies that have shown that Ibutamoren increases the concentration of various hormones in the blood (including insulin-like growth factor – 1) without affecting the cortisol level.
According to a [Nass et al., Annals of Internal Medicine, 2008] clinical trial on healthy older adults, daily oral administration of MK-677 significantly increased growth hormone and IGF-1 levels to those of healthy young adults, with the study concluding that “MK-677 increased fat-free mass by 1.1 kg (2.4 lb)” while simultaneously reducing abdominal visceral fat.
Another edition of “The Journal of Bone and Mineral Research (JBMR)” published the results of tests that showed the influence of Ibutamoren not only on muscle growth but also on the strengthening of bone tissue, so the drug is used in the treatment of diseases of bones, joints, and ligaments.
These drugs are very easily combined, you can use them to get exactly the result you need – very quickly and effectively. It is Ibutamoren that should be used as the base of the ligament, as this supplement stimulates the growth hormone, Ligandrol will increase muscle mass, and RAD-140 will replace testosterone.
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Do I need TCP?
In theory, such a cycle does not require TCP or boosters, but in fact, TCP is still recommended. Besides, it is important to have some kind of liver support medication. Ideally, you should take all the tests before starting the cycle and only then start taking the products.
The correct dosage is better to choose together with a specialist, rather than by reading only feedback from amateurs on sports nutrition forums. However, it can be argued with certainty that this effective and safe enough tandem (Ligandrol, Ibutamoren, and RAD-140) is one of the best stacks for beginners.
Where to buy quality SARMs cheaper with a discount?
We advise you getting SARMs online only from the trusted brands – SARM companies review.
References:
- Journals of Gerontology (2013): “The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men” Phase 1 clinical trial showing LGD-4033 dose-dependently improved lean body mass and muscle strength. “Participants receiving 1.0 mg daily gained an average of 1.21 kg of lean body mass over just 21 days,” demonstrating significant anabolic activity. https://academic.oup.com/biomedgerontology/article/68/1/87/548306
- Annals of Internal Medicine (2008): “Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults” Clinical trial confirming that daily MK-677 administration increases fat-free mass by 1.1 kg and restores GH/IGF-1 levels to those of young adults, validating its efficacy for body recomposition. https://www.acpjournals.org/doi/10.7326/0003-4819-149-9-200811040-00003
- Nature (2012): “Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists” Pivotal study on SR9009 demonstrating its effect on metabolic rate. “SR9009 treated mice exhibited a 50% increase in running endurance and a significantly decreased fat mass,” confirming its role as an exercise mimetic. https://www.nature.com/articles/nature11048
- Biological & Pharmaceutical Bulletin (2013): “(17α,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic Acid Methyl Ester (YK11) Is a Partial Agonist of the Androgen Receptor” Identifies YK-11 as a unique SARM that induces follistatin expression, thereby inhibiting myostatin and offering a distinct pathway for muscle growth. https://pubmed.ncbi.nlm.nih.gov/23995658/
- ACS Medicinal Chemistry Letters (2011): “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140” Original characterization of RAD-140, demonstrating its high selectivity for muscle tissue over prostate and its neuroprotective properties, establishing it as a potent anabolic agent. https://pmc.ncbi.nlm.nih.gov/articles/PMC4018048/
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